Results 61 to 70 of about 153,171 (297)

Interleukin 2 as a potential cancer marker in patients after kidney transplantation [PDF]

, 2015
Introduction Transplant recipients have a significantly greater incidence of cancer, compared with the general population, who are referred to immunosuppressive therapy as an additional malignancy risk factor.
Sylwia Gorczynska-Kosiorz, Magdalena Kimsa, Zywiec, J., Urszula Mazurek, Janusz Gumprecht, Barbara Strzalka-Mrozik, Gorczynska-Kosiorz, S., Mazurek, U., Magdalena Kimsa, Joanna Zywiec, Grzeszczak, W., Władysław Grzeszczak, Aleksander Owczarek, Joanna Zywiec, Strzalka-Mrozik, B., Owczarek, A., Agnieszka Strozik, Urszula Mazurek, Stepien, B., Wanda Trautsolt, Beata Stępień, Trautsolt, W., Agnieszka Witkowska, Witkowska, A., Kimsa, M., Janusz Gumprecht, Gumprecht, J., Władysław Grzeszczak, Sylwia Gorczynska-Kosiorz, Agnieszka Witkowska, Agnieszka Strozik, Strozik, A., Barbara Strzalka-Mrozik, Aleksander Owczarek, Wanda Trautsolt, Beata Stępień   +35 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Blastic plasmacytoid dendritic cell neoplasm presenting as leukemia without cutaneous involvement in a 25 years male patient: Unusual presentation of a rare entity

Indian Journal of Pathology and Microbiology, 2015
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive neoplasm classified under "acute myeloid leukemia (AML) and related precursor neoplasm" by current WHO classification.
Sumaira Qayoom, Garima Durga, Seena George, Khaliqur Rahman   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Allogeneic Hematopoietic Cell Transplantation for Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

, 2021
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is an aggressive hematological malignancy; however, some patients achieve durable remission with allogeneic hematopoietic cell transplantation (allo-HCT).
Shpall, Elizabeth J, Nieto, Yago, Milton, Denái R, Khouri, Issa F., Bashir, Qaiser, Srour, Samer A, Shpall, Elizabeth J., Srour, Samer A., Popat, Uday R., Oran, Betul, Khouri, Issa F, Hosing, Chitra, Al-Atrash, Gheath, Champlin, Richard E., Olson, Amanda L, Kebriaei, Partow, Pemmaraju, Naveen, Rezvani, Katayoun, Qazilbash, Muzaffar H, Konopleva, Marina Y, Popat, Uday R, Saini, Neeraj Y, Milton, Denái R., Qazilbash, Muzaffar H., Champlin, Richard E, Rondon, Gabriela, Olson, Amanda L., Saini, Neeraj Y., Ahmed, Sairah, Konopleva, Marina Y.   +29 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Aggressive NK-cell leukemia: A rare entity with diagnostic and therapeutic challenge

Human Pathology: Case Reports, 2016
Aggressive natural killer cell leukemia (ANKL) is a rare neoplasm of mature natural killer cells, with an extremely poor overall survival, which is almost always EBV related, with majority of cases reported in East Asia.
Alia Nazarullah, Michelle Don, Yuliya Linhares, Serhan Alkan, Qin Huang   +4 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Liver transplantation for neuroendocrine neoplasms liver metastases

Liver transplantation (LT) can be proposed for a selected group of patients with Neuroendocrine neoplasm liver metastases (NELM) that fulfill the well-established selection criteria. Indeed, outcomes of LT for NELM have improved after the introduction of
Coubeau, Laurent, Bonaccorsi Riani, Eliano   +1 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source