Results 21 to 30 of about 506,616 (289)
Expression of cdc25A and cdc25B proteins in thyroid neoplasms [PDF]
British Journal of Cancer, 2002 Cdc25B and cdc25A phosphates are prominent stimulators of cell cycle progression and recent studies have also suggested their oncogenic roles. To elucidate the role of these proteins in thyroid neoplasms, we immunohistochemically investigated their expression, and neither protein was expressed in normal follicular cells.
Ito, Y +10 more
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FOP is a centriolar satellite protein involved in ciliogenesis. [PDF]
PLoS ONE, 2013 Centriolar satellites are proteinaceous granules that are often clustered around the centrosome. Although centriolar satellites have been implicated in protein trafficking in relation to the centrosome and cilium, the details of their function and ...
Joanna Y Lee, Tim Stearns
doaj +1 more source
Proteolysis-targeting chimeras and their implications in breast cancer
Exploration of Targeted Anti-tumor Therapy, 2021 Breast cancer (BC) is a highly heterogeneous neoplasm of the mammary tissue, causing the deaths of a large number of women worldwide. Nearly 70% and 20% of BC cases are estrogen receptor alpha positive (ERα+) and human epidermal growth factor receptor 2 ...
Angeles C. Tecalco-Cruz +3 more
doaj +1 more source
NDRG1 protein overexpression in malignant thyroid neoplasms [PDF]
Clinics, 2010 The aim of this study was to examine the expression of the N-myc downstream-regulated gene 1 protein in benign and malignant lesions of the thyroid gland by immunohistochemistry.N-myc downstream-regulated gene 1 encodes a protein whose expression is induced by various stimuli, including cell differentiation, exposure to heavy metals, hypoxia, and DNA ...
Gerhard, Renê +4 more
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p53 protein overexpression in astrocytic neoplasms
Yonsei Medical Journal, 1995 Abnormalities of the p53 gene are the most common molecular change in human cancer. In the central nervous system, mutant p53 gene is frequently identified in the tumors with astrocytic differentiation. To investigate the relation between histologic subtypes and p53 protein overexpression, we examined 81 cases of astrocytic neoplasms (24 benign ...
M Y, Cho, S H, Jung, T S, Kim
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Pathophysiology of elevated ascites fluid cholesterol in malignant ascites [PDF]
, 1992 The existence of marked elevations of ascitic fluid cholesterol has been observed in patients with peritoneal carcinomatosis compared to patients with cirrhosis and has been found useful in differential diagnosis.
Jüngst, Dieter +2 more
core +1 more source
Medicina, 2023 Background and Objectives: Papillary thyroid carcinoma (PTC) is one of the most common malignancies of the endocrine system. In order to improve the ability to predict tumor behavior, several studies have been conducted to search for surrogate prognostic
Mohammad Sheikh-Ahmad +10 more
doaj +1 more source
Molecular Cancer, 2023 Aim Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC chemoresistance was investigated using in silico, in vitro, and in vivo approaches.
Sandra Kendzia +28 more
doaj +1 more source
Frontiers in Oncology, 2020 Uveal melanoma, in spite of its rarity, represents the most common primitive intraocular malignant neoplasm of the adults; it affects choroid, ciliary bodied and iris and remains clinically silent for a long time, being accidentally discovered by routine
Giuseppe Broggi +11 more
doaj +1 more source
Nonimmune fluorescent protein staining of neoplasms [PDF]
Experimental and Molecular Pathology, 1963 Abstract The nonimmunospecific tissue binding of protein-fluorochrome conjugates has been investigated. Such binding was specific in attachment to benign tissue, excluding malignant tissue, when fluorescein or rhodamine isocyanate was use according to the method of Hughes and Louis (1959) .
Miller, Edmund Kenneth +3 more
openaire +2 more sources