Results 91 to 100 of about 4,884,808 (294)

Unique T-Cell Populations Define Immune-Inflamed Hepatocellular CarcinomaSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: The characterization of T cells infiltrating hepatocellular carcinoma (HCC) provides information on cancer immunity and also on selection of patients with precise indication of immunotherapy.
Daniela Di Blasi, Tujana Boldanova, Lucia Mori, Luigi Terracciano, Markus H. Heim, Gennaro De Libero   +5 more
doaj   +1 more source

Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells [PDF]

, 2009
Background Transplantation of vasculogenic progenitor cells (VPC) improves neovascularization after ischemia. However, patients with type 2 diabetes mellitus show a reduced VPC number and impaired functional activity. Previously, we demonstrated that p38
Aicher Alexandra, Chen Linping, Seeger Florian Hartmut, Altschmied Joachim, Haendeler Judith, Alexandra Aicher, Aicher, Alexandra, Judith Haendeler, Seeger, Florian Hartmut, Chen, Linping, Haendeler, Judith, Florian Hartmut Seeger, Linping Chen, Joachim Altschmied, Spyridopoulos Ioakim, Spyridopoulos, Ioakim, Altschmied, Joachim, Ioakim Spyridopoulos   +17 more
core   +2 more sources

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Paradigm shift in dendritic cell-based immunotherapy: from in vitro generated monocyte-derived DCs to naturally circulating DC subsets

Frontiers in Immunology, 2014
Dendritic cell-based immunotherapy employs the patients’ immune system to fight neoplastic lesions spread over the entire body. This makes it an important therapy option for patients suffering from metastatic melanoma, which is often resistant to ...
Florian eWimmers, Gerty eSchreibelt, Annette E. Sköld, Carl G. Figdor, I. Jolanda M. ede Vries, I. Jolanda M. ede Vries   +5 more
doaj   +1 more source

Monitoring Circulating CD207+CD1a+ Cells in Langerhans Cell Histiocytosis and Clinical Implications

, 2022
Langerhans cell histiocytosis (LCH) is a disorder characterized by an abnormal accumulation of CD207+ and CD1a+ cells in almost any tissue. Currently, there is a lack of prognostic markers to follow up patients and track disease reactivation or treatment
Nowak, Wanda, Carrera Silva, Eugenio Antonio, Fortunati, Daniela, Rosso, Diego, Olexen, Cinthia Mariel, Errasti, Andrea Emilse   +5 more
core   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Pivotal Role of STAT3 in Shaping Glioblastoma Immune Microenvironment

Cells, 2019
Glioblastoma belongs to the most malignant intracranial tumors characterized by indispensable growth and aggressiveness that highly associates with dismal prognosis and therapy resistance.
Christina Piperi, Kostas A. Papavassiliou, Athanasios G. Papavassiliou   +2 more
doaj   +1 more source

Detection of circulating fetal cells utilizing automated microscopy: potential for noninvasive prenatal diagnosis of chromosomal aneuploidies

, 2008
Objective As fetal cells can be indisputably identified through detection of Y FISH signals, we utilized all automated microscopy system developed to identify and enumerate cells bearing X and Y FISH signals.
Tsipouras, P, Seppo, A, Kim, YM, Nicolaides, Kypros H., Ichetovkin, Ilia, Evan, Mark I., Tafas, R, Antsaklis, Aristeidis, Ichetovkin, I, Nicolaides, KH, Kim, Youngmin, Tafas, Rriantafyllos, Antsaklis, A, Frisova, Veronika, Frisova, V, Evan, MI, Seppo, Antti, Kilpatrick, MW, Kilpatrick, Michael W., Tsipouras, Petros   +19 more
core   +1 more source

SDF1 Gene Variation Is Associated with Circulating SDF1 alpha Level and Endothelial Progenitor Cell Number-The Bruneck Study [PDF]

, 2008
BACKGROUND: Stromal cell-derived factor-1 (SDF1) and its receptor CXC chemokine receptor 4 (CXCR4) play a critical role in progenitor cell homing, mobilization and differentiation.
Marjan Jahangiri, Kiechl, Stefan, Mayr, A, Willeit, J, Qingzhong Xiao, Friedrich Oberhollenzer, Xu Qingbo, Jahangiri, M, Ye Shu, Oberhollenzer Friedrich, Jahangiri, Marjan, Willeit Johann, Mayr, Agnes, Oberhollenzer, F, Mayr Agnes, Willeit, Johann, Ye, Shu, Xiao, Q, Ye, S, Kiechl, S, Kiechl Stefan, Xu, Q, Jahangiri Marjan, Stefan Kiechl, Qingbo Xu, Xiao Qingzhong, Johann Willeit, Oberhollenzer, Friedrich, Xu, Qingbo, Shu Ye, Agnes Mayr, Xiao, Qingzhong   +31 more
core   +2 more sources

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source