Results 51 to 60 of about 17,150 (201)

A RP-HPLC Method for the Analysis of Neostigmine Methylsulfate and Process-Related Impurities, Forced Degradation Studies, in the Injection Formulation

International Journal of Analytical Chemistry, 2021
Neostigmine methylsulfate is an anticholinesterase agent and is clinically used for treating myasthenia gravis. It is also used for reversing nondepolarising neuromuscular blocking agents.
Manali Parab, Vaishali A. Shirsat, Yogita M. Kodgule, Mandar Kodgule   +3 more
doaj   +1 more source

Preventing Isolated Perioperative Reintubation: Who is at highest risk? [PDF]

, 2017
Objectives: 1. We aim to characterize IPR nationally through a retrospective review of the National Surgical Quality Improvement Program participant user file (NSQIP PUF).
Bauer, MD, Tyler M., Cowan, MD, Scott W., Goldhammer, MD, Jordan E., Johnson, MD, Adam P., Kelz, MD, Rachel R., Wirtalla, MD, Chris   +5 more
core   +1 more source

Economic evidence for licensed ready‐to‐administer intravenous products compared with standard vials and ampoules: a systematic review

Anaesthesia, EarlyView.
Summary Introduction Injectable medicines represent a significant proportion of the annual medicines expenditure of the NHS in England, totalling £7 billion ($9.4 billion, €8.0 billion) in 2023. This represents approximately 70% of hospital medicines spending and includes essential treatments delivered at the point of care, such as chemotherapy ...
Suzanne Al‐Rawi, Matthew Greening, Sue Ladds   +2 more
wiley   +1 more source

Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. [PDF]

, 2013
Synthesis of acetylcholine (ACh) by non-neuronal cells is now well established and plays diverse physiologic roles. In neurons, the Na(+) -dependent, high affinity choline transporter (CHT1) is absolutely required for ACh synthesis. In contrast, some non-
Campling, M.D., FRCPC, Barbara, Dissen, Gregory A, Lindstrom, Jon, Rekow, Stephen S, Sekhon, Harmanjatinder S, Singleton, Corey-Ayne, Song, Pingfang, Spindel, Eliot R, Zhou, Minerva   +8 more
core   +1 more source

Effect of Linaclotide on Colonic Motility Assessed With Intraluminal Colonic High‐Resolution Manometry in Healthy Subjects. An Acute, Open Label, Randomized, Crossover, Reader‐Blinded Study

Neurogastroenterology &Motility, EarlyView.
Our study showed that, in healthy controls, acute administration of linaclotide increased the total number of long‐distance propagating and the pre‐prandial pancolonic pressurizations. Further studies need to address whether the observed effects are directly or indirectly mediated by the mechanism of action of this useful medication to treat chronic ...
Christian Lambiase, Giuseppe Pagliaro, Silvia Cocca, Eveline Deloose, Ingrid Demedts, Riccardo Morganti, Jan Tack, Maura Corsetti   +7 more
wiley   +1 more source

Functional respiratory imaging after neostigmine- or sugammadex-enhanced recovery from neuromuscular blockade in the anesthetised rat: a randomised controlled pilot study

Revista Brasileira de Anestesiologia
Objectives Reductions in diaphragm activity are associated with the postoperative development of atelectasis. Neostigmine reversal is also associated with increased atelectasis. We assessed the effects of neostigmine, sugammadex, and spontaneous reversal
Tom Schepens, Guy Cammu, Sabine Maes, Benny Desmedt, Wim Vos, Kristof Deseure   +5 more
doaj   +1 more source

Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To compare the effects of sugammadex and neostigmine, used to antagonize the effects of rocuronium, on the QTc interval. METHODS: This study used 10 adult New Zealand white rabbits of 2.5-3.5 kg randomly divided into two groups: sugammadex group
Mesut Erbaş, Hüseyin Toman, Hasan Şahin, Hasan Ali Kiraz, Ahmet Barutcu, Tuncer Simsek, Ali Umit Yener, Metehan Uzun, Uğur Altınışık   +8 more
doaj   +2 more sources

Early treatment with intranasal neostigmine reduces mortality in a mouse model of Naja naja (Indian Cobra) envenomation [PDF]

, 2014
Objective. Most snakebite deaths occur prior to hospital arrival; yet inexpensive, effective, and easy to administer out-of-hospital treatments do not exist. Acetylcholinesterase inhibitors can be therapeutic in neurotoxic envenomations when administered
Bickler, Philip, Lewin, Matthew R., Mensh, Brett D., Samuel, Stephen P., Vaiyapuri, Sakthi, Wexler, David S.   +5 more
core   +3 more sources

Experience Using Efgartigimod to Treat Juvenile Myasthenia Gravis in China: A Multicenter Retrospective Study

Muscle &Nerve, Volume 73, Issue 6, Page 1025-1031, June 2026.
ABSTRACT Introduction/Aims Current therapeutic management of juvenile myasthenia gravis (JMG) predominantly relies on conventional immunosuppressive therapies and expert consensus extrapolated from adult data, creating a critical gap in high‐quality, pediatric‐specific clinical evidence.
Jing Lin, Guoyan Qi, Susan Luo, Qilong Jiang, Bitao Bu, Min Liu, Yuzhen Wei, Meigui Han, Junhong Yang, Zhilan Zhao, Lili Zhang, Yifan Zhang, Haoyou Xu, Xingjie Hao, Zhijun Li   +14 more
wiley   +1 more source

Respiratory muscle activity after spontaneous, neostigmine- or sugammadex-enhanced recovery of neuromuscular blockade: a double blind prospective randomized controlled trial

BMC Anesthesiology, 2019
Background The use of neostigmine after neuromuscular blockade (NMB) has been associated with postoperative respiratory complications. In previous studies, we found lower diaphragmatic activity after neostigmine reversal of NMB, compared to sugammadex ...
Tom Schepens, Koen Janssens, Sabine Maes, Davina Wildemeersch, Jurryt Vellinga, Philippe G. Jorens, Vera Saldien   +6 more
doaj   +1 more source