Results 91 to 100 of about 851,717 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Other title: Administrative and Residual bargaining unit contract between State of Connecticut and Administrative & Residual Employees Union, Local 4200-AFT/AFTCT, AFL-CIO

, 2016
Title from cover.; "Effective: July 1, 2016, Expiring: June 30, 2021."; Includes ...
Connecticut,
core  

A stress free model for residual stress assessment using thermoelastic stress analysis [PDF]

, 2014
Thermoelastic Stress Analysis (TSA) has been proposed as a method of obtaining residual stresses. The results of a preliminary study demonstrated that when Al-2024 plate containing holes that were plastically deformed by cold expansion process to 2% and ...
Robinson, Andy, Howell, Geoff, Dulieu-Barton, Janice, Achintha, Mithila   +3 more
core   +1 more source

Residual stresses in bulk ceramics

, 2022
S.274-285Residual stresses in ceramics are of interest for two reasons. First, residual stresses are superimposed on external stresses and thus influence the service behavior of the machined parts.
Pfeiffer, W.
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evaluation of residual stress relaxation and its effect on fatigue strength of AISI 316L stainless steel ground surfaces: Experimental and numerical approaches [PDF]

, 2013
This paper is aimed at evaluating the residual stress relaxation and its effect on the fatigue strength of AISI 316L steel ground surfaces in comparison to electro-polished surfaces.
SIDHOM, Habib, LAAMOURI, Adnen, BRAHAM, Chedly   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

On Surface Grind Hardening Induced Residual Stresses [PDF]

, 2014
Grind hardening process utilizes the heat generated in the grinding area for the surface heat treatment of the workpiece. The workpiece surface is heated above the austenitizing temperature by using large values of depth of cut and low workpiece feed ...
Salonitis, Konstantinos
core   +1 more source

Integration of Next-Generation Sequencing in Measurable Residual Disease Monitoring in Acute Myeloid Leukemia and Myelodysplastic Neoplasm

Cancers
Background/Objectives. Recent evidence underscores the prognostic and classificatory relevance of somatic mutations in myelodysplastic neoplasms (MDSs) and acute myeloid leukemia (AML). Methods. This prospective study assessed gene mutation dynamics via next-generation sequencing (NGS) in 84 MDS/AML patients treated with intensive chemotherapy or ...
Elena Crisà, Irene Dogliotti, Giuseppe Lia, Marco Cerrano, Ernesta Audisio, Giuseppe Lanzarone, Lucia Brunello, Daniela Caravelli, Fabrizio Carnevale Schianca, Enrico Berrino, Sara Erika Bellomo, Alice Bartolini, Ludovica Riera, Paola Francia di Celle, Gianluca Gaidano, Monia Lunghi, Luisa Giaccone, Benedetto Bruno   +17 more
openaire   +2 more sources