Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery +25 more
wiley +1 more source
Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2024 for the Clinical Practice of Inflammatory Bowel Disease-Associated Intestinal Neoplasia (English Version). [PDF]
Ishihara S +39 more
europepmc +1 more source
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas +6 more
wiley +1 more source
Editorial: The gut microbiome's role in gastric cancer: mechanisms and therapies. [PDF]
Ağagündüz D, Giono-Cerezo S, Grant G.
europepmc +1 more source
Five Advances in the Last 50 Years That Have Impacted Endocrine Surgery
World Journal of Surgery, EarlyView.
Matilda Anneback +5 more
wiley +1 more source
BRD9 inhibition as potential treatment option for testicular germ cell tumors
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen +5 more
wiley +1 more source
Conjunctival Intraepithelial Neoplasia With IgG and Complement Deposition: Spurious Association or Biologically Explainable? [PDF]
Zhang DD, Raja D, Cheung WL, Margo CE.
europepmc +1 more source
Pancreatic Cancer—Advances in the Last 50 Years
World Journal of Surgery, EarlyView.
S. George Barreto +5 more
wiley +1 more source
Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?
ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto +12 more
wiley +1 more source

