Results 91 to 100 of about 22,017 (305)

Efficient Total Syntheses of Natural Neopterin Glycosides: Neopterin Glucronide and Solfapterin [PDF]

HETEROCYCLES, 2017
1’,2’-Di-O-acetyl-N2-(N,N-dimethylaminomethylene)-3-[2-(4-nitro- phenyl)ethyl]neopterin (11a) and its 1’,2’-di-O-benzoyl analog (11b) were prepared from neopterin in 5 steps, respectively. Glycosylation of 11a with methyl 2,3,4-tri-O-benzoyl-α-D-glucopyranosyluronate bromide (15b) in the presence of silver triflate afforded the corresponding 3’-O-(β-D ...
Hanaya, Tadashi, Iwasaki, Katsuya, Saeki, Kaori, Hattori, Takafumi   +3 more
openaire   +2 more sources

Niedrig dosierte Ganzhaut‐Elektronenbestrahlung bei erythrodermatischer Mycosis fungoides und Sézary‐Syndrom: Ergebnisse aus der prospektiven S‐MISR‐Studie

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 12, Page 1534-1543, December 2025.
Zusammenfassung Hintergrund Bei der erythrodermatischen Mycosis fungoides (eMF) und dem Sézary‐Syndrom (SS) sind systemische Therapien häufig mit verzögerten und nicht anhaltenden klinischen Remissionen verbunden. Patienten und Methodik 35 Patienten mit eMF und SS wurden mittels Ganzhautelektronenbestrahlung (total skin electron beam therapy, TSEBT ...
Khaled Elsayad, Christian Kandler, Jan Jakob Siats, Niklas Pepper, Moritz Fabian Danzer, Gabor Dobos, Elisabeth Livingstone, Susanne Melchers, Johannes Kleemann, Julia Hyun, Claudia Pföhler, Peter von den Driesch, Jan P. Nicolay, Rudolf Stadler, Hans Theodor Eich   +14 more
wiley   +1 more source

Chapter Five. Systematic review results by biomarker classifications [PDF]

, 2016
5.1 Markers of Absorption and Permeability Overview 5.2 Markers of Absorption 5.3 Markers of Permeability 5.4 Markers of Digestion 5.5 Markers of Intestinal Inflammation and Intestinal Immune Activation 5.6 Markers of Systemic Inflammation and Systemic ...
Denno, Donna M, Musser, Christine A, Nelson, Zakia C, Tarr, Phillip I, VanBuskirk, Kelley M   +4 more
core   +1 more source

Consensus Guideline for the Diagnosis and Treatment of Tyrosine Hydroxylase (TH) Deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Tyrosine hydroxylase (TH) catalyses the rate‐limiting step in dopamine biosynthesis. Autosomal recessive tyrosine hydroxylase deficiency (THD) leads to clinical phenotypes reflecting the deficiency of dopamine, norepinephrine, or epinephrine in the central nervous system (CNS), presenting along a continuous spectrum from mild to severe forms ...
Mariya Sigatullina Bondarenko, Oya Kuseyri Hübschmann, Jan Kulhánek, Roser Pons, Toni S. Pearson, Kathrin Jeltsch, Ivana Badnjarevic, Tessa Wassenberg, Gabriella Horvath, Galina Stevanovic, Manju A. Kurian, Elisenda Cortès‐Saladelafont, Agathe Roubertie, Vincenzo Leuzzi, Mariarita Bertoldi, Mario Mastrangelo, Birgit Assmann, THD Guidelines Working Group, Ines Denzler, Clarisa Maxit, Natalia Alexandra Julia‐Palacios, Shekeeb Mohammad, Helly Goez, Wai‐Ian Yeung, Tomáš Honzík, Ivana Kavecan, Alba Tristán‐Noguero, Alberto Burlina, Daniela Gueraldi, Sushil Bandodkar, Willemsen Michel, Francesco Porta, Sheila Wong, Filippo Manti, Reem Alkhater, Chris Mühlhausen, Alice Kuster, Dimitrios Zafeiriou, Paulo Sgobbi, Wladimir Bocca Vieira de Rezende Pinto, Angeles Garcia‐Cazorla, Thomas Opladen   +41 more
wiley   +1 more source

Cerebrospinal Fluid From Patients With HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) With Rapid Evolution Affects Mitochondrial DNA Transcription and Network Organization in Human Glioblastoma Cells

Journal of Medical Virology, Volume 97, Issue 11, November 2025.
ABSTRACT Human T‐lymphotropic virus 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive neurodegenerative disease affecting motor and sensory functions. While alterations in cerebrospinal fluid (CSF) have been used to identify disease biomarkers, the effects of such modified CSF on CNS cells remain unexplored.
Yago Côrtes Pinheiro Gomes, Alice Bongers, Patricia Jeannin, Ana Carolina Paulo Vicente, Antoine Gessain, Philippe V. Afonso, Otavio Melo Espindola   +6 more
wiley   +1 more source

Cytokine induction of neopterin production

Clinical and Experimental Immunology, 1991
SUMMARYThe pteridine neopterin is a marker of immunological activation and has been shown to be a useful marker of graft-versus-host disease (GVHD) in bone marrow transplant patients. High levels of both neopterin and interferon-gamma (IFN-γ) were produced in vitro during mixed lymphocyte responses, which may be considered to be a model of the primary ...
D C, Henderson, J, Sheldon, P, Riches, J R, Hobbs   +3 more
openaire   +3 more sources

Assessment of neopterin and indoleamine 2,3‐dioxygenase activity in patients with seasonal influenza: A pilot study

Influenza and Other Respiratory Viruses, 2019
Seasonal influenza is an important cause of morbidity and mortality worldwide. Immune activation after stimulation with interferon‐gamma leads to increased production of neopterin but also results in increased tryptophan catabolism through indoleamine 2 ...
A. Pizzini, K. Kurz, Janine Santifaller, Christoph Tschurtschenthaler, I. Theurl, D. Fuchs, G. Weiss, R. Bellmann-Weiler   +7 more
semanticscholar   +1 more source

Adult‐Onset Acute Cerebellar Ataxia with Preceding Essential Tremor‐like Syndrome Associated with a Novel Variant in ATP1A3

Movement Disorders Clinical Practice, EarlyView.
Lukas Gattermeyer‐Kell, Sebastian Franthal, Maria Tscherner, Mariella Kögl, Petra Katschnig‐Winter, Christian Windpassinger, Petra Schwingenschuh   +6 more
wiley   +1 more source

Assessment of Metabolic Parameters For Autism Spectrum Disorders [PDF]

, 2009
Autism is a brain development disorder that first appears during infancy or childhood, and generally follows a steady course without remission. Impairments result from maturation-related changes in various systems of the brain.
Ghosh, S, Koch, M, Rao, Mr AN, Shobha, G, Suresh Kumar, V   +4 more
core  

Clinical Characteristics of Parkinsonism in HTLV‐1‐Associated Myelopathy

Annals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 1962-1970, October 2025.
ABSTRACT Objective Human T‐lymphotropic virus type 1 (HTLV‐1)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the classic neurological manifestation of HTLV‐1 infection; however, this virus has also been associated with other neurological disorders. Concurrent parkinsonism is relatively rare and presents diagnostic challenges.
Mika Dozono, Satoshi Nozuma, Shota Hirakata, Takashi Yoshida, Daisuke Kodama, Masakazu Tanaka, Eiji Matsuura, Ryuji Kubota, Hiroshi Takashima   +8 more
wiley   +1 more source