Results 1 to 10 of about 8,440,114 (317)

Experimental Modeling of Myeloproliferative Neoplasms

Genes, 2019
Myeloproliferative neoplasms (MPN) are genetically very complex and heterogeneous diseases in which the acquisition of a somatic driver mutation triggers three main myeloid cytokine receptors, and phenotypically expresses as polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (PMF).
Lucie Lanikova, Olga Babosova, Josef T. Prchal   +2 more
openaire   +3 more sources

Tobacco experimental model to induce urinary bladder neoplasms [PDF]

Revista do Colégio Brasileiro de Cirurgiões, 2014
OBJECTIVE: to develop an experimental model of exposure to tobacco burning (cigarette) products to assess the effects of its chronic use in relation to cancers of the bladder.
José Alexandre Colli Neto, José Hélio Zen Júnior, André Del Negro, Nelson Adami Andreollo, Marina Rachel Araujo, Alfio José Tincani   +5 more
doaj   +4 more sources

Nanopore sequencing for the screening of myeloid and lymphoid neoplasms with eosinophilia and rearrangement of PDGFRα, PDGFRβ, FGFR1 or PCM1-JAK2

Biomarker Research, 2021
Eosinophilia represents a group of diseases with heterogeneous pathobiology and clinical phenotypes. Among the alterations found in primary Eosinophilia, gene fusions involving PDGFRα, PDGFRβ, FGFR1 or JAK2 represent the biomarkers of WHO-defined ...
Simone Romagnoli, Niccolò Bartalucci, Francesca Gesullo, Manjola Balliu, Stefania Bonifacio, Anair Graciela Lema Fernandez, Francesco Mannelli, Davide Bolognini, Elisabetta Pelo, Cristina Mecucci, Paola Guglielmelli, Alessandro Maria Vannucchi   +11 more
doaj   +1 more source

JAK2V617F variant allele frequency >50% identifies patients with polycythemia vera at high risk for venous thrombosis

Blood Cancer Journal, 2021
Arterial (AT) and venous (VT) thrombotic events are the most common complications in patients with polycythemia vera (PV) and are the leading causes of morbidity and mortality.
Paola Guglielmelli, Giuseppe G. Loscocco, Carmela Mannarelli, Elena Rossi, Francesco Mannelli, Francesco Ramundo, Giacomo Coltro, Silvia Betti, Chiara Maccari, Sara Ceglie, Patrizia Chiusolo, Chiara Paoli, Tiziano Barbui, Ayalew Tefferi, Valerio De Stefano, Alessandro M. Vannucchi   +15 more
doaj   +1 more source

Accuracy of B-mode ultrasonography for detecting malignancy in canine cutaneous neoplasms: preliminary results [PDF]

Pesquisa Veterinária Brasileira, 2021
: The aim of this study was to verify the applicability and accuracy of B-mode ultrasonography in detecting malignancy in dog cutaneous neoplasms. Forty-two neoplasms (12 benign and 30 malignant) of mesenchymal, round cells, epithelial and melanocytic ...
Igor C.K. da Cruz, Maria L.A. Mestieri, João P.E. Pascon, Mauren P. Emanuelli, Maria E. Trost, Etiele M. Gomes, Ingrid R.L. Machado   +6 more
doaj   +1 more source

Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells

Frontiers in Immunology, 2023
Transplantation of hematopoietic stem cells (HSCT) is a procedure commonly used in treatment of various haematological disorders which is associated with significantly improved survival rates.
Jagoda Siemaszko, Piotr Łacina, Donata Szymczak, Agnieszka Szeremet, Maciej Majcherek, Anna Czyż, Małgorzata Sobczyk-Kruszelnicka, Wojciech Fidyk, Iwona Solarska, Barbara Nasiłowska-Adamska, Patrycja Skowrońska, Maria Bieniaszewska, Agnieszka Tomaszewska, Grzegorz W. Basak, Sebastian Giebel, Tomasz Wróbel, Katarzyna Bogunia-Kubik   +16 more
doaj   +1 more source

Neutrophil-to-lymphocyte ratio is a novel predictor of venous thrombosis in polycythemia vera

Blood Cancer Journal, 2022
We investigated the neutrophil-to-lymphocyte ratio (NLR) as a predictor of thrombosis in polycythemia vera (PV). After a median follow-up of 2.51 years, of 1508 PV patients enrolled in the ECLAP study, 82 and 84 developed arterial and venous thrombosis ...
Alessandra Carobbio, Alessandro Maria Vannucchi, Valerio De Stefano, Arianna Masciulli, Paola Guglielmelli, Giuseppe Gaetano Loscocco, Francesco Ramundo, Elena Rossi, Yogendra Kanthi, Ayalew Tefferi, Tiziano Barbui   +10 more
doaj   +1 more source

BTLA Expression in CLL: Epigenetic Regulation and Impact on CLL B Cell Proliferation and Ability to IL-4 Production

Cells, 2021
In our previous study, while chronic lymphocytic leukemia (CLL) cases showed higher levels of B and T lymphocyte attenuator (BTLA) mRNA compared to controls, lower BTLA protein expression was observed in cases compared to controls.
Lidia Karabon, Anna Andrzejczak, Lidia Ciszak, Anna Tomkiewicz, Aleksandra Szteblich, Agnieszka Bojarska-Junak, Jacek Roliński, Dariusz Wołowiec, Tomasz Wróbel, Agata Kosmaczewska   +9 more
doaj   +1 more source

Mathematical methods and models for radiation carcinogenesis studies [PDF]

, 1986
Research on radiation carcinogenesis requires a twofold approach. Studies of primary molecular lesions and subsequent cytogenetic changes are essential, but they cannot at present provide numerical estimates of the risk of small doses of ionizing ...
A.M. Kellerer, Barlow, Bernoulli, Breslow, Broerse, Broerse, Chmelevsky, Chmelevsky, Chmelevsky, Groer, Hoel, Hulse, Kalbfleisch, Kaplan, Kellerer, Lafuma, Mole, National Academy of Sciences, National Research Council, Nelson, Recommendations of the International Commission on Radiological Protection, Rossi, Shellabarger, Shellabarger, Shellabarger, UNSCEAR-Report, Whittemore   +25 more
core   +1 more source

Raman spectroscopy in noninvasive optical diagnostics of skin neoplasms [PDF]

Наука и инновации в медицине, 2023
Aim to propose a schematic design of a new prototype having a potential for mass production and use in medical institutions for routine diagnostics of skin neoplasms. Material and methods.
Oleg I. Kaganov, Yuliya G. Loginova, Aleksandr A. Moryatov, Sergei V. Kozlov   +3 more
doaj   +1 more source