Results 101 to 110 of about 851,717 (305)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Acinar Cell Cystadenocarcinoma of the Pancreas

Case Reports in Gastroenterology, 2017
Acinar cell cystadenocarcinoma is a rare malignant epithelial neoplasm of the pancreas with a diffusely cystic, gross architecture in which the cysts are lined with neoplastic epithelial cells that demonstrate evidence of pancreatic exocrine enzyme ...
Keita Aoto, Tatsuo Shimura, Yasuhide Kofunato, Ryo Okada, Rei Yashima, Yuichiro Kiko, Seiichi Takenoshita   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Determination of Residual Stress Distributions in Autofrettaged Thick Cylinders [PDF]

, 2008
High pressure vessels such as gun barrels are autofrettaged in order to increase their operating pressure and fatigue life. Autofrettage causes plastic expansion of the inner section of the cylinder – setting up residual compressive stresses at the ...
Gibson, Michael C.
core   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Glomus tumor of the hyoid bone: a case report and literature review

Frontiers in Oncology
Hyoid glomus tumors represent an exceptionally rare clinical entity. This study details a case presentation of a hyoid glomus tumor accompanied by a comprehensive systematic review, aiming to expand the clinical and pathological understanding of these ...
Mingrui Shi, Ming Han, Jiale Wang, Qi Zhao, Chenghao Ren, Huan Li, Zihui Yang, Jianhua Wei, Xinjie Yang   +8 more
doaj   +1 more source

Mioblastoma do pulmão

Revista Portuguesa de Pneumologia, 2000
RESUMO: O Mioblastoma de pulmão é um tumor raro, com origem nas células de Schwann, cujo modo de apresentação mais comum é a tosse e a toracalgia. Pode ser um achado radiológico ou endoscópico.O caso que apresentamos referese a um doente de sexo ...
J. Vizcaino, R. Sotio-Mayor, E. Teixeira, J. Maçanita, M.J. Palhano, A. Bugalho de Almeida   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Incidental diagnosis of intraductal papillary neoplasm of the bile duct: Imaging findings from a case report

Radiology Case Reports
Intraductal papillary neoplasms of the bile ducts (IPNBs) represent a rare biliary tract tumors with malignant potential, requiring surgical resection to prevent progression to cholangiocarcinoma.
Imene Chafai, MD, Alba Igual-Rouilleault, MD PhD, Morgane Van Wettere, MD   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source