Results 11 to 20 of about 506,616 (289)

Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis

Clinics, 2018
The insulin receptor substrate (IRS) proteins are a family of cytoplasmic proteins that integrate and coordinate the transmission of signals from the extracellular to the intracellular environment via transmembrane receptors, thus regulating cell growth,
João Agostinho Machado-Neto, Bruna Alves Fenerich, Ana Paula Nunes Rodrigues Alves, Jaqueline Cristina Fernandes, Renata Scopim-Ribeiro, Juan Luiz Coelho-Silva, Fabiola Traina   +6 more
doaj   +3 more sources

Identification of Proteins and Genes Associated with Hedgehog Signaling Pathway Involved in Neoplasm Formation Using Text-Mining Approach

Big Data Mining and Analytics
Analysis of molecular mechanisms that lead to the development of various types of tumors is essential for biology and medicine, because it may help to find new therapeutic opportunities for cancer treatment and cure including personalized treatment ...
Nadezhda Yu. Biziukova, Sergey M. Ivanov, Olga A. Tarasova   +2 more
doaj   +2 more sources

Receptor-interacting protein in malignant digestive neoplasms [PDF]

Journal of Cancer, 2021
A deep and comprehensive understanding of factors that contribute to cancer initiation, progression, and evolution is of essential importance. Among them, the serine/threonine and tyrosine kinase-like kinases, also known as receptor interacting proteins (RIPs) or receptor interacting protein kinases (RIPKs), is emerging as important tumor-related ...
Zhang, Lilong, Guo, Wenyi, Yu, Jia, Li, Chunlei, Li, Man, Chai, Dongqi, Wang, Weixing, Deng, Wenhong   +7 more
openaire   +2 more sources

The Role of the Heat-Shock Proteins in Esophagogastric Cancer

Cells, 2022
Heat-shock proteins (HSPs) are a family of proteins that have received considerable attention over the last several years. They have been classified into six prominent families: high-molecular-mass HSP, 90, 70, 60, 40, and small heat shock proteins. HSPs
Francisco Tustumi, Gabriel Andrade Agareno, Ricardo Purchio Galletti, Rafael Benjamim Rosa da Silva, Julia Grams Quintas, Lucas de Abreu Sesconetto, Daniel José Szor, Nelson Wolosker   +7 more
doaj   +1 more source

Aggregated proteins in malignant and benign neoplasms

Experimental Oncology, 2023
Summary. Aim: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms ...
D I, Zabolotnyi, A A, Belousova, D D, Zabolotna, T D, Savchenko, N M, Voroshylova, M D, Timchenko, I R, Tsvirinko, S V, Verevka   +7 more
openaire   +2 more sources

Correlation of local and systemic expression of survivin with histopathological parameters of cutaneous melanoma [PDF]

Vojnosanitetski Pregled, 2016
Background/Aim. Survivin is a multifunctional protein abundantly expressed in tumors of various types, including melanoma. There are still sparse data regarding relationship of melanoma cell survivin expression with accepted histopathological ...
Jović Milena, Cerović Snežana, Zolotarevska Lidija, Gačević Milomir, Stanojević Ivan, Miller Karolina, Đukić Mirjana, Saso Luciano, Jauković Ljiljana, Vojvodić Danilo   +9 more
doaj   +1 more source

Estrogen-regulated proteins cathepsin D and pS2 in breast carcinoma [PDF]

Archive of Oncology, 2006
In addition to classical prognostic/predictive factors, significant biological markers have been identified to provide potentially relevant information regarding natural or clinical course of breast cancer.
Markićević Milan, Vujasinović Tijana, Nešković-Konstantinović Zora, Nikolić-Vukosavljević Dragica   +3 more
doaj   +1 more source

EPLIN, Epithelial protein lost in neoplasm [PDF]

Oncogene, 1999
We have identified a novel cytoskeletal protein, EPLIN (Epithelial Protein Lost In Neoplasm), that is preferentially expressed in human epithelial cells. Two EPLIN isoforms, a 600 amino acid EPLIN-alpha and a 759 amino acid EPLIN-beta, are detected in primary epithelial cells of oral mucosa, prostate and mammary glands. The expression of EPLIN-alpha is
R S, Maul, D D, Chang
openaire   +2 more sources

E-Cadherin expression and blunted interferon response in blastic plasmacytoid dendritic cell neoplasm [PDF]

, 2021
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive neoplasm derived from plasmacytoid dendritic cells (pDCs). In this study, we investigated by immunohistochemical analysis the expression of E-cadherin (EC) on pDCs in reactive lymph ...
Giliani S. C., Vairo D., Tomaselli M., Lorenzi L., Lonardi S., Tucci A., Vermi W., Bernardelli A., Bugatti M., Arisi M., Cerroni L., Facchetti F., Licini S.   +12 more
core   +3 more sources

The effect of resistancerelated proteins on the prognosis and survival of patients with osteosarcoma: an immunohistochemical analysis

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: Despite the developments in chemotherapy protocols, improvement in the survival rates of osteosarcoma has been limited. We evaluated the effect of certain prognosis-related proteins on survival of patients with osteosarcoma.\r\nMethods: Data ...
Harzem Ozger, Levent Eralp, Ata Can lar, Berkin Toker, Lora Esberk Ates, Mustafa Sungur, Bilge Bilgic, Inci Ayan   +7 more
doaj   +1 more source