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Linking EMT programmes to normal and neoplastic epithelial stem cells
Nature Reviews Cancer, 2021Epithelial stem cells serve critical physiological functions in the generation, maintenance and repair of diverse tissues through their ability to self-renew and spawn more specialized, differentiated cell types. In an analogous fashion, cancer stem cells have been proposed to fuel the growth, progression and recurrence of many carcinomas.
Arthur W. Lambert, Robert A. Weinberg
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Digestive Diseases and Sciences, 2020
There is little known about stem cells in human non-neoplastic and neoplastic esophageal epithelia. We have demonstrated expression of linker threonine-phosphorylated Smad2/3 (pSmad2/3L-Thr), suggesting presence of stem-like cells in mouse esophageal epithelium, and identified presence of pSmad2/3L-Thr-positive cells that might function as cancer stem ...
Shunsuke Horitani +10 more
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There is little known about stem cells in human non-neoplastic and neoplastic esophageal epithelia. We have demonstrated expression of linker threonine-phosphorylated Smad2/3 (pSmad2/3L-Thr), suggesting presence of stem-like cells in mouse esophageal epithelium, and identified presence of pSmad2/3L-Thr-positive cells that might function as cancer stem ...
Shunsuke Horitani +10 more
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Neoplastic stem cells: Current concepts and clinical perspectives
Critical Reviews in Oncology/Hematology, 2010Neoplastic stem cells have initially been characterized in myeloid leukemias where NOD/SCID mouse-repopulating progenitors supposedly reside within a CD34+/Lin- subset of the malignant clone. These progenitors are considered to be self-renewing cells responsible for the in vivo long-term growth of neoplastic cells in leukemic patients. Therefore, these
Axel, Schulenburg +14 more
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Normal and neoplastic stem cells
Experimental Hematology, 2015Stem cells are cells that at the single cell level both self-renew and give rise to differentiated progeny. Self renewal is the property that distinguishes stem cells and progenitors, and in the blood-forming system explains why haematopoietic stem cells (HSCs), not progenitors, are the only cells capable of providing rapid and sustained regeneration ...
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Normal and Neoplastic Stem Cells
2012Recent evidence has revealed the presence of neoplastic stem cells in multiple cancers, both solid and hematological. In this chapter, the similarities and differences between normal and neoplastic stem cells are reviewed, and the basic stem cell definition, function and regulatory pathways in both types of stem cell are addressed, using the ...
Axel Schulenburg, Brigitte Marian
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Potential Non-neoplastic Applications for Polyphenols in Stem Cell Utilization
Current Drug Targets, 2019While polyphenols may have important effects on pluripotential stem cells that make them noteworthy as potential antineoplastic agents, their action on stem cells may portend other health benefits, such as treatments for cardiovascular and neurocognitive disorders.
E Paul, Cherniack +2 more
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The Biology of Normal and Neoplastic Stem Cells in CML
Leukemia & Lymphoma, 1993Chronic myeloid leukemia (CML) has long served as a prototype malignancy for basic as well as clinical studies aimed at developing curative cancer treatment protocols. Well established features of chronic phase CML are its origin in a pluripotent stem cell, a now well defined molecular genetic basis involving the creation of a BCR-ABL fusion gene and ...
C, Eaves +4 more
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Neoplastic Stem Cells in Cutaneous Lymphomas
Archives of Dermatology, 2004Objective: To investigate the prognostic value of initial characteristics including blood eosinophilia in patients with primary cutaneous T-cell lymphoma. Design: A retrospective inception cohort, patients included from date of diagnosis (1982-1998). Setting: Two dermatology departments of a university hospital.
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Leukemia & Lymphoma, 2008
In chronic myeloid leukemia (CML), neoplastic stem cells and/or their subclones exhibit resistance against BCR/ABL tyrosine kinase inhibitors (TKIs). Therefore, residual CML stem cells (subclones) in TKI-treated patients are a logical target of therapy, and their elimination is considered a major aim and clue in the development of curative treatment ...
Peter, Valent, Michael, Deininger
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In chronic myeloid leukemia (CML), neoplastic stem cells and/or their subclones exhibit resistance against BCR/ABL tyrosine kinase inhibitors (TKIs). Therefore, residual CML stem cells (subclones) in TKI-treated patients are a logical target of therapy, and their elimination is considered a major aim and clue in the development of curative treatment ...
Peter, Valent, Michael, Deininger
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Identification of a Neoplastic Stem Cell in Human Mast Cell Leukemia
Blood, 2014Abstract Leukemic stem cells (LSCs) have recently been identified as an important target of therapy in various human leukemias and related blood cell disorders. Systemic mastocytosis (SM) is a rare hematologic neoplasm characterized by abnormal growth and accumulation of mast cells (MCs) in various organ systems, including the bone ...
Gregor Eisenwort +13 more
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