Results 51 to 60 of about 9,604,418 (279)
Multiple primary malignant neoplasms associated with genitourinary cancer [PDF]
, 1996 当院泌尿器科で発見された尿路性器癌392例の中, 重複癌(三重癌も含む)と診断された42例について臨床的検討を行った. 1)発生頻度は重複癌9.9%, 三重癌0.7%であった.男女比は5:1であった. 2)尿路性器系重複癌の臓器別発生頻度は単発癌のそれとほぼ同じであったが, 前立腺癌にやや多い傾向がみられた. 3)他臓器系の癌の組み合わせでは, 胃癌, 膵癌など消化器系の癌の比率が高い傾向がみられた.
深貝, 隆志 +4 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Бюллетень сибирской медициныAim. To analyze the structure of deaths from sporadic metachronous primary multiple malignant neoplasms in 2017–2023 in a multidisciplinary inpatient facility.Materials and methods.
M. V. Zavyalova +9 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Thoracic Cancer, 2021 Although the number of patients diagnosed with synchronous multiple primary lung cancer is growing because of increased screening and improved imaging technology, synchronous triple primary lung cancer with different histological tumor subtypes occurring
Tsutomu Koyama +8 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Frontiers in EndocrinologyBackgroundThe incidence of thyroid cancer is on the rise worldwide, with childhood exposure to radiation being the sole acknowledged catalyst for its emergence. Nonetheless, numerous other factors that may pose risks are awaiting thorough examination and
Akram Al-Ibraheem +11 more
doaj +1 more source
Wiadomosci lekarskie (Warsaw, Poland : 1960), 1990 In the years 1980-1987 in the Department of Internal Diseases, Silesian Medical Academy in Katowice 32 patients were observed with multiple malignant neoplasms of various organs. The time from the diagnosis of the first neoplasm to the appearance of the second one was from 0 to 168 months (mean 61.8 months).
W, Poborski +3 more
openaire +1 more source