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Neoplastic Transformation Induced by Carbon Ions
International Journal of Radiation Oncology*Biology*Physics, 2009The objective of this experiment was to compare the oncogenic potential of carbon ion beams and conventional photon beams for use in radiotherapy.The HeLa X human skin fibroblast cell line CGL1 was irradiated with carbon ions of three different energies (270, 100, and 11.4 MeV/u). Inactivation and transformation data were compared with those for 15 MeV
D. Bettega +4 more
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The Neoplastic Transformation of SCID Cells by Radiation
Radiation Research, 1999Severe combined immunodeficiency (SCID) cells are hypersensitive to killing by ionizing radiation because of deregulation of DNA-dependent protein kinase (DNA-PK) and a concomitant deficiency in the repair of DNA double-strand breaks. The effect of this condition on the neoplastic transformation of SCID fibroblasts, designated SCID 3T1, has been ...
Mingyue Lun +4 more
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Neoplastic Cell Transformation by Heavy Ions
Radiation Research, 1989We have studied the induction of morphological transformation by heavy ions. Golden hamster embryo cells were irradiated with 95 MeV 14N ions (530 keV/microns), 22 MeV 4He ions (36 keV/microns), and 22 MeV 4He ions with a 100-microns Al absorber (77 keV/microns) which were generated by a cyclotron at the Institute of Physical and Chemical Research in ...
Kazushiro Nakano +4 more
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The mechanisms of neoplastic transformation
European Journal of Cancer, 2001Historically, the contemporary understanding of tumours developed hand in hand with Virchow’s notion that the cell was the basic element of many diseases. Indeed, classical pathology began early on to describe a multitude of cancers, but, at the same time, it was also quick to recognise features that were common to them all, and this led to the concept
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The cytology of spontaneous neoplastic transformation in culture
In Vitro, 1977Thirteen cell lines derived from embryos of the mouse, rat and hamster were sampled at closely spaced intervals for cytology and spontaneous neoplastic transformation. Transformation, determined by growth of the cells as malignant neoplasms in compatible hosts, occurred in eight lines and appeared to be unrelated to time in culture, passage number ...
Ram Parshad +3 more
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Pulsed ultrasound and neoplastic transformation in vitro
Ultrasound in Medicine & Biology, 1991C3H/10T1/2 mouse embryo fibroblast cells grown as 1.2 cm diameter monolayers were assayed for cytotoxicity and neoplastic transformation following 30 min insonations with three types of pulsed ultrasound (US). Two of the US beams, with a repetition frequency of 1 kHz, center frequencies of 2.5 and 3.5 MHz and time-averaged intensities (ITA) of 31 and 6.
Elizabeth K. Balcer-Kubiczek +1 more
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Molecular Biology and Malignancy: Series Introduction Mechanisms of Neoplastic Transformation
Cancer Investigation, 1983This paper introduces a series of invited essays on current controversies in basic cancer research. The initial group of essays focuses on the detection and interpretation of molecular and cellular changes suspected to be of importance in the cause and pathogenesis of cancer. There are two formats: (i) differing viewpoints are presented in parallel, or
J. Monnat Raymond, Lawrence A. Loeb
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Cell surface protein and neoplastic transformation [PDF]
Trends in Biochemical Sciences, 1976 A major fibroblast glycoprotein that is diminished after malignant transformation has been isolated and partially characterized. Reconstitution experiments indicate that the glycoprotein helps maintain normal cell shape, adhesion, and contact inhibition of movement.
Kenneth M. Yamada, Ira Pastan
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Neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma
Human Pathology, 2011Although extraovarian mucinous cystadenocarcinomas resemble primary ovarian carcinomas, both histologically and clinically, their specific etiology is not clear. This is the first report to show neoplastic transformation of endocervicosis into an extraovarian mucinous cystadenocarcinoma. The histologic spectrum and specific KRAS mutational analysis for
Brigitte F. M. Slangen +8 more
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Neoplastic transformation of anal condyloma
Coloproctology, 1997May one speak of precancerous lesion in the presence of perianal condyloma acuminata? In literature there are numerous reports of neoplastic transformation of anal condylomatosis to such an extent as these reports are comparable to extra-mammary Paget’s disease, to the giant condylomatosis of Buschke-Lowenstein and Bowen’s disease.
C. Carli +7 more
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