Results 91 to 100 of about 98,057 (268)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

P120-catenin Isoforms 1A and 3A Differently Affect the Expression of E-cadherin and β-catenin in Lung Cancer Cells

Chinese Journal of Lung Cancer, 2009
Background and objective Different isoforms of p120-catenin (p120ctn), the members of catenin family, are variably expressed in different tissues and cells.
Enhua WANG, Yong ZHANG, Nan LIU, Changqing FANG, Yang LIU   +4 more
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The primary study on the application of gelatum invasive model as an invasiveness assay for glioma cells in vitro

Chinese Journal of Contemporary Neurology and Neurosurgery, 2010
Objective To investigate the feasibility of applying gelatum invasive model as an invasiveness assay for human glioma cells in vitro, observe the differences of invasiveness between adherently cultured differentiated human glioma cells and human glioma ...
Rui⁃fan XIE, Suo⁃jun ZHANG, Bao⁃cheng GAO, Feng WAN, Ting LEI   +4 more
doaj  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Two Synchronous Pseudoinvasive Adenomas: Twice the Caution?

GE: Portuguese Journal of Gastroenterology, 2016
Jaime Pereira Rodrigues, Rolando Pinho, Xiaogang Wen   +2 more
doaj   +1 more source

Solid Subtype of Papillary Thyroid Carcinoma: A Case Series Highlighting Aggressive Features

Clinical Case Reports
Papillary thyroid carcinoma (PTC) is the most common malignant thyroid neoplasm. Its solid/trabecular subtype (STPTC) is rare, and its aggressiveness remains controversial.
Rafael Castellanos Bueno, Gabriela Almeyda Carreño, Diana Carolina Vergara Arenas, Laura Yibeth Esteban Badillo, Ernesto García Ayala   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Primary Extradural Meningioma Presenting as Frontal Sinusitis with Extensive Bony Changes : Case report

Sultan Qaboos University Medical Journal, 2014
Primary extradural meningiomas are rare tumours and calvarial meningiomas with extensive bony changes and frontal sinusitis are rarer still. We report a 40-year-old female patient who presented to the otorhinolaryngologist at the Sultan Qaboos University
Rajeev Kariyattil, Venkatesh Govindaraju, Rana S. Hamid, Muthukuttiparambil Unnikrishnan   +3 more
doaj   +2 more sources