Results 131 to 140 of about 508,130 (309)

Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy

Frontiers in Oncology
Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and extracellular vehicles (EVs) have received significant attention in recent times as emerging biomarkers and subjects of transformational studies.
Xiaoling Wang, Xiaoling Wang, Lijuan Wang, Lijuan Wang, Haihong Lin, Haihong Lin, Yifan Zhu, Yifan Zhu, Defa Huang, Mi Lai, Xuxiang Xi, Junyun Huang, Junyun Huang, Wenjuan Zhang, Wenjuan Zhang, Tianyu Zhong, Tianyu Zhong   +16 more
doaj   +1 more source

Targeting intratumoral B cells with rituximab in addition to CHOP in angioimmunoblastic T-cell lymphoma. A clinicobiological study of the GELA

Haematologica, 2012
Background In angioimmunoblastic T-cell lymphoma, symptoms linked to B-lymphocyte activation are common, and variable numbers of CD20+ large B-blasts, often infected by Epstein-Barr virus, are found in tumor tissues.
Marie-Hélène Delfau-Larue, Laurence de Leval, Bertrand Joly, Anne Plonquet, Dominique Challine, Marie Parrens, Alain Delmer, Gilles Salles, Franck Morschhauser, Richard Delarue, Pauline Brice, Reda Bouabdallah, Olivier Casasnovas, Hervé Tilly, Philippe Gaulard, Corinne Haioun   +15 more
doaj   +1 more source

Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: Cytoplasmic clusterin localization in adenohypophysis is related to aging

, 2008
Clusterin is a circulating multifunctional glycoprotein produced in several kinds of epithelial and neuronal cells. Clusterin is upregulated during different physiological and pathological states, such as senescence, type-2 diabetes mellitus, Alzheimer ...
Çomunoğlu, Nil, Ekici, Asiye Isin Dogan   +1 more
core   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

T- and NK-cell populations with regulatory phenotype and markers of apoptosis in circulating lymphocytes of patients with CIN3 or microcarcinoma of the cervix: evidence for potential mechanisms of immune suppression

Infectious Agents and Cancer, 2017
Background Processes and mechanisms responsible for systemic immune suppression in early-stage cervical cancer remain substantially underinvestigated.
Olga V. Kurmyshkina, Pavel I. Kovchur, Ludmila V. Schegoleva, Tatyana O. Volkova   +3 more
doaj   +1 more source

Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands [PDF]

in chronic lymphocytic leukemia (CLL), survival of neoplastic cells depends on microenvironmental signals at lymphoid sites where the crosstalk between the integrin VLA-4 (CD49d/CD29), expressed in ~40% of CLL, and the B-cell receptor (BCR) occurs. Here,
Del Principe, Maria Ilaria, Ianna, Giulia, Zucchetto, Antonella, Rossi, Francesca Maria, Gaidano, Gianluca, Jumaa, Hassan, Gattei, Valter, Tissino, Erika, Nicolò, Antonella, D'Arena, Giovanni, Rossi, Davide, Del Poeta, Giovanni, Palumbo, Giuseppe A., Hartmann, Tanja Nicole, Capasso, Guido, Maity, Palash C, Laurenti, Luca, Laureana, Roberta, Nanni, Paola, Moia, Riccardo, Cattarossi, Ilaria, Zaja, Francesco, Pozzo, Federico, Härzschel, Andrea, Datta, Moumita, Martino, Enrica Antonia, Gentile, Massimo, Chiarenza, Annalisa, Gaglio, Annalisa, Olivieri, Jacopo, Zimbo, Anna Maria, Palumbo, Giuseppe A, PALUMBO, Giuseppe Alberto Maria, Zaina, Eva, Forestieri, Gabriela, Bomben, Riccardo, Maity, Palash C., Bittolo, Tamara   +37 more
core   +2 more sources

Intratumor heterogeneity in epithelial cancer: Assessment in cell line models and circulating tumor cells

Makara Journal of Health Research, 2019
Background: CTCs are present only in small numbers in patients' blood. This study aimed to establish a protocol for enumeration and phenotypic characterization of circulating tumor cells (CTCs) by ImageStreamX MK II (AMNIS) imaging flow cytometry and to ...
Wimba W. Dinutanayo, Ingeborg T. Keilholz, Diana Braunholz   +2 more
doaj   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Circulating Cell-Free DNA in Hepatocellular Carcinoma: Current Insights and Outlook

Frontiers in Medicine, 2018
Over the past decade, the advancements in massively parallel sequencing have provided a new paradigm in biomedical research to uncover the genetic basis of human diseases.
Charlotte K. Y. Ng, Charlotte K. Y. Ng, Giovan Giuseppe Di Costanzo, Luigi M. Terracciano, Salvatore Piscuoglio   +4 more
doaj   +1 more source