Results 121 to 130 of about 389,847 (293)

Expression patterns and clinical significance of the potential cancer stem cell markers OCT4 and NANOG in colorectal cancer patients

Molecular & Cellular Oncology, 2020
Colorectal cancer (CRC) is one of the most important malignancies and causes of cancer-related deaths worldwide. Cancer stem cell markers identification could be helpful to acquire important prognostic information and develop new treatment regimens. This
Raheleh Roudi, Mahboubeh Barodabi, Zahra Madjd, Giandomenico Roviello, Silvia Paola Corona, Mahshid Panahi   +5 more
doaj   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Development of an in vitro model for investigating the properties of human prostate epithelial cells and prostatic carcinoma cells

, 2009
Prostate cell lines were derived from two regions of prostate tissue from the same patient. The objective was to produce cell lines (as a useful in vitro model) from these two different regions which exhibit different properties for carcinoma development.
Weaver, Jennifer
core  

Mutations in Bone Marrow-Derived Stromal Stem Cells Unmask Latent Malignancy

, 2010
Neoplastic epithelia may remain dormant and clinically unapparent in human patients for decades. Multiple risk factors including mutations in tumor cells or the stromal cells may affect the switch from dormancy to malignancy.
Christine Hewes, Hanchen Li, Houghton, JeanMarie, Christie L. Taylor, JeanMarie Houghton, Bowen, Glennice, Cerny, Jan, Rao, Varada P., Jian Hua Liu, Theofilos Poutahidis, Stephen Lyle, Jan Cerny, Liu, Yingwang, Nathan Moore, Kurt-Jones, Evelyn A., Anna Cerny, Fan, Xueli, Lyle, Stephen, Xueli Fan, Jackson, Erin A., Glennice Bowen, Li, Hanchen, Hewes, Christine M., Poutahidis, Theofilos, Moore, Nathan, Varada P. Rao, Erin A. Jackson, Taylor, Christie L., Liu, Jian Hua, Cerny, Anna, Erdman, Susan E., Susan E. Erdman, Yingwang Liu, Evelyn A. Kurt-Jones   +33 more
core   +1 more source

A modified method by differential adhesion for enrichment of bladder cancer stem cells

International Brazilian Journal of Urology
Purpose: In a previous study the vaccine was effective against bladder cancer in a mouse model. However, a small portion of tumors regrew because the vaccine could not eliminate bladder cancer stem cells (CSCs). In this study, we showed a modified method
Yong-tong Zhu, Shi-yu Pang, Yang Luo, Wei Chen, Ji-ming Bao, Wan-long Tan   +5 more
doaj   +1 more source

Establishment of a xenograft model of human myelodysplastic syndromes

Haematologica, 2011
Background To understand how myelodysplastic syndrome cells evolve from normal stem cells and gain competitive advantages over normal hematopoiesis, we established a murine xenograft model harboring bone marrow cells from patients with myelodysplastic ...
Yukari Muguruma, Hiromichi Matsushita, Takashi Yahata, Shizu Yumino, Yumiko Tanaka, Hayato Miyachi, Yoshiaki Ogawa, Hiroshi Kawada, Mamoru Ito, Kiyoshi Ando   +9 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Thoughts about cancer stem cells in solid tumors [PDF]

, 2012
Cancer chemotherapy efficacy is frequently impaired by either intrinsic or acquired tumor resistance. A fundamental problem in cancer research is identifying the cell type that is capable of sustaining neoplastic growth and its origin from normal tissue ...
C.A. La Porta
core   +1 more source

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, EarlyView.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Molecular and cellular pathogenesis of melanoma initiation and progression

, 2013
Melanoma is a malignant tumour of melanocytes, which can spread to other organs of the body resulting in severe and/or lethal malignancies. Melanocytes are pigment producing cells found in deep layer of the epidermis and are originated from melanocytes ...
Regad, T
core   +1 more source