Results 21 to 30 of about 494,128 (290)

A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer

open access: yesMolecular Cancer, 2023
Aim Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC chemoresistance was investigated using in silico, in vitro, and in vivo approaches.
Sandra Kendzia   +28 more
doaj   +1 more source

p53 protein overexpression in astrocytic neoplasms

open access: yesYonsei Medical Journal, 1995
Abnormalities of the p53 gene are the most common molecular change in human cancer. In the central nervous system, mutant p53 gene is frequently identified in the tumors with astrocytic differentiation. To investigate the relation between histologic subtypes and p53 protein overexpression, we examined 81 cases of astrocytic neoplasms (24 benign ...
M Y, Cho, S H, Jung, T S, Kim
openaire   +2 more sources

The Macro-Autophagy-Related Protein Beclin-1 Immunohistochemical Expression Correlates With Tumor Cell Type and Clinical Behavior of Uveal Melanoma

open access: yesFrontiers in Oncology, 2020
Uveal melanoma, in spite of its rarity, represents the most common primitive intraocular malignant neoplasm of the adults; it affects choroid, ciliary bodied and iris and remains clinically silent for a long time, being accidentally discovered by routine
Giuseppe Broggi   +11 more
doaj   +1 more source

Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor

open access: yesBiomolecules & Biomedicine, 2012
Interdigitating dendritic cell sarcoma is extremely rare neoplasm that mainly occurs in the lymph nodes. Only 45 cases have been reported in the literature to date.
Svjetlana Radović   +6 more
doaj   +1 more source

Faecal Proteomics and Functional Analysis of Equine Melanocytic Neoplasm in Grey Horses

open access: yesVeterinary Sciences, 2022
Equine melanocytic neoplasm (EMN) is a common disease in older grey horses. The purpose of this study was to examine the potential proteins throughout EMN stages from faecal proteomic outlining using functional analysis.
Parichart Tesena   +6 more
doaj   +1 more source

Candidate protein biomarkers in pancreatic neuroendocrine neoplasms grade 3 [PDF]

open access: yesScientific Reports, 2020
AbstractPancreatic neuroendocrine neoplasms (PanNENs) are rare tumours that compose 1–2% of all pancreatic tumours. Patients with metastatic grade 3 neoplasia are usually treated with chemotherapy but have a poor progression-free and overall survival. According to the WHO 2017 classification, they are divided into neuroendocrine tumours (NETs) G3 and ...
Ali, Abir Salwa   +6 more
openaire   +4 more sources

Characteristics and clinical significance of polyploid giant cancer cells in laryngeal carcinoma

open access: yesLaryngoscope Investigative Otolaryngology, 2021
Objectives We aimed to construct an induction system for polyploid giant cancer cells (PGCCs), as well as to investigate PGCC features and clinical significance.
Hui‐Ting Liu   +9 more
doaj   +1 more source

Molecular markers of recurrence of basal cell skin cancer [PDF]

open access: yesVestnik Dermatologii i Venerologii, 2023
Basal cell carcinoma is the most common malignant neoplasm, andits incidence has been rapidly increasing worldwide. This malignancy is a serious public health problem that can lead to disability and severe aesthetic damage. The results of the analysis
Rifat R. Saytburkhanov   +3 more
doaj   +1 more source

Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus Hürthle Cell Neoplasms: A Retrospective Analysis [PDF]

open access: yesDisease Markers, 2017
Purpose. Although currently classified as variants of follicular neoplasms (FNs), Hürthle cell neoplasms (HCNs) exhibit distinct biological characteristics. Hence, the metabolism of both neoplasms may also be different. The aims of this study were to investigate and compare the expression of glycolysis-related proteins in HCNs and FNs and to determine ...
Hye Min Kim, Ja Seung Koo
openaire   +3 more sources

Myeloid transformation of plasma cell myeloma: molecular evidence of clonal evolution revealed by next generation sequencing

open access: yesDiagnostic Pathology, 2018
Background Plasma cell myeloma (PCM) is a neoplasm of terminally differentiated B lymphocytes with molecular heterogeneity. Although therapy-related myeloid neoplasms are common in plasma cell myeloma patients after chemotherapy, transdifferentiation of ...
Jonathon H. Gralewski   +3 more
doaj   +1 more source

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