Results 31 to 40 of about 3,994 (207)

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, Volume 103, Issue 4, Page 540-566, October 2025.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

Características clínico-patológicas de los pacientes asistidos en el Centro Docente Asociado de Oncología Médica en el Hospital Departamental de Soriano durante su primer año de funcionamiento.

Anales de la Facultad de Medicina, 2023
Introducción: Según el Ministerio de Salud las muertes por cáncer constituyen un cuarto del total de las defunciones registradas en Uruguay cada año. Objetivo: Conocer el perfíl epidemiológico de los pacientes diagnosticados de cáncer asistidos en el ...
Natalia Camejo, Noelia Strazzarino, Valeria Rodriguez Saenz, Lujan Cabrera, Joselina Ibarburu, Cecilia Castillo, Dahiana Amarillo, Carolina Dörner, Gabriel Krygier   +8 more
doaj   +1 more source

Perda do cromossoma Y versus doenças hematológicas malignas [PDF]

, 2013
A associação clínica entre a perda do cromossoma Y (PY) e as doenças hematológicas malignas é um tema controverso, uma vez que ambos os acontecimentos estão correlacionados com o envelhecimento.
Ambrósio, Ana Paula, Correia, Hildeberto, Furtado, José, Silva, Maria do Céu   +3 more
core  

Mortality trends among brazilian women in the climacteric [PDF]

, 2008
Há poucos estudos sobre mortalidade feminina durante o climatério, em especial no Brasil. O objetivo deste estudo foi analisar a tendência de mortalidade em mulheres de 35 a 64 anos no Brasil nos últimos anos.
ALDRIGHI, José Mendes, CARDOSO, Maria Regina Alves, SCHMITT, Ana Carolina Basso   +2 more
core   +2 more sources

Somatic co‐alteration signatures are prognostic in high‐grade TP53‐mutated myeloid neoplasms

British Journal of Haematology, Volume 206, Issue 4, Page 1103-1108, April 2025.
Summary To assess the relevance of co‐occurring somatic mutations in TP53‐mutated myeloid neoplasms with ≥10% blasts, we pooled 325 individuals from 10 centres. We focused on comparing three published somatic co‐alteration signatures comprising (1) nine MDS‐related genes (‘ICC‐MDSR’), (2) ICC‐MDSR + additional secondary mutations‐related genes (‘Tazi ...
Emily O. Symes, Peng Wang, Payal Sojitra, Madhu P. Menon, Anand A. Patel, Faheema Hasan, Sharmila Ghosh, Gregory W. Roloff, Qianghua Zhou, Anthony Findley, Talha Badar, Jingjing Zhang, Hamza Tariq, Hong Chang, Robert C. Bell, Anamarija M. Perry, Girish Venkataraman   +16 more
wiley   +1 more source

The genetic duet of concurrent RASAL1 and PTEN alterations promotes cancer aggressiveness by cooperatively activating the PI3K–AKT pathway

Molecular Oncology, Volume 19, Issue 1, Page 248-259, January 2025.
Comprehensive analyses of TCGA revealed common coexisting RASAL1 and PTEN alterations and their association with over‐activation of the PI3K–AKT pathway and poor clinical outcomes of cancer, which was recapitulated in mice with double Rasal1–Pten knockout and worsened by coexisting TP53 alterations.
Xiaopei Shen, Jie Tan, Rengyun Liu, Guangwu Zhu, Lisa Rooper, Mingzhao Xing   +5 more
wiley   +1 more source

Successful treatment of young childhood standard‐risk hepatoblastoma with cisplatin monotherapy using a central review system

Pediatric Blood &Cancer, Volume 71, Issue 11, November 2024.
Abstract Background The JPLT3‐S (Japanese Study Group for Pediatric Liver Tumors‐3) study, conducted cisplatin (CDDP) monotherapy for young children (<3 years old) with standard‐risk hepatoblastoma (HB) using a central review system in Japan. In the previous JPLT2 study, cases with resectable tumors without any annotation factors in the PRETEXT ...
Isamu Saeki, Kohmei Ida, Sho Kurihara, Kenichiro Watanabe, Makiko Mori, Tomoro Hishiki, Akiko Yokoi, Junya Fujimura, Shohei Honda, Yuki Nogami, Tomoko Iehara, Takuro Kazama, Masahiro Sekiguchi, Norihiko Kitagawa, Risa Matsumura, Motonari Nomura, Yohei Yamada, Ryo Hanaki, Hide Kaneda, Yuichi Takama, Takeshi Inoue, Yukichi Tanaka, Osamu Miyazaki, Hiroki Nagase, Tetsuya Takimoto, Kenichi Yoshimura, Eiso Hiyama   +26 more
wiley   +1 more source

A review of the current treatment methods for retroperitoneal fibrosis with obstructive uropathy

BJUI Compass, Volume 5, Issue 8, Page 835-845, August 2024.
Abstract Introduction and aims Retroperitoneal fibrosis (RPF) is a fibroinflammatory disease in which patients may suffer obstructive uropathy (OU). The optimum treatment strategy for RPF with secondary OU is currently unclear, and the aim of this literature review is to assess the methods used to treat this patient cohort.
Charles Carey, Gerard Gurumurthy, Richard Napier‐Hemy, Bachar Zelhof   +3 more
wiley   +1 more source

Perbedaan Kadar Bilirubin Serum antara Kelompok Patologi Neoplasma dan Non-neoplasma pada Ikterus Obstruktif

Jurnal Ilmu Kesehatan Indonesia, 2022
Latar Belakang: Ikterus obstruktif merupakan kondisi dari adanya kelainan yang menyebabkan obstruksi pada sistem bilier. Salah satu pemeriksaan awal dan rutin yang dilakukan untuk membedakan kelainan yang menyebabkan ikterus adalah pemeriksaan kadar bilirubin serum.
Ilma Fitri Sakina, Avit Suchitra, Yenita Yenita   +2 more
openaire   +2 more sources

Caracterização de uma duplicação do braço longo do cromossoma 1,por microarray de alta resolução, em mielofibrose primária: um fator de malignidade? [PDF]

, 2012
Os neoplasmas mieloproliferativos (NMP) são caracterizados por uma excessiva proliferação de uma ou mais linhagens da série mieloide. A mielofibrose primária (MFP) é uma das patologias deste grupo, que apresenta uma proliferação preferencial de ...
Ambrósio, Ana Paula, Correia, Hildeberto, Marques, Bárbara, Silva, Elizabeth, Silva, Maria Céu, Trindade, Maria Céu, Ventura, Catarina, Vieira, Luís   +7 more
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