Results 181 to 190 of about 574,487 (311)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Myolipoma of the uterus with bizarre-nucleated cells: a case report and literature review. [PDF]

Int J Clin Exp Pathol
Zhang L, Niu C.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Tensor enhanced chest cancer classification via CNN and Vision Transformer models. [PDF]

PLoS One
Asim N, Sirshar M, Khan MZ, Ejaz S, Khalid S, Aljubayri I, Alahmadi A.   +6 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

From Gas Chromatography-Mass Spectrometry (GC-MS) to Network Pharmacology: System-Level Insights into the Multi-Target Biological Potential of <i>Flaveria trinervia</i> (Spreng.) C. Mohr. [PDF]

Curr Issues Mol Biol
Torres Flores C, Pérez-Campos E, Pérez-Campos Mayoral L, Laguna-Barrios LÁ, Méndez-Rodríguez KB, Pérez-Vázquez FJ, Pérez Campos-Mayoral E, Lastre-Domínguez CM, Jarquín González EE, Martínez Cruz M, Pina Canseco MDS, Mora Guzmán Z, López Montesinos KC, Cabrera-Fuentes HA, Hernández-Huerta MT.   +14 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Editorial: Biological and clinical implications of the mutational landscape in myeloproliferative neoplasms

Frontiers in Oncology
Giuseppe Gaetano Loscocco, Barbara Mora, Naseema Gangat   +2 more
doaj   +1 more source

Analysis of Torquetenovirus DNA levels in NSCLC patients treated with immune checkpoint inhibitors. [PDF]

PLoS One
Cinti L, Tuosto L, Roberto P, Campagna R, Rughetti A, Napoletano C, Gelibter AJ, Santini D, Antonelli G, Turriziani O.   +9 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source