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American Journal of Ophthalmology, 2010
With regard to the power calculations please note the following. The population covered by the present study consists of all subjects potentially affected with myopic CNV. It is a population of modalities, and therefore, is unlimited. The sample was selected according to inclusion and exclusion criteria, mentioned in the “Methods.” From a statistical ...
GHARBIYA, Magda, GIUSTOLISI, Rosalia, ALLIEVI F, FANTOZZI N, MAZZEO L, SCAVELLA V, BALACCO GABRIELI C.   +6 more
openaire   +3 more sources

RhoA/ROCK Signaling Is Involved in Pathological Retinal Neovascularization

Journal of Vascular Research, 2023
Objective: The aim of the study was to evaluate the effect of the RhoA/ROCK inhibitor Fasudil on retinal neovascularization (NV) in vivo and angiogenesis in vitro. Methods: C57BL/6 was used to establish an OIR model. First, RhoA/ROCK expression was first examined and compared between OIR and healthy controls. Then, we evaluated the effect of Fasudil on
Fen, Tang, Kongqian, Huang, Biyan, Peng, Wen, Deng, Ning, Su, Fan, Xu, Mingyuan, Zhang, Haibin, Zhong   +7 more
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Pathology of plaque haemorrhage and neovascularization of coronary artery

Journal of Cardiovascular Medicine, 2012
Intraplaque haemorrhage (IPH) is thought to play crucial roles in plaque progression and plaque rupture, resulting in acute coronary syndromes, which are the leading causes of morbidity and mortality in the developed countries. IPH is a common finding in atherosclerotic plaques.
Manuela Agozzino, Nupoor Narula, Takahide Kodama, Eloisa Arbustini   +3 more
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Characteristics of Periconus Choroidal Neovascularization in Pathologic Myopia

American Journal of Ophthalmology, 2011
To examine the clinical characteristics of periconus choroidal neovascularizations (CNVs) in eyes with pathologic myopia.Retrospective observational case series.We reviewed the medical records of 260 eyes of 254 patients with a myopic CNV and selected those with a periconus CNV.
Muka Moriyama, Natsuko Nagaoka, Kengo Hayashi, Takeshi Yoshida, Takashi Tokoro, Noriaki Shimada, Wakako Hayashi, Kyoko Ohno-Matsui   +7 more
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The pathology of abortive neovascular outgrowths from the retina

Graefe's Archive for Clinical and Experimental Ophthalmology, 1992
Seven abortive neovascular outgrowths (ANVOs) from diabetic retinas were obtained for examination either by biopsy during pars plana vitrectomy (2) or after discovery within enucleated globes (5). Scanning and electron microscopical, histochemical, immunohistochemical and retinal digest techniques were used.
Alec Garner, R J Cooling, Paul Rosen, P Hiscott   +3 more
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INTRAVITREAL RANIBIZUMAB FOR CHOROIDAL NEOVASCULARIZATION COMPLICATING PATHOLOGIC MYOPIA

Retina, 2010
The purpose of this study was to evaluate the efficacy of intravitreal injections of ranibizumab in choroidal neovascularization secondary to pathologic myopia.A prospective case series of 32 eyes of 32 patients affected with choroidal neovascularization secondary to pathologic myopia treated by intravitreal injections of ranibizumab.
Lalloum F, Souied EH, Bastuji Garin S, Puche N, QUERQUES , GIUSEPPE, Glacet Bernard A, Coscas G, Soubrane G, Leveziel N.   +8 more
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Inhibition of Pathological Retinal Neovascularization by α-Defensins.

Blood, 2005
Abstract Proliferative retinopathies, such as those complicating prematurity and diabetes, are major causes of blindness. A prominent feature of these retinopathies is excessive neovascularization, which is orchestrated by the hypoxia-induced vascular endothelial growth factor (VEGF) stimulating endothelial cells, and the integrin ...
Franz Fogt, Hans-Peter Hammes, Matina Economopoulou, Klaus T. Preissner, Khalil Bdeir, Douglas B. Cines, Triantafyllos Chavakis, Jacek Lubkowski, Yasmina Bdeir   +8 more
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LACQUER CRACK FORMATION AND CHOROIDAL NEOVASCULARIZATION IN PATHOLOGIC MYOPIA

Retina, 2008
To clarify the characteristics of choroidal neovascularization (CNV) due to myopic CNV (mCNV) and the relation to lacquer crack (LC) formation.Thirty-seven eyes with mCNV underwent fluorescein angiography (FA) and indocyanine green angiography (ICGA) using Heidelberg Retina Angiograph 2 (HRA2; Heidelberg, Germany). mCNV was detected by FA and ICGA; LCs
Kaori Sayanagi, Motokazu Tsujikawa, Yasuo Tano, Miki Sawa, Yasushi Ikuno, Fumi Gomi, Kaori Soga   +6 more
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Neuropilin-1 is upregulated in Sjögren’s syndrome and contributes to pathological neovascularization

Histochemistry and Cell Biology, 2012
Neuropilin-1 (NRP1) is a transmembrane co-receptor for members of the vascular endothelial growth factor family. Recent studies revealed an important role of NRP1 in angiogenesis and progression of many diseases. The role of NRP1 in the development of Sjögren's syndrome (SS), one of the most common rheumatic diseases, has not yet been investigated ...
Sisto M, Lisi S, LOFRUMENTO, Dario Domenico, D'Amore M, Ribatti D.   +4 more
openaire   +5 more sources

INTRAVITREAL BEVACIZUMAB FOR EXTRAFOVEAL CHOROIDAL NEOVASCULARIZATION SECONDARY TO PATHOLOGIC MYOPIA

Retina, 2013
To assess the effects of intravitreal bevacizumab injections in the treatment of extrafoveal choroidal neovascularization (CNV) associated with pathologic myopia.Patients diagnosed with pathologic myopia complicated by extrafoveal CNV were considered in this prospective, open-label interventional study.
Parodi MB, Iacono P, Papayannis A, Kontadakis S, Cascavilla ML, Zucchiatti I, BANDELLO , FRANCESCO   +6 more
openaire   +4 more sources