Results 101 to 110 of about 22,017 (305)

Urinary Neopterin Concentrations in Healthy Individuals with Household Contact

open access: yesPteridines, 2003
Increased neopterin concentrations in serum and urine indicate activation of cell-mediated immunity. In this study, urinary neopterin concentrations of a family consisting of 1 child (aged 5 years), her parents, and her grandparents were determined over ...
Winkler Christiana   +3 more
doaj   +1 more source

Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure

open access: yesJournal of Clinical Medicine, 2019
Inflammation and immune activation play an important role in the pathogenesis of cardiac remodelling in patients with heart failure. The aim of this study was to assess whether biomarkers of inflammation and immune activation are linked to disease ...
L. Lanser   +4 more
semanticscholar   +1 more source

Elevated neopterin levels in wild, healthy chimpanzees indicate constant investment in unspecific immune system

open access: yesBMC Zoology, 2019
BackgroundEcological immunology proposes that the optimal immune defence, and the costs coming with it, vary across environments. In environments with higher pathogen load, the immune system should experience greater challenges and, therefore, investment
V. Behringer   +6 more
semanticscholar   +1 more source

A Systematic Review and Meta‐Analysis of the Role of Peripheral Inflammation in Delirium

open access: yesBrain and Behavior, Volume 15, Issue 10, October 2025.
This review found peripheral inflammation is associated with delirium. Preceding delirium, the neutrophil‐to‐lymphocyte ratio (NLR), interleukin‐6 (IL‐6), C‐reactive protein (CRP), and Leukocyte Count(WBC) were higher, and insulin‐like growth factor‐1 (IGF‐1) lower, in those that developed delirium.
Hannah C. Moorey   +4 more
wiley   +1 more source

Urinary Neopterin in Patients with Ovarian Cancer

open access: yesPteridines, 2006
Urinary neopterin, an indicator of systemic immune activation, is increased in most patients with epithelial ovarian carcinoma (EOC) and is an independent prognostic indicator.
Melichar Bohuslav   +8 more
doaj   +1 more source

Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice

open access: yesItalian Journal of Pediatrics, 2019
Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121,
A. Licari   +3 more
semanticscholar   +1 more source

Characterization of Proteomic Pharmacodynamic Biomarkers of IFNβ‐1a Biologics to Inform Potential Utility in Biosimilar Development

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 4, Page 935-945, October 2025.
Pharmacodynamic (PD) biomarkers can support biosimilarity assessment, potentially reducing the need for comparative clinical efficacy studies. This study aimed to characterize previously identified proteomic PD biomarker candidates for Interferon beta‐1a (IFNβ‐1a, n = 248) and pegylated IFNβ‐1a (pegIFNβ‐1a, n = 528) biologics at therapeutic doses, to ...
Lakshmi Manasa S. Chekka   +15 more
wiley   +1 more source

Salivary neopterin concentrations in patients with cancer of the oral cavity

open access: yesPteridines, 2016
Tumors of the oral cavity are relatively common malignancies with a poor prognosis. Use of both prognostic and predictive biomarkers in saliva represents one approach to improve the management of patients with these cancers.
Pink Richard   +5 more
doaj   +1 more source

Changes in C-reactive protein, neopterin and lactoferrin differ after conservative and surgical weight loss in individuals with morbid obesity

open access: yesScientific Reports, 2019
C-reactive protein, neopterin and lactoferrin are biomarkers of atherosclerotic disease. We aimed to assess changes in these biomarkers after conservative and surgical weight loss interventions in individuals with morbid obesity, to evaluate associations
M. Aasbrenn, P. Farup, V. Videm
semanticscholar   +1 more source

Clinical Value of Neopterin In Infectious Complications

open access: yesPteridines, 1999
Neopterin, a pteridine intermediate metabolite in the biopterine synthetic pathway, is synthesized and secreted by monocyte/macrophages upon stimulation, mainly by gamma-interferon by activated T cells.
Iwagaki Hiromi   +5 more
doaj   +1 more source

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