Results 111 to 120 of about 22,017 (305)

CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation

EBioMedicine, 2023
Jingya Yan, K. Kothur, S. Mohammad, J. Chung, Shrujna Patel, H. Jones, Brooke A. Keating, V. Han, R. Webster, S. Ardern–Holmes, J. Antony, M. Menezes, E. Tantsis, D. Gill, Sachin Gupta, T. Kandula, H. Sampaio, M. Farrar, C. Troedson, P. Andrews, Sekhar C. Pillai, B. Heng, Gilles J. Guillemin, Adnan Guller, S. Bandodkar, Russell C. Dale   +25 more
semanticscholar   +1 more source

Novel neuropathological observations in an adult with Dravet syndrome

Epilepsia, Volume 66, Issue 10, Page e236-e241, October 2025.
Abstract Dravet syndrome (DS) is a developmental and epileptic encephalopathy associated with pathogenic variants in the SCN1A gene. The neuropathological features of adult DS remain poorly understood. We report the postmortem findings of a 55‐year‐old woman with DS due to a confirmed SCN1A pathogenic variant leading to Nav1.1 loss of function ...
Danielle M. Andrade, Anne S. Bassett, Quratulain ZulfiqarAli, Victor S. T. Lira, Nikolai Gil Reyes, M. Carmela Tartaglia, Alfonso Fasano, Gabor G. Kovacs   +7 more
wiley   +1 more source

Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience [PDF]

, 2018
In every newborn with even mild hyperphenylalaninemia (HPA) tetrahydrobiopterin (BH4) deficiencies need to be excluded as soon as possible. Differential diagnosis is most commonly performed by analysis of urinary neopterin and biopterin.
Abu Seda, Bettina, Blau, Nenad, Hoffmann, Georg, Opladen, Thomas, Rassi, Anahita, Thöny, Beat   +5 more
core  

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability [PDF]

, 2005
Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
Clapp, BR, Deanfield, JE, Gallimore, JR, Hineorani, AD, Hirschfield, GM, MacAllister, RJ, Pepys, MB, Singer, M, Stidwill, RP, Storry, C, Vallance, P   +10 more
core   +1 more source

The physiological and mononuclear cell activation response to cryotherapy following a mixed martial arts contest: a pilot study

Pteridines, 2015
Cold water immersion is thought to reduce the inflammatory response to injury. Using cultured mononuclear cells and human subjects in a mixed martial arts (MMA) contest, we examined the effect of cryotherapy on 7,8-dihydroneopterin and neopterin ...
Lindsay Angus, Carr Sam, Othman Mohd Izani, Marks Edward, Davies Sian, Petersen Carl, Draper Nick, Gieseg Steven P.   +7 more
doaj   +1 more source

Clinical importance of serum neopterin level in patients with pulmonary tuberculosis

International Journal of Mycobacteriology, 2014
Objective: Neopterin is a sensitive marker for cell-mediated immune response. Because of this, the neopterin levels of body fluids show cell-mediated immune response in different infectious diseases which involve T cells and macrophages.
Salih Cesur, Turan Aslan, Nevin Taci Hoca, Filiz Çimen, Gülnur Tarhan, Aydın Çifçi, İsmail Ceyhan, Tuğrul Şipit   +7 more
doaj   +1 more source

LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.

Bioanalysis, 2016
AIM The kynurenine (KYN) pathway is implicated in diseases such as cancer, psychiatric, neurodegenerative and autoimmune disorders. Measurement of KYN metabolite levels will help elucidating the involvement of the KYN pathway in the disease pathology and
R. Fuertig, A. Ceci, S. Camus, E. Bézard, Andreas H. Luippold, B. Hengerer   +5 more
semanticscholar   +1 more source

Pre‐Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness

Aging Cell, Volume 24, Issue 9, September 2025.
Pre‐vaccination immune profiles and a novel biomarker, immune entropy, are associated with responsiveness to influenza, pneumococcal, and SARS‐CoV‐2 vaccines, independent of age, sex, and CMV serostatus, and also correlate with inflammaging‐related serum proteins, supporting their potential as indicators of immunosenescence validated across diverse ...
Alper Cevirgel, Marieke van der Heiden, Sudarshan A. Shetty, Markus Viljanen, Martijn Vos, Elske Bijvank, Yannick van Sleen, Celine Imhof, Joeri A. J. Rolwes, Leonard Daniël Samson, Lisa Beckers, Nynke Rots, Josine van Beek, Anne‐Marie Buisman, Debbie van Baarle   +14 more
wiley   +1 more source

Urinary neopterin levels increase and predict survival during a respiratory outbreak in wild chimpanzees (Taï National Park, Côte d’Ivoire)

Scientific Reports, 2018
Monitoring immune system activation of wild animals has garnered increasing interest within the field of ecological immunology, leading to an urgent need for non-invasive biomarkers measuring these changes.
Doris F. Wu, V. Behringer, R. Wittig, F. Leendertz, T. Deschner   +4 more
semanticscholar   +1 more source

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core   +2 more sources