Results 111 to 120 of about 624,041 (256)

Effect of mechanistic target of rapamycin inhibitors on postrenal transplantation malignancy: A nationwide cohort study

Cancer Medicine, 2018
Background Post‐transplantation malignancy influenced graft survival and overall survival in the patients receiving renal transplantation. Immunosuppressants influenced the immune surveillance, but whether immunosuppressive agents have impact for ...
Yi‐Chou Hou, Yen‐Chen Chang, Hao‐Lun Luo, Kuo‐Cheng Lu, Po‐Huang Chiang   +4 more
doaj   +1 more source

Blastic plasmacytoid dendritic cell neoplasm

, 2013
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematological malignancy that originates from the precursors of plasmacytoid dendritic cells.
Hugh Goodman (15918467), Marius Rademaker (511790), Duncan Lamont (15918470), David Lim (6727001), Alison Yung (13100928)   +4 more
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Living-Related Liver Transplantation. Progress, Pitfalls, and Promise

, 2014
The first living-donor liver transplantation (LDLT) was performed in 1988. Since then the procedure has been developed especially in Asian countries to alleviate the problem of postmortem organ shortage.
Lerut, Jan, Quirino , Lai, Lai Quirino., P. Lerut Jan, Lai Quirino, Lerut Jan P.   +5 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Managing Juvenile Myelomonocytic Leukemia in Resource-Constraint Setting: New Hope with Isotretinoin-based Cytoreductive Therapy

Haematology Journal of Bangladesh
Juvenile myelomonocytic leukaemia (JMML) is a highly aggressive myeloid neoplasm of early childhood. Currently the only curative treatment for this potentially fatal disease is haematopoietic stem cell transplantation (HSCT), but cure rate is only 50 ...
Eshita Reza Khan, Ferdousi Begum, Sabina Karim   +2 more
doaj   +1 more source

Fewer Islets Survive from a First Transplant than a Second Transplant : Evaluation of Repeated Intraportal Islet Transplantation in Mice

, 2019
Beta cell replacement is an exciting field where new beta cell sources and alternative sites are widely explored. The liver has been the implantation site of choice in the clinic since the advent of islet transplantation. However, in most cases, repeated
Carlsson, Per-Ola,, Liljebäck, Hanna,, Lau, Joey,, Quach, My, Quach, My,, Lau, Joey, Carlsson, Per-Ola, Liljebäck, Hanna   +7 more
core   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury [PDF]

, 2012
The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between ...
Ryan, Michael P., Johnston, Olwyn, Slattery, Craig, Cassidy, Hilary, McMorrow, Tara   +4 more
core  

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source