Results 71 to 80 of about 1,067,090 (283)

Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization [PDF]

EMBO Molecular Medicine, 2016
AbstractAge‐related macular degeneration in its neovascular form (NV AMD) is the leading cause of vision loss among adults above the age of 60. Epidemiological data suggest that in men, overall abdominal obesity is the second most important environmental risk factor after smoking for progression to late‐stage NV AMD.
Elisabeth MMA Andriessen, Ariel M Wilson, Gaelle Mawambo, Agnieszka Dejda, Khalil Miloudi, Florian Sennlaub, Przemyslaw Sapieha   +6 more
openaire   +3 more sources

3D‐Printed Multidimensional Bionic Mg‐MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects

Advanced Healthcare Materials, EarlyView.
This study develops 3D‐printed Mg‐MC/PLGA scaffolds with varying Mg concentrations (0–20%). The 5% Mg scaffold shows optimal cytocompatibility, osteogenic activity in vitro, and significantly enhances bone regeneration in rabbits, improving bone volume and mechanical strength.
Shihang Liu, Shuai Zhou, Tingting Zou, Guangzhao Hou, Qian Xiao, Lin Li, Jianjun Yang, Wei Chen, Yingze Zhang, Hongzhi Lv   +9 more
wiley   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Co‐Delivery of Ca‐MOF and Mg‐MOF Using Nanoengineered Hydrogels to Promote In Situ Mineralization and Bone Defect Repair: In Vitro and In Vivo Analysis

Advanced Healthcare Materials, EarlyView.
Metal‐organic frameworks (MOFs) have been synthesized using calcium (Ca‐MOF), magnesium (Mg‐MOF), and as hybrids (Ca/Mg‐MOF) for bone healing applications. MOFs are integrated into hydrogel polymer networks for injectable, sprayable, and coating applications.
Cho‐E Choi, Chao Liang, Yasmeen Shamiya, Sang Jin Lee, Arghya Paul   +4 more
wiley   +1 more source

Insights into myopic choroidal neovascularization based on quantitative proteomics analysis of the aqueous humor

BMC Genomics, 2023
Background Previous studies on the biomarkers of pathologic myopia choroidal neovascularization (pmCNV) development merely detected limited types of proteins and provide a meagre illustration of the underlying pathways.
Huimin Yu, Zheng Zhong, Yin Zhao, Huan Luo, Jinfu Sun, Ruohong Wang, Xian Zhang, Xufang Sun   +7 more
doaj   +1 more source

Development of a Vaginal Extracellular Matrix Hydrogel for Combating Genitourinary Syndrome of Menopause

Advanced Materials, EarlyView.
In this study, a vaginal specific ECM hydrogel (vECM) is developed, optimized for intravaginal topical administration, and evaluated for mitigatation of vaginal atrophy associated with menopause. When applied in a rat model of menopause, vECM improves vaginal epithelial thickness and stem cell phenotype, and despite topical application, vECM also ...
Emma I. Zelus, Jacqueline Grime, Anthony Saviola, Maxwell McCabe, Kirk C. Hansen, Marianna Alperin, Karen L. Christman   +6 more
wiley   +1 more source

Bcl-2 Expression in Pericytes and Astrocytes Impacts Vascular Development and Homeostasis

Scientific Reports, 2019
B-cell lymphoma 2 (Bcl-2) protein is the founding member of a group of proteins known to modulate apoptosis. Its discovery set the stage for identification of family members with either pro- or anti-apoptotic properties.
Ismail S. Zaitoun, Catherine M. Wintheiser, Nasim Jamali, Shoujian Wang, Andrew Suscha, Soesiawati R. Darjatmoko, Katherine Schleck, Barbara A. Hanna, Volkhard Lindner, Nader Sheibani, Christine M. Sorenson   +10 more
doaj   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, EarlyView.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

Sacrificial Biofabrication for Vascularization: Concept, Materials, Technologies, and Applications

Advanced Materials, EarlyView.
Vasculature is indispensable for tissue viability in regenerative medicine. The sacrificial biofabrication enables precise fabrication of vascular channels by using temporary templates that are subsequently removed. This review defines the concept and delves into sacrificial materials, surrounding materials, fabrication technologies, and biomedical ...
Jiezhong Shi, Chunyao Wang, Xuan Mei, Ben Zhang, Junxi Wu, Rylie A. Green, Yu Shrike Zhang, Wenmiao Shu   +7 more
wiley   +1 more source