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Potential Non-neoplastic Applications for Polyphenols in Stem Cell Utilization
Current Drug Targets, 2019While polyphenols may have important effects on pluripotential stem cells that make them noteworthy as potential antineoplastic agents, their action on stem cells may portend other health benefits, such as treatments for cardiovascular and neurocognitive disorders.
E Paul, Cherniack +2 more
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Prostate, 2009 Background: According to the cancer stem cell hypothesis, tumor growth is sustained by a subpopulation of cancer stem/progenitor-like cells. Self-renewal and high clonogenic potential are characteristics shared by normal stem and neoplastic stem ...
Antoinette Wetterwald +2 more
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Identification of a Neoplastic Stem Cell in Human Mast Cell Leukemia
Blood, 2014Abstract Leukemic stem cells (LSCs) have recently been identified as an important target of therapy in various human leukemias and related blood cell disorders. Systemic mastocytosis (SM) is a rare hematologic neoplasm characterized by abnormal growth and accumulation of mast cells (MCs) in various organ systems, including the bone ...
Gregor Eisenwort +13 more
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Variable expression of features of normal and neoplastic stem cells in patients with thrombocytosis
British Journal of Haematology, 1992Summary Essential thrombocytosis (ET) is currently diagnosed by histopathologic assessment of the marrow after exclusion of a secondary cause or another myeloproliferative disorder. To evaluate the potential of more direct diagnostic methods, we compared the frequency and association of several abnormal features characteristic of neoplastic precursors ...
A G, Turhan +4 more
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Cancer, Stem Cells and the Neoplastic Niche
2009Conventionally, cancer is treated as a homogenous mass of highly proliferative cells, with therapeutics designed to destroy rapidly dividing cells. However, not only are cancers heterogeneous, but also small subsets are endowed with the ability to initiate cancer formation and metastasis.
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Stem Cells, Nonproliferating Cells, and Their Kinetics in Normal and Neoplastic Tissues
1977At this time of increased efforts and promising results in the therapy of malignant neoplasias, it seems appropriate to review critically some principal aspects of Cell. and tissue kinetics as they relate to stem cells, to nonproliferating cells, and to Cell. recruitment into the mitotic cycle.
Milan Potmesil +2 more
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Ultrastructural Pathology, 2010
Two unique, formerly unrecorded sellar neoplasms were observed in two women of 60 and 63 years of age. One lesion consisted of small epithelial cells and the other was a large-cell oncocytic tumor, yet they had the same simple cytoplasmic organization with dominance of polyribosomes and a sprinkle of glycogen. Striking markers shared by the neoplasms: (
Eva, Horvath +3 more
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Two unique, formerly unrecorded sellar neoplasms were observed in two women of 60 and 63 years of age. One lesion consisted of small epithelial cells and the other was a large-cell oncocytic tumor, yet they had the same simple cytoplasmic organization with dominance of polyribosomes and a sprinkle of glycogen. Striking markers shared by the neoplasms: (
Eva, Horvath +3 more
openaire +2 more sources
Abstract SY08-02: Normal and neoplastic stem cells
Cancer Research, 2016Abstract The transition from single cell species to multicellular organisms led to organ and tissue development. The development and maintenance of organs/tissues in multicellular organisms has resulted in the emergence of specialized cells that self-renew as well as differentiate; these rare cells are stem cells.
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Izvestiia Akademii nauk. Seriia biologicheskaia, 2005
Certain differentiation-specific antigenic determinants are characteristic of pancreatic cells at each stage of embryonic development. Using immunohistochemical markers, we have demonstrated that the cells of several pancreatic tumors express some fetal proteins characteristic of embryonic cells of the pancreas.
L E, Gurevich +2 more
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Certain differentiation-specific antigenic determinants are characteristic of pancreatic cells at each stage of embryonic development. Using immunohistochemical markers, we have demonstrated that the cells of several pancreatic tumors express some fetal proteins characteristic of embryonic cells of the pancreas.
L E, Gurevich +2 more
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Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity
Nature Reviews Cancer, 2022Ryan C Gimple +2 more
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