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Stem cells and ageing in the blood: an interview with Margaret (Peggy) Goodell.

Dis Model Mech
Goodell MP.
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Linking EMT programmes to normal and neoplastic epithelial stem cells

Nature Reviews Cancer, 2021
Epithelial stem cells serve critical physiological functions in the generation, maintenance and repair of diverse tissues through their ability to self-renew and spawn more specialized, differentiated cell types. In an analogous fashion, cancer stem cells have been proposed to fuel the growth, progression and recurrence of many carcinomas.
Arthur W. Lambert, Robert A. Weinberg
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Specific Smad2/3 Linker Phosphorylation Indicates Esophageal Non-neoplastic and Neoplastic Stem-Like Cells and Neoplastic Development

Digestive Diseases and Sciences, 2020
There is little known about stem cells in human non-neoplastic and neoplastic esophageal epithelia. We have demonstrated expression of linker threonine-phosphorylated Smad2/3 (pSmad2/3L-Thr), suggesting presence of stem-like cells in mouse esophageal epithelium, and identified presence of pSmad2/3L-Thr-positive cells that might function as cancer stem ...
Shunsuke Horitani, Toshiro Fukui, Yuji Tanimura, Yasushi Matsumoto, Sachi Miyamoto, Toshihiro Tanaka, Takashi Tomiyama, Tsukasa Ikeura, Yugo Ando, Akiyoshi Nishio, Kazuichi Okazaki   +10 more
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Neoplastic stem cells: Current concepts and clinical perspectives

Critical Reviews in Oncology/Hematology, 2010
Neoplastic stem cells have initially been characterized in myeloid leukemias where NOD/SCID mouse-repopulating progenitors supposedly reside within a CD34+/Lin- subset of the malignant clone. These progenitors are considered to be self-renewing cells responsible for the in vivo long-term growth of neoplastic cells in leukemic patients. Therefore, these
Axel, Schulenburg, Kira, Brämswig, Harald, Herrmann, Heidrun, Karlic, Irina, Mirkina, Rainer, Hubmann, Sylvia, Laffer, Brigitte, Marian, Medhat, Shehata, Clemens, Krepler, Hubert, Pehamberger, Thomas, Grunt, Ulrich, Jäger, Christoph C, Zielinski, Peter, Valent   +14 more
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Normal and neoplastic stem cells

Experimental Hematology, 2015
Stem cells are cells that at the single cell level both self-renew and give rise to differentiated progeny. Self renewal is the property that distinguishes stem cells and progenitors, and in the blood-forming system explains why haematopoietic stem cells (HSCs), not progenitors, are the only cells capable of providing rapid and sustained regeneration ...
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Normal and Neoplastic Stem Cells

2012
Recent evidence has revealed the presence of neoplastic stem cells in multiple cancers, both solid and hematological. In this chapter, the similarities and differences between normal and neoplastic stem cells are reviewed, and the basic stem cell definition, function and regulatory pathways in both types of stem cell are addressed, using the ...
Axel Schulenburg, Brigitte Marian
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Potential Non-neoplastic Applications for Polyphenols in Stem Cell Utilization

Current Drug Targets, 2019
While polyphenols may have important effects on pluripotential stem cells that make them noteworthy as potential antineoplastic agents, their action on stem cells may portend other health benefits, such as treatments for cardiovascular and neurocognitive disorders.
E Paul, Cherniack, Sahithi, Chekuri, Heather F, Lee   +2 more
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