Results 91 to 100 of about 597,042 (307)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Renal Transplantation with Kidneys Affected by Tumours

International Journal of Nephrology, 2010
Renal transplantation confers improvement in quality of life and survival when compared to patients on dialysis. There is a universal shortage of organs, and efforts have been made to overcome this shortage by exploring new sources.
Muhammad Arslan Khurram, Aliu Oladipupo Sanni, David Rix, David Talbot   +3 more
doaj   +1 more source

Rare myeloid sarcoma/acute myeloid leukemia with adrenal mass after allogeneic mobilization peripheral blood stem cell transplantation

Cancer Biology & Medicine, 2013
Myeloid sarcoma (MS) is a rare hematological neoplasm that develops either de novo or concurrently with acute myeloid leukemia (AML). This neoplasm can also be an initial manifestation of relapse in a previously treated AML that is in remission.
Ya-Fei Wang, Qian Li, Wen-Gui Xu, Jian-Yu Xiao, Qing-Song Pang, Qing Yang, Yi-Zuo Zhang   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Aplication of two-staged plasty for postoperative defect after Buschke – Löwenstein tumor removal

Инновационная медицина Кубани, 2019
The pointed condylomas caused by human papilloma virus (HPV) are more common seen among infections of anogenital area and they are sexually transmitted.
A. G. Baryshev, V. V. Polovinkin, A. S. Dikarev, S. B. Bogdanov, N. V. Khachaturyan, D. A. Valyakis, I. V. Pavlov, A. J. Mostovaya   +7 more
doaj   +2 more sources

Intracranial transplantation of the tumor induced by adenovirus type 12 in Syrian hamster--an experimental brain tumor model [PDF]

, 1971
A method of intracranial transplantation of the tumor induced by adenovirus type 12 in syrian hamster has been described. The incidence of intracranial tumor development was 86 (90.5 %) out of 95 animals and the average survival time and tumor size at ...
Tabuchi, Kazuo
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Organoid Culture of Isolated Cells from Patient-derived Tissues with Colorectal Cancer

Chinese Medical Journal, 2016
Background: Colorectal cancer (CRC) is a heterogeneous disease; current research relies on cancer cell lines and animal cancer models, which may not precisely imitate inner human tumors and guide clinical medicine. The purpose of our study was to explore
Bing-Ying Xie, Ai-Wen Wu
doaj   +1 more source

Protocol TOP-Study (tacrolimus organ perfusion): a prospective randomized multicenter trial to reduce ischemia reperfusion injury in transplantation of marginal liver grafts with an "ex vivo" tacrolimus perfusion [PDF]

, 2013
Background: Critical organ shortage results in the utilization of extended donor criteria (EDC) liver grafts. These marginal liver grafts are prone to increased ischemia reperfusion injury (IRI) which may contribute to deteriorated graft function and ...
Jauch, Karl-Walter, Silvio Nadalin, Karl-Walter Jauch, Heise, Michael, Martin K Angele, Pratschke, Sebastian, Wolters, Heiner, Angele, Martin Kurt, Ulrich, Frank, Schemmer, Peter, Michael Heise, Dirk Wöhling, Angele, Martin K., Wöhling, Dirk, Sebastian Pratschke, Michael Eder, Nadalin, Silvio, Marcus N Scherer, Heiner Wolters, Andreas Pascher, Peter Schemmer, Scherer, Marcus N., Eder, Michael, Pascher, Andreas, Frank Ulrich   +24 more
core   +1 more source