Results 91 to 100 of about 2,212,728 (310)
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Efficacy and Mechanism EvaluationBackground Merkel cell carcinoma is a rare locally invasive skin cancer of older people. Standard management for primary Merkel cell carcinoma is surgery and/or radiotherapy, with no standard of care or unity of practice, based on retrospective ...
Neil M Steven +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2018 Intra-tumor cellular heterogeneity is a major challenge in cancer therapy. Tumors are composed of multiple phenotypic subpopulations that vary in their ability to initiate metastatic tumors and in their sensitivity to chemotherapy.
Alexander E. Davies, John G. Albeck
doaj +1 more source
Fluorescence Spectroscopy of Neoplastic and Non-Neoplastic Tissues
Neoplasia, 2000 Fast and non-invasive, diagnostic techniques based on fluorescence spectroscopy have the potential to link the biochemical and morphologic properties of tissues to individual patient care. One of the most widely explored applications of fluorescence spectroscopy is the detection of endoscopically invisible, early neoplastic growth in epithelial tissue ...
openaire +3 more sources
, 2009 Neoplastic meningitis is a diffuse dissemination of tumour cells in the cerebrospinal fluid (CSF), leptomeninges, or both. It occurs in approximately 5-10% of malignant diseases, most often in breast cancer, lung cancer, melanoma, and B-cell lymphoma ...
Proemmel, Peter, Strik, Herwig Matthias
core +1 more source
FEBS Open Bio, EarlyView.Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar +11 more
wiley +1 more source
The Role of CT scan In Differentiating between Neoplastic and Benign Portal Vein Thrombosis Using Thrombus Density [PDF]
International Journal of Medical ArtsBackground: Portal vein thrombosis (PVT) is described as the presence of a clot in the portal vein lumen. It's considered as common complication of chronic liver disease and hepatocellular carcinoma (HCC).
Manal Gomaa +3 more
doaj +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Biomedical and Biotechnology Research JournalBackground: DEAD-box RNA helicases regulates RNA metabolism, therapeutic resistance, and tumor progression. Although X and Y linked DEAD box RNA helicases (DDX3X and DDX3Y) are highly conserved, their sex-associated post-transcriptional regulation in ...
Mahendran Botlagunta +2 more
doaj +1 more source