Results 101 to 110 of about 24,318 (219)

Alternative MYB Promoter Activity Is a Potential Prognostic Biomarker in Head and Neck Adenoid Cystic Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Adenoid cystic carcinoma (ACC) is an aggressive therapy‐resistant head and neck cancer with a high frequency of local recurrences and distant metastases. Activation of the MYB gene, encoding an oncogenic master transcription factor, is the key genomic hallmark of ACC and a potential therapeutic target. Here, we have investigated the
Fredrik Jäwert, André Fehr, Marta Persson, Adel K. El‐Naggar, Göran Stenman, Mattias K. Andersson   +5 more
wiley   +1 more source

Clinical Outcomes of Intensity Modulated Proton Therapy for Salivary Gland Carcinoma: High Local Control and Quality of Life Preservation

Head &Neck, EarlyView.
ABSTRACT Background In recent years, particle therapy has shown promise as a local treatment for salivary gland carcinoma (SGC); however, its efficacy and safety remain unclear. This study aimed to evaluate the clinical outcomes of intensity‐modulated proton therapy (IMPT) for SGC.
Gaku Takano, Daisuke Kawakita, Hiromitsu Iwata, Yukiko Hattori, Koichiro Nakajima, Yusuke Tsuzuki, Shuou Sudo, Toshiyuki Toshito, Kensuke Hayashi, Takuma Matoba, Michi Sawabe, Kiyoshi Minohara, Sho Iwaki, Kazuyuki Nakai, Yu Iwase, Shinichi Iwasaki, Hiroyuki Ogino   +16 more
wiley   +1 more source

Reproductive tract biology: Of mice and men. [PDF]

, 2019
The study of male and female reproductive tract development requires expertise in two separate disciplines, developmental biology and endocrinology.
Baskin, Laurence S, Cao, Mei, Cunha, Gerald R, Ricke, Will A, Robboy, Stanley J, Sinclair, Adriane   +5 more
core  

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, EarlyView.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source

Urachal Villous Adenoma Coexistent With Urachal Carcinoma: A Case Report

IJU Case Reports, EarlyView.
ABSTRACT Introduction Urinary tract villous adenomas are uncommon, urachal villous adenomas being especially rare. While their malignant potential remains uncertain, villous adenomas may have malignant components. Here, we present a case of the coexistence of a urachal villous adenoma and urachal carcinoma. Case Presentation We report the case of an 86‐
Shotaro Hatano, Yousuke Shimizu, Hirotake Fujii, Koken Hayashi, Ken Maekawa, Yasuyuki Miyauchi, Takaki Sakurai, Kenji Mitsumori, Hiroyuki Onishi   +8 more
wiley   +1 more source

Skin microbiome engineering: Challenges and opportunities in skin diseases treatment

iMetaOmics, EarlyView.
The skin microbiome plays a crucial role in skin health, influencing barrier integrity, immune responses, and disease susceptibility. Various interventions can reshape the microbiome, broadly categorized into targeted and untargeted approaches. Targeted strategies, such as phage therapy, engineered bacteria, and phage lysins, selectively modulate ...
Yiang Lyu, Juntao Shen, You Che, Lei Dai
wiley   +1 more source

Organoid‐tissue extracellular vesicles

Interdisciplinary Medicine, EarlyView.
Abstract Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment.
Han Liu, Ting Cheng, Guangfeng Li, Zhidao Xia, Chenglong Wang, Ke Xu, Jiacan Su   +6 more
wiley   +1 more source

Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Madison Owens, Anita Thyagarajan, Jeffrey B. Travers, Ravi P. Sahu   +3 more
wiley   +1 more source

Fluorescence Lifetime Imaging Techniques—A Review on Principles, Applications and Clinical Relevance

Journal of Biophotonics, EarlyView.
This article gives an overview of the most frequently used fluorescence‐lifetime imaging (FLIM) techniques, their capabilities and typical applications in biology and clinical studies. ABSTRACT This article gives an overview of the most frequently used fluorescence‐lifetime imaging (FLIM) techniques, their capabilities, and typical applications ...
V. I. Shcheslavskiy, M. V. Shirmanova, K. S. Yashin, A. C. Rück, M. C. Skala, W. Becker   +5 more
wiley   +1 more source