Results 41 to 50 of about 20,569 (202)

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source

Carcinoma epidermoide de esófago, adenocarcinoma de colon y policitemia vera: tres neoplasias primitivas, un mismo paciente

Medicina General y de Familia, 2015
Resumen La aparicion de neoplasias primitivas multiples en un mismo paciente es un hecho que cada vez vemos con mas frecuencia. El envejecimiento de la poblacion, la posibilidad de acceso a los diferentes niveles de atencion sanitaria y la gran cantidad de medios diagnosticos (laboratorio, imagenologicos) con los que se cuenta en la actualidad son ...
Hermida Pérez, José Alberto, Capote León, Laura, Sobenes Gutiérrez, Rosa Janet, Pérez Concepción, Sonia Belén   +3 more
openaire   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Association between calcium intake and colorectal neoplasia in Puerto Rican Hispanics Asociación entre el consumo de calcio y la neoplasia colorectal en hispanos puertorriqueños

Archivos Latinoamericanos de Nutrición, 2010
Epidemiological studies show that a high calcium intake reduces the risk of colon cancer. The objective was to study the association between calcium intake and colorectal neoplasia in a clinic-based sample of Hispanics adults from Puerto Rico. As part of
Cristina Palacios, Maritza Lopez, Ana Patricia Ortiz, Marcia Cruz Correa   +3 more
doaj  

Riesgo de cáncer de colon en docentes universitarios de salud y humanidades, un estudio comparativo

CuidArte, 2020
Introducción: En México, el cáncer de colon ocupa el cuarto lugar de morbi-mortalidad con referencia a otros tipos de cáncer. Los factores de riesgo relacionados a la patología son: dieta hiperlipídica, sedentarismo, estrés, toxicomanías, enfermedades ...
Victoria Berenice Martínez Ramos, Sharon Vanessa Roa Escobar, Yamileth Martínez Montiel, Cinthya Carolina Solís Bernardo, Gladis Patricia Ariztizabal Hoyos, María Maricela Carrasco Yépez   +5 more
doaj   +1 more source

Broader Familial Cancer Risk in Relatives of Testicular Cancer Patients: Insights From Two Mediterranean Populations

Andrology, EarlyView.
ABSTRACT Background Familial clustering of testicular germ cell tumour (TGCT) is well‐established, whereas the risk of non‐testicular cancer among relatives remains inconsistent across studies. Objective To evaluate the overall and site‐specific cancer risk among first‐degree relatives and grandparents of TGCT patients compared to cancer‐free controls.
Csilla Krausz, Chiara Abrardo, Viktoria Rosta, Daniel Moreno‐Mendoza, Luca Bressan, Matteo Vannucci, Rebecca Passerotti, Arianna Meacci, Ginevra Farnetani, Viola Bonini, Giovanni Corona, Maria Grazia Fino, Eduard Ruiz‐Castañé, Antoni Riera‐Escamilla   +13 more
wiley   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Aspectos clínicos y epidemiológicos del cáncer colorrectal en Hospital General Docente “Vladimir Ilich Lenin” de Holguín

Correo Científico Médico, 2022
Introducción: El cáncer de colon ocupa el primer lugar dentro de las neoplasias del sistema digestivo y el segundo entre todos los procesos oncoproliferativos para ambos sexos.
Adrián Agüero Rodríguez, Edilio Silva Velasco, Dalila Chacon Bonet, Amalia Pupo Zúñiga, Adelmar Agüero Uliver   +4 more
doaj  

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source