Results 121 to 130 of about 1,599,346 (327)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Treatment of corneoscleral mixed hemangioma by intrastromal lenticule transplantation in a case of xeroderma pigmentosum: a case report

BMC Ophthalmology
Background Xeroderma pigmentosum (XP) is a rare autosomal recessive skin disease. The ocular manifestations in XP patients usually include severe photophobia, conjunctivitis, corneal opacification, ocular surface squamous neoplasia (OSSN) which often ...
Yingwei Wang, Li Cai, Hua Feng, Xiaofei Wu, Hongmin Ke, Jerry Ma, Wanmei Tang, Kunling Chen, Qiong Wang   +8 more
doaj   +1 more source

Seronegative Herpes simplex Associated Esophagogastric Ulcer after Liver Transplantation

Case Reports in Gastroenterology, 2008
Herpes simplex infection is characterized by acute or subacute infection, often followed by a chronic carrier state. Consecutive recurrences may flare up if immunocompromise occurs.
Edouard Matevossian, Dietrich Doll, Gregor Weirich, Maria Burian, Carolin Knebel, Stefan Thorban, Norbert Hüser   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report [PDF]

, 2017
This Center for International Blood and Marrow Transplant Research report describes the use of hematopoietic stem cell transplantation (HSCT) in pediatric patients with cancer, 4408 undergoing allogeneic (allo) and3076 undergoing autologous (auto) HSCT ...
Thiel, Elizabeth,, Hale, Gregory A, Ka Wah Chan, Chaudhury, Sonali,, Gadalla, Shahinaz M.,, Chan, Ka Wah, Bruce M. Camitta, Carrie L. Kitko, Chan, Ka Wah,, Gregory Hale, Olsson, Richard F, Wirk, Baldeep,, Millard, Heather R, Miguel Angel-Diaz, Olsson, Richard,, Keating, Amy K.,, Page, Kristin M.,, Kasow, Kimberly Anne, Khandelwal, Pooja,, Cowan, Morton J.,, Brown, Valerie I, Warwick, Anne B, Seber, Adriana,, Camitta, Bruce M, Kimberly A. Kasow, Margaret L. MacMillan, Abraham, Allistair A, Kasow, Kimberly A.,, Auletta, Jeffery J, Sonali Chaudhury, Seber, Adriana, Abraham, Allistair A.,, Abdel-Azim, Hisham, Diaz Perez, Miguel Angel, Robert Peter Gale, Kitko, Carrie L.,, Shahinaz M. Gadalla, MacMillan, Margaret L.,, Pooja Khandelwal, Hale, Gregory,, Parinda A. Mehta, Wirk, Baldeep, Auletta, Jeffery J.,, Farid Boulad, Morton J. Cowan, Page, Kristin M, Boulad, Farid,, Allistair A. Abraham, Gadalla, Shahinaz M, Mehta, Parinda A, Hale, Gregory, Richard F. Olsson, Jeffery J. Auletta, Valerie I. Brown, Heather R. Millard, Angel-Diaz, Miguel,, Hisham Abdel-Azim, Angela R. Smith, Brown, Valerie I.,, Smith, Angela R.,, Kristin M. Page, Thiel, Elizabeth, Keating, Amy K, Wirk, Baldeep M, Millard, Heather R.,, Elizabeth Thiel, Mehta, Parinda A.,, Angel-Diaz, Miguel, Smith, Angela R, Chaudhury, Sonali, Baldeep Wirk, Gale, Robert Peter, Kasow, Kimberly A, Gale, Robert Peter,, Anne B. Warwick, Kitko, Carrie L, Camitta, Bruce M.,, Warwick, Anne B.,, Cowan, Morton J, Amy K. Keating, MacMillan, Margaret L, Khandelwal, Pooja, Abdel-Azim, Hisham,, Adriana Seber, Boulad, Farid   +84 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Effect of mechanistic target of rapamycin inhibitors on postrenal transplantation malignancy: A nationwide cohort study

Cancer Medicine, 2018
Background Post‐transplantation malignancy influenced graft survival and overall survival in the patients receiving renal transplantation. Immunosuppressants influenced the immune surveillance, but whether immunosuppressive agents have impact for ...
Yi‐Chou Hou, Yen‐Chen Chang, Hao‐Lun Luo, Kuo‐Cheng Lu, Po‐Huang Chiang   +4 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source