Results 81 to 90 of about 508,130 (309)

CXCL12 loaded-dermal filler captures CXCR4 expressing melanoma circulating tumor cells

Cell Death and Disease, 2019
Development of distant metastasis relies on interactions between cancer and stromal cells. CXCL12, also known as stromal-derived factor 1α (SDF-1α), is a major chemokine constitutively secreted in bone marrow, lymph nodes, liver and lung, playing a ...
C. Ieranò, C. D’Alterio, Simona Giarra, M. Napolitano, Giuseppina Rea, L. Portella, A. Santagata, A. Trotta, A. Barbieri, Virginia Campani, A. Luciano, C. Arra, A. Anniciello, G. Botti, L. Mayol, G. De Rosa, R. Pacelli, S. Scala   +17 more
semanticscholar   +1 more source

A Compact Spin‐Coated Graphene UWB Antenna for Breast Tumor Detection

Advanced Engineering Materials, EarlyView.
A compact, spin‐coated graphene ultra‐wideband patch antenna designed for breast tumor detection, capable of distinguishing between malignant and benign tumors. This innovative antenna can serve as an effective initial screening tool, particularly in resource‐limited settings such as rural areas, where access to advanced medical equipment like MRI and ...
Raja Rashidul Hasan, Shuvra Saha, Sumit Hassan Eshan, Rinku Basak, Md. Nahian Al Subri Ivan, Ahmed Murtuza Saleque, Raja Tariqul Hasan Tusher, Sadia Zabin, Md. Abdur Rahman, Yuen Hong Tsang   +9 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Differentiation of CTCs from circulating non-neoplastic cells in DVB and PB from CRC patients.

, 2019
(A) Leukocyte cluster stained for Pap/CD45 and a macrophage stained for Pap/CD68. (B) Circulating megakaryocytes in PB stained for Pap/CD61, showing multinucleated giant cell morphology.
Yasuhiro Shimizu (2213161), Mayumi Yoshimura (6407297), Yasuhiro Kodera (3441125), Kentaro Wajima (6407306), Taihei Oshiro (6407300), Seichin Kinuta (521984), Masayuki Tsutsuyama (6407294), Yoshiyuki Ichinosawa (521983), Seiji Ito (229086), Yasufumi Sakakibara (521211), Hayao Nakanishi (521985), Koji Komori (6407303), Takashi Kinoshita (440727), Yasushi Yatabe (245392)   +13 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Acute aleukemic mast cell leukemia: Report of a case and review of the literature

Leukemia Research Reports, 2020
Mast Cell Leukemia (MCL) is the rarest form of systemic mastocytosis, a rare group of neoplastic disease that result from clonal proliferation of mast cells and their accumulation in one or more organ systems.
Gian M. Galura, Sundar V. Cherukuri, Nawar Hakim, Sumit Gaur, Attilio Orazi   +4 more
doaj   +1 more source

Altered membrane lipid composition and functional parameters of circulating cells in cockles (Cerastoderma edule) affected by disseminated neoplasia

, 2013
International audienceMembrane lipid composition and morpho-functional parameters were investigated in circulating cells of the edible cockle (Cerastoderma edule) affected by disseminated neoplasia (neoplastic cells) and compared to those from healthy ...
Marty, Yanic, Le Grand, Fabienne, Le Goïc, Nelly, Soudant, Philippe, Kraffe, Edouard   +4 more
core   +1 more source

Circulating Lymphangioleiomyomatosis Tumor Cells With Loss of Heterozygosity in the TSC2 Gene Show Increased Aldehyde Dehydrogenase Activity.

Chest, 2019
BACKGROUND Lymphangioleiomyomatosis (LAM) is a destructive metastasizing neoplasm of the lung characterized by proliferation of LAM cells in specialized lung nodules.
G. Pacheco–Rodriguez, W. Steagall, L. Samsel, Pradeep K. Dagur, J. McCoy, I. Tunc, M. Pirooznia, Ji‐an Wang, T. Darling, J. Moss   +9 more
semanticscholar   +1 more source

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Liquid Biopsy in Clinical Management of Breast, Lung, and Colorectal Cancer

Frontiers in Medicine, 2018
Examination of tumor molecular characteristics by liquid biopsy is likely to greatly influence personalized cancer patient management. Analysis of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and tumor-derived exosomes, all collectively
Ivana Bratić Hench, Jürgen Hench, Markus Tolnay   +2 more
doaj   +1 more source