Results 41 to 50 of about 119,164 (256)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Towards Differentiation of Viral Encephalitis

Aktualʹnaâ Infektologiâ, 2014
Viral encephalitis is one of the important directions of modern neurology. Practitioners have diagnostic difficulties that require differentiation from neoplastic process, acute cerebral vascular syndromes, toxic encephalopathy, psychosis. In this regard,
T.V. Mironenko, G.A. Pogorelova
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The Usefulness of Diagnostic Vitrectomy in Neoplastic and Non-Neoplastic Masquerade Syndrome: An Observational Study [PDF]

Annals of Hematology & Oncology, 2021
Introduction: Masquerade intraocular inflammation may be considered neoplastic or non- neoplastic masquerades such as primary intraocular lymphoma, leukemia, infectious and inflammatory diseases. These pathologies require a definitive diagnosis, as the treatment modalities are different. The aim of our study was to investigate the safety and usefulness
openaire   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

The Broad Spectrum of Gallbladder Paraneoplastic Syndromes

Gastro Hep Advances
Gallbladder carcinoma (GBC) is a rare gastrointestinal tumor with a reported incidence of 1 in 100,000 in the United States. GBC may present with subtle signs and symptoms that can be missed on routine examination and/or confused with other conditions ...
Shuhaib Ali, Mukarram Jamat Ali, Ammad Javaid Chaudhary, Saad Ur Rehman, Muhammad Arqam Maqsood   +4 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Multigene Germline Panel Testing in Gastric Cancer Patients in a Portuguese Population

Cancer Medicine
Background Gastric cancer is a heterogeneous disease with both environmental and genetic determinants. While Multigene Germline Panel Testing (MGPT) increasingly reveals hereditary predisposition, the prevalence and clinical significance of germline ...
B. Mourato, B. Cordeiro, F. Costa Pinto, N. Pratas, H. Capote, I. Fronteira, M. Areia, R. Dinis   +7 more
doaj   +1 more source

Hipercoagulabilidade neoplásica. A propósito de dois casos com Síndroma de Trousseau.

Acta Médica Portuguesa, 1990
The authors describe two cases with venous thromboembolism and neoplasia (ovary and stomach), which also showed evidence of arterial thromboembolic phenomena--cerebrovascular disease in the 1st case and acute myocardial infarction in the 2nd case ...
J F Sequeira, R M Gomes, M A Gonzalez, J L Sarmento   +3 more
doaj   +1 more source

Endolymphatic Sac Tumour: A Neoplastic Cause for Meniere’s Syndrome [PDF]

Indian Journal of Otolaryngology and Head & Neck Surgery, 2011
Patients with intractable vertigo often present a diagnostic dilemma to the treating physician. A wide spectrum of diseases, ranging from those of the labyrinth onto the central nervous system, may present predominantly with vertigo. In some cases, it requires the clinical acumen of an experienced neuro-otologist, to decipher these vertiginous symptoms
S, Raghunandhan, P, Vijaya Krishnan, Sathiya, Murali, R S, Anand Kumar, Mohan, Kameswaran   +4 more
openaire   +2 more sources