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Neoplastic stem cells: A novel therapeutic target in clinical oncology [PDF]
Cancer, 2006 AbstractCancer is among the leading causes of morbidity and mortality in the Western world. Despite recent advances, most therapeutic approaches fail to eradicate the entire neoplastic clone. The remaining cells often develop metastasis and/or recurrences and therefore may represent attractive targets of therapy.
Axel Schulenburg +2 more
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Normal and neoplastic urothelial stem cells: getting to the root of the problem [PDF]
Nature Reviews Urology, 2012 Most epithelial tissues contain self-renewing stem cells that mature into downstream progenies with increasingly limited differentiation potential. It is not surprising that cancers arising from such hierarchically organized epithelial tissues retain features of cellular differentiation. Accumulating evidence suggests that the urothelium of the urinary
Antonina Kurtova +2 more
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Neoplastic stem cells: Current concepts and clinical perspectives
Critical Reviews in Oncology/Hematology, 2010Neoplastic stem cells have initially been characterized in myeloid leukemias where NOD/SCID mouse-repopulating progenitors supposedly reside within a CD34+/Lin- subset of the malignant clone. These progenitors are considered to be self-renewing cells responsible for the in vivo long-term growth of neoplastic cells in leukemic patients. Therefore, these
Harald Herrmann +2 more
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Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation [PDF]
Nature, 2008 Cancer stem cells are remarkably similar to normal stem cells: both self-renew, are multipotent and express common surface markers, for example, prominin 1 (PROM1, also called CD133). What remains unclear is whether cancer stem cells are the direct progeny of mutated stem cells or more mature cells that reacquire stem cell properties during tumour ...
Liqin Zhu, Paul Gibson, Yiai Tong
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Leukemia and Lymphoma, 2008
In chronic myeloid leukemia (CML), neoplastic stem cells and/or their subclones exhibit resistance against BCR/ABL tyrosine kinase inhibitors (TKIs). Therefore, residual CML stem cells (subclones) in TKI-treated patients are a logical target of therapy, and their elimination is considered a major aim and clue in the development of curative treatment ...
Peter Valent, Michael Deininger
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In chronic myeloid leukemia (CML), neoplastic stem cells and/or their subclones exhibit resistance against BCR/ABL tyrosine kinase inhibitors (TKIs). Therefore, residual CML stem cells (subclones) in TKI-treated patients are a logical target of therapy, and their elimination is considered a major aim and clue in the development of curative treatment ...
Peter Valent, Michael Deininger
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Normal and neoplastic stem cells
Experimental Hematology, 2015Stem cells are cells that at the single cell level both self-renew and give rise to differentiated progeny. Self renewal is the property that distinguishes stem cells and progenitors, and in the blood-forming system explains why haematopoietic stem cells (HSCs), not progenitors, are the only cells capable of providing rapid and sustained regeneration ...
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Normal and Neoplastic Stem Cells
2012Recent evidence has revealed the presence of neoplastic stem cells in multiple cancers, both solid and hematological. In this chapter, the similarities and differences between normal and neoplastic stem cells are reviewed, and the basic stem cell definition, function and regulatory pathways in both types of stem cell are addressed, using the ...
Axel Schulenburg, Brigitte Marian
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Characterization of human embryonic stem cells with features of neoplastic progression
Nature Biotechnology, 2009Cultured human embryonic stem (hES) cells can acquire genetic and epigenetic changes that make them vulnerable to transformation. As hES cells with cancer-cell characteristics share properties with normal hES cells, such as self-renewal, teratoma formation and the expression of pluripotency markers, they may be misconstrued as superior hES cells with ...
Werbowetski-Ogilvie, Tamara +15 more
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Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche [PDF]
Cancer Cell, 2015 The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E ...
Yoku Hayakawa +2 more
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Neoplastic Stem Cells in Cutaneous Lymphomas
Archives of Dermatology, 2004Objective: To investigate the prognostic value of initial characteristics including blood eosinophilia in patients with primary cutaneous T-cell lymphoma. Design: A retrospective inception cohort, patients included from date of diagnosis (1982-1998). Setting: Two dermatology departments of a university hospital.
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