Results 81 to 90 of about 247,318 (300)
Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model
Advanced Science, EarlyView.A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen +15 more
wiley +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Pivotal Role of STAT3 in Shaping Glioblastoma Immune Microenvironment
Cells, 2019 Glioblastoma belongs to the most malignant intracranial tumors characterized by indispensable growth and aggressiveness that highly associates with dismal prognosis and therapy resistance.
Christina Piperi +2 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang +8 more
wiley +1 more source
Circulating extracellular vesicle-microRNAs (EV-miRNAs) in leukemias and related disorders
Frontiers in MedicineExtracellular vesicles (EVs) are nanoparticles released from all cell types and function as a biological tool for cell-to-cell communication or organs located even in remote parts.
Tsukuru Umemura +3 more
doaj +1 more source
Loss of the candidate tumor suppressor ZEB1 (TCF8, ZFHX1A) in Sézary syndrome [PDF]
, 2018 Cutaneous T-cell lymphoma is a group of incurable extranodal non-Hodgkin lymphomas that develop from the skin-homing CD4+ T cell. Mycosis fungoides and Sézary syndrome are the most common histological subtypes.
Benucci, Roberto +9 more
core +2 more sources
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
Autopsy and Case Reports, 2021 In adults, B-lymphocytes comprise approximately 10% of circulating lymphocytes. The majority of peripheral B cells are B2 cells (“Mature” B-cells), which function as part of the humoral adaptive immune system. B1 cells (“Innate-like” B cells) are another
Amir Qorbani +2 more
doaj
Physiopathological Implications of 7TM Receptors [PDF]
, 2010 Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core +2 more sources
Wearable Battery‐Free Electrotherapy of Smartsensors for Wound Healthcare
Advanced Science, EarlyView.Herein, we propose a simple strategy for integrating battery‐free electrotherapy wound dressings with wound sensors. Solid‐state supercapacitors constructed by PMAB with cross‐linked interpenetrating network provide energy for electrotherapy. Meanwhile, excellent mechanical sensing performance of wound dressing was used for wound assessment.
Wenrui Zhang +9 more
wiley +1 more source