Results 1 to 10 of about 9,443,378 (317)

Experimental Modeling of Myeloproliferative Neoplasms

Genes, 2019
Myeloproliferative neoplasms (MPN) are genetically very complex and heterogeneous diseases in which the acquisition of a somatic driver mutation triggers three main myeloid cytokine receptors, and phenotypically expresses as polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (PMF).
Lucie Lanikova, Olga Babosova, Josef T. Prchal   +2 more
openaire   +3 more sources

Tobacco experimental model to induce urinary bladder neoplasms [PDF]

Revista do Colégio Brasileiro de Cirurgiões, 2014
OBJECTIVE: to develop an experimental model of exposure to tobacco burning (cigarette) products to assess the effects of its chronic use in relation to cancers of the bladder.
José Alexandre Colli Neto, José Hélio Zen Júnior, André Del Negro, Nelson Adami Andreollo, Marina Rachel Araujo, Alfio José Tincani   +5 more
doaj   +4 more sources

Inhibitory Effects of Metformin for Pancreatic Neuroendocrine Neoplasms: Experimental Study on Mitochondrial Function

Onco
Although pancreatic neuroendocrine neoplasms (panNENs) are much less common and have a better prognosis than exocrine pancreatic cancers, their recurrence rate is not low, even in Grade 1 (World Health Organization classification) panNEN. Recently, there
Shogo Maruzen, Seiichi Munesue, Mitsuyoshi Okazaki, Satoshi Takada, Shinichi Nakanuma, Isamu Makino, Linxiang Gong, Susumu Kohno, Chiaki Takahashi, Hidehiro Tajima, Yasuhiko Yamamoto, Shintaro Yagi   +11 more
doaj   +2 more sources

Nanopore sequencing for the screening of myeloid and lymphoid neoplasms with eosinophilia and rearrangement of PDGFRα, PDGFRβ, FGFR1 or PCM1-JAK2

Biomarker Research, 2021
Eosinophilia represents a group of diseases with heterogeneous pathobiology and clinical phenotypes. Among the alterations found in primary Eosinophilia, gene fusions involving PDGFRα, PDGFRβ, FGFR1 or JAK2 represent the biomarkers of WHO-defined ...
Simone Romagnoli, Niccolò Bartalucci, Francesca Gesullo, Manjola Balliu, Stefania Bonifacio, Anair Graciela Lema Fernandez, Francesco Mannelli, Davide Bolognini, Elisabetta Pelo, Cristina Mecucci, Paola Guglielmelli, Alessandro Maria Vannucchi   +11 more
doaj   +1 more source

JAK2V617F variant allele frequency >50% identifies patients with polycythemia vera at high risk for venous thrombosis

Blood Cancer Journal, 2021
Arterial (AT) and venous (VT) thrombotic events are the most common complications in patients with polycythemia vera (PV) and are the leading causes of morbidity and mortality.
Paola Guglielmelli, Giuseppe G. Loscocco, Carmela Mannarelli, Elena Rossi, Francesco Mannelli, Francesco Ramundo, Giacomo Coltro, Silvia Betti, Chiara Maccari, Sara Ceglie, Patrizia Chiusolo, Chiara Paoli, Tiziano Barbui, Ayalew Tefferi, Valerio De Stefano, Alessandro M. Vannucchi   +15 more
doaj   +1 more source

Accuracy of B-mode ultrasonography for detecting malignancy in canine cutaneous neoplasms: preliminary results [PDF]

Pesquisa Veterinária Brasileira, 2021
: The aim of this study was to verify the applicability and accuracy of B-mode ultrasonography in detecting malignancy in dog cutaneous neoplasms. Forty-two neoplasms (12 benign and 30 malignant) of mesenchymal, round cells, epithelial and melanocytic ...
Igor C.K. da Cruz, Maria L.A. Mestieri, João P.E. Pascon, Mauren P. Emanuelli, Maria E. Trost, Etiele M. Gomes, Ingrid R.L. Machado   +6 more
doaj   +1 more source

Assessment of deep neural networks for the diagnosis of benign and malignant skin neoplasms in comparison with dermatologists: A retrospective validation study

PLoS Medicine, 2020
Background The diagnostic performance of convolutional neural networks (CNNs) for diagnosing several types of skin neoplasms has been demonstrated as comparable with that of dermatologists using clinical photography.
S. Han, I. Moon, Seong Hwan Kim, J. Na, M. Kim, Gyeong-Hun Park, I. Park, Keewon Kim, Woohyung Lim, J. H. Lee, S. Chang   +10 more
semanticscholar   +1 more source

Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)

Clinical Cancer Research, 2020
Purpose: GEP-NENs are rare malignancies with increasing incidence. Their molecular characteristics are still undefined. We explored the underlying biology of GEP-NENs and the differences between gastrointestinal (GI) and pancreatic (PNEN), high-grade (HG)
A. Puccini, K. Poorman, M. Salem, Davide Soldato, A. Seeber, R. Goldberg, A. Shields, J. Xiu, F. Battaglin, M. D. Berger, R. Tokunaga, M. Naseem, A. Barzi, S. Iqbal, Wu Zhang, S. Soni, Jimmy J. Hwang, P. Philip, S. Sciallero, W. Korn, J. Marshall, H. Lenz   +21 more
semanticscholar   +1 more source

Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells

Frontiers in Immunology, 2023
Transplantation of hematopoietic stem cells (HSCT) is a procedure commonly used in treatment of various haematological disorders which is associated with significantly improved survival rates.
Jagoda Siemaszko, Piotr Łacina, Donata Szymczak, Agnieszka Szeremet, Maciej Majcherek, Anna Czyż, Małgorzata Sobczyk-Kruszelnicka, Wojciech Fidyk, Iwona Solarska, Barbara Nasiłowska-Adamska, Patrycja Skowrońska, Maria Bieniaszewska, Agnieszka Tomaszewska, Grzegorz W. Basak, Sebastian Giebel, Tomasz Wróbel, Katarzyna Bogunia-Kubik   +16 more
doaj   +1 more source

Neutrophil-to-lymphocyte ratio is a novel predictor of venous thrombosis in polycythemia vera

Blood Cancer Journal, 2022
We investigated the neutrophil-to-lymphocyte ratio (NLR) as a predictor of thrombosis in polycythemia vera (PV). After a median follow-up of 2.51 years, of 1508 PV patients enrolled in the ECLAP study, 82 and 84 developed arterial and venous thrombosis ...
Alessandra Carobbio, Alessandro Maria Vannucchi, Valerio De Stefano, Arianna Masciulli, Paola Guglielmelli, Giuseppe Gaetano Loscocco, Francesco Ramundo, Elena Rossi, Yogendra Kanthi, Ayalew Tefferi, Tiziano Barbui   +10 more
doaj   +1 more source