Results 51 to 60 of about 597,042 (307)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Acral myxoinflammatory fibroblastic sarcoma with hybrid features of hemosiderotic fibrolipomatous tumor occurring 10 years after renal transplantation

Rare Tumors, 2018
Myxoinflammatory fibroblastic sarcoma is a rare malignant soft tissue neoplasm that typically arises on the distal extremities of adults. It usually behaves in a low-grade manner and its characteristic histology is of a lobulated proliferation of ...
Magnus Hallin, Yurina Miki, Andrew J Hayes, Robin L Jones, Cyril Fisher, Khin Thway   +5 more
doaj   +1 more source

Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia. [PDF]

PLoS ONE, 2015
Juvenile myelomonocytic leukemia (JMML), an overlap of myelodysplastic / myeloproliferative neoplasm, is an intractable pediatric myeloid neoplasm. Epigenetic regulation of transcription, particularly by CpG methylation, plays an important role in tumor ...
Hirotoshi Sakaguchi, Hideki Muramatsu, Yusuke Okuno, Hideki Makishima, Yinyan Xu, Yoko Furukawa-Hibi, Xinan Wang, Atsushi Narita, Kenichi Yoshida, Yuichi Shiraishi, Sayoko Doisaki, Nao Yoshida, Asahito Hama, Yoshiyuki Takahashi, Kiyofumi Yamada, Satoru Miyano, Seishi Ogawa, Jaroslaw P Maciejewski, Seiji Kojima   +18 more
doaj   +1 more source

Non HIV oral Kaposi Sarcoma: Rare case report literature review

Advances in Oral and Maxillofacial Surgery, 2022
Kaposi Sarcoma (KS) is an intermediate neoplasm affecting the endothelial cells of mucous membranes and skin. It arises most commonly among HIV-infected individuals. Oral Kaposi's sarcoma of a HIV seronegative patient is extremely rare.
Harrizi Meriem, Mounia EL. Bouhairi, Ihsane Ben Yahya   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation

Case Reports in Hematology, 2020
ALK-negative anaplastic large cell lymphoma is a rare T-cell neoplasm with an aggressive course requiring prompt diagnostic work-up and treatment. Few cases of concomitant multiple myeloma and T-cell neoplasm are described in the literature, mainly ...
Michela Staderini, Lara Mannelli, Elisabetta Antonioli, Benedetta Puccini, Valentina Berti, Francesco Mungai, Federica Vergoni, Valentina Carrai, Luigi Rigacci, Alberto Bosi   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Risk factors for relapse after allogeneic transplantation in acute myeloid leukemia

Haematologica, 2016
Acute myeloid leukemia is a clonal neoplasm derived from myeloid progenitor cells with a varying outcome. The initial goal of treatment is the achievement of complete remission, defined for over 40 years by morphology.
Gert J. Ossenkoppele, Jeroen J.W.M. Janssen, Arjan A. van de Loosdrecht   +2 more
doaj   +1 more source

Anesthesia and Critical Care for the Prediction and Prevention for Small-for-size Syndrome: Guidelines from the ILTS-iLDLT-LTSI Consensus Conference

, 2023
BACKGROUND: During the perioperative period of living donor liver transplantation, anesthesiologists and intensivists may encounter patients in receipt of small grafts that puts them at risk of developing small for size syndrome (SFSS).
Egawa, H., Humar, A., Clavien, Pierre-Alain, Rammohan, Ashwin, Shah, Samir, Ascher, N., Clavien, P. A., Lerut, Jan, Rajakumar, A., Cattral, M., Sun, L. Y., Saigal, S., Clemens Broering, D., Kumar, Lakshmi, Clemens Broering, Dieter, Chen, Chao-Long, Bezinover, Dmitri, Findlay, J., Yi, Nam-Joon, Yoon, U., Spiro, Michael, Egawa, Hiroto, Patel, D., Yi, N. J., Kumar, L., Agarwal, Shaleen, Patel, Dhupal, Sun, Li-Ying, Humar, Abhinav, Singh, Shweta, Bhangui, P., Rajakumar, Akila, Yoon, Uzung, Kumaran, Vinay, Lerut, J., Rammohan, A., Shingina, Alexandra, Shingina, A., Bhangui, Prashant, Singh, S., Berlakovich, G., Emond, J., Chadha, Ryan, Zhu, Z. J., Saigal, Sanjiv, Chen, C. L., Rela, M., Rodriguez-Davalos, M., Sakai, Tetsuro, Bezinover, D., Shah, S., Emond, Jean, Agarwal, S., Chadha, R., Ascher, Nancy, Bhangui, Pooja, Berlakovich, Gabriela, Rodriguez-Davalos, Manuel, Rela, Mohamed, Spiro, M., Zhu, Zhi-Jun, Cattral, Mark, Sakai, T., Berenguer, M., Findlay, James, Kumaran, V., Berenguer, Marina   +66 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source