Results 71 to 80 of about 247,318 (300)

Case report: Senescence as mechanism of resistance to Pembrolizumab in a Lymphoma patient who failed CD19-Targeted CAR-T cell therapy

Frontiers in Immunology, 2022
BackgroundT cells engineered to target CD19 antigen on neoplastic B cells represent the most striking example of CAR-T cell therapy. The success rate of this therapy is affected by several limitations: target antigen loss, and/or acquisition of a ...
Serena De Matteis, Beatrice Casadei, Beatrice Casadei, Ginevra Lolli, Ginevra Lolli, Michele Dicataldo, Michele Dicataldo, Francesco Barbato, Francesco Barbato, Elisa Dan, Andrea Paccagnella, Barbara Sinigaglia, Clara Bertuzzi, Annalisa Arcari, Luca Zazzeroni, Patrizia Bernuzzi, Noemi Laprovitera, Gianluca Storci, Salvatore Nicola Bertuccio, Manuela Ferracin, Massimiliano Bonafè, Pier Luigi Zinzani, Pier Luigi Zinzani, Francesca Bonifazi   +23 more
doaj   +1 more source

Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall [PDF]

, 2018
Benign TdT-positive cells have been documented in a variety of non-hematopoietic tissues. Scant data are however available on their presence in non-neoplastic lymph nodes.
AGOSTINELLI, CLAUDIO, Bertuzzi, Clara, BRIGNOLA, STEFANO, Pillon, Marta, Pizzi, Marco, Righi, Simona, Rugge, Massimo, Sabattini, Elena, Semenzato, Gianpietro   +8 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Chemotherapy treatment of multiple myeloma patients increases circulating levels of endothelial microvesicles [PDF]

, 2016
Correspondenc
Adesanya, M. Adeola, Gardiner, Eric, Hall, Jessica, Madden, Leigh, Maraveyas, Anthony, Sayala, Haz   +5 more
core   +1 more source

Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries

Journal of the Pakistan Medical Association
Approaches to brain tumour diagnosis and detecting recurrence after treatment are costly and significantly invasive. Developing peripheral-sample liquid biopsy tools is the key to enhancing our ability to prognosticate brain tumour subtypes and ...
Mohammad Hamza Bajwa, Muhammad Awais Khan, Faiza Urooj, Muhammad Usman Khalid, Syed Ather Enam, Hafiza Fatima Aziz, Kaynat Siddiqui, Muhammad Ehsan Bari, Nouman Mughal   +8 more
doaj   +1 more source

Paradigm shift in dendritic cell-based immunotherapy: from in vitro generated monocyte-derived DCs to naturally circulating DC subsets

Frontiers in Immunology, 2014
Dendritic cell-based immunotherapy employs the patients’ immune system to fight neoplastic lesions spread over the entire body. This makes it an important therapy option for patients suffering from metastatic melanoma, which is often resistant to ...
Florian eWimmers, Gerty eSchreibelt, Annette E. Sköld, Carl G. Figdor, I. Jolanda M. ede Vries, I. Jolanda M. ede Vries   +5 more
doaj   +1 more source

Unique T-Cell Populations Define Immune-Inflamed Hepatocellular CarcinomaSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: The characterization of T cells infiltrating hepatocellular carcinoma (HCC) provides information on cancer immunity and also on selection of patients with precise indication of immunotherapy.
Daniela Di Blasi, Tujana Boldanova, Lucia Mori, Luigi Terracciano, Markus H. Heim, Gennaro De Libero   +5 more
doaj   +1 more source

Evaluation of the activity of the immune system and age-related tissue markers in Turquoise killifish \ud (Nothobranchius furzeri, Jubb 1971) \ud and their role in cell ageing\ud [PDF]

, 2010
Currently the Turquoise Killifish is considered the best animal model suitable for aging research. \ud This annual fish, from south east Africa, shows an exceptionally adaptive behaviour to dry periods: indeed, due to this extreme environmental ...
Di Cicco, Emiliano, Rossi, Giacomo
core  

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival [PDF]

, 2015
Leukemic cells from Chronic Lymphocytic Leukemia (CLL) patients interact with stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) represent the main population in CLL marrow stroma, which may play a key role for disease ...
Ave, Elisa, Castelli, Monica, Chiodin, Giorgia, Facco, Monica, Frezzato, Federica, Gattazzo, Cristina, Giorgi, CARLO ALBERTO, Lessi, Federica, Martini, Veronica, Piazza, Francesco, Semenzato, GIANPIETRO CARLO, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea, Zambello, Renato   +15 more
core   +2 more sources