Results 71 to 80 of about 1,063,550 (325)

Propranolol inhibition of β-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy.

Investigative Ophthalmology and Visual Science, 2012
PURPOSE Retinopathy of prematurity (ROP) is a leading cause of blindness in children and is, in its most severe form, characterized by uncontrolled growth of vision-threatening pathologic vessels. Propranolol, a nonselective β-adrenergic receptor blocker,
J. Chen, Jean-Sébastien Joyal, Colman J. Hatton, Aimee M. Juan, Dorothy T. Pei, Christian G. Hurst, Dan Xu, A. Stahl, A. Hellstrom, Lois E. H. Smith   +9 more
semanticscholar   +1 more source

Anionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration

Advanced Functional Materials, EarlyView.
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski, Jeremiah Easley, Richard Tuan Tran, Su Chin Heo   +12 more
wiley   +1 more source

Myeloid cell modulation by a GLP-1 receptor agonist regulates retinal angiogenesis in ischemic retinopathy

JCI Insight, 2021
Ischemic retinopathies including diabetic retinopathy are major causes of blindness. Although neurons and Müller glia are recognized as important regulators of reparative and pathologic angiogenesis, the role of mononuclear phagocytes (MPs ...
Lingli Zhou, Zhenhua Xu, Yumin Oh, Rico Gamuyao, Grace Lee, Yangyiran Xie, Hongkwan Cho, Seulki Lee, Elia J. Duh   +8 more
doaj   +1 more source

Intravitreal anti-VEGF therapy for choroidal neovascularisation secondary to pathological myopia: 4-year outcome [PDF]

, 2013
OBJECTIVE: To report the visual outcome after 4-year follow-up in a series of highly myopic eyes with choroidal neovascularisation (CNV) treated with antivascular endothelial growth factor (anti-VEGF) drugs.
Arias, L, Carneiro, A, Montero, JA, Ruiz-Moreno, JM, Silva, R   +4 more
core   +1 more source

Kirigami‐Inspired Breathable Smart Contact Lens for Wireless Monitoring of Corneal Hypoxia and Microenvironment

Advanced Healthcare Materials, EarlyView.
A kirigami‐inspired breathable smart contact lens is reported for wireless monitoring of corneal hypoxia and microenvironment. The ultrathin (55 µm) and flexible sensing device enables digitalized, in situ and precise monitoring of dissolved oxygen, humidity, and temperature (R2 >0.98).
Jiaxue Zhu, Ling Yang, Qing Yang, Yin Huang, Yuhang Li, Yueqing He, Xuxu Yang, Zhiyan Yang, Yonghong Jiao, Wenbin Wei, Yihao Chen, Xue Feng   +11 more
wiley   +1 more source

Aganirsen Antisense Oligonucleotide Eye Drops Inhibit Keratitis-Induced Corneal Neovascularization and Reduce Need for Transplantation: The I-CAN Study. [PDF]

, 2014
OBJECTIVE: Eye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrate-1 expression, inhibited corneal neovascularization in a previous dose-finding phase II study. We aimed to confirm these results in a phase III study and
Al Mahmood, S., Bachmann, B., Bock, F., Böhringer, D., Colin, S., Cursiefen, C., Ferry, A., Frueh, B., Geerling, G., Geudelin, B., Kadlecová, P., Lévy, M., Majo, F., Meller, D., Meyer-Ter-Vehn, T., Pleyer, U., Reinhard, T., Seitz, B., Thorin, E., Viaud, E., Wilhelm, F.   +20 more
core   +1 more source

Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction

Advanced Materials, EarlyView.
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Madeline P. Hopps, JoJo J. Holm, Quincy P. Lyons, Michael B. Nguyen, Jervaughn D. Hunter, Assa Magassa, Elyse G. Wong, Kate Reimold, Sriya N. Paleti, Emily Gardner, Matthew P. Thompson, Colin G. Luo, Xiaoyu Zhang, Karen L. Christman, Nathan C. Gianneschi   +17 more
wiley   +1 more source

Inhibition of choroidal and corneal pathologic neovascularization by Plgf1-de gene transfer.

Investigative Ophthalmology and Visual Science, 2012
PURPOSE Ocular neovascularization (NV), the primary cause of blindness, typically is treated via inhibition of VEGF-A activity. However, besides VEGF-A, other proteins of the same family, including VEGF-B and placental growth factor (PlGF, all together ...
Valeria Tarallo, S. Bogdanovich, Yoshio Hirano, L. Tudisco, L. Zentilin, M. Giacca, J. Ambati, S. De Falco   +7 more
semanticscholar   +1 more source

Structured Light Projection Using Image Guide Fibers for In Situ Photo‐biofabrication

Advanced Materials, EarlyView.
Light‐based biofabrication is typically performed with single wavelength light sources and within benchtop devices. This work demonstrates FaSt‐Light (Fiber‐assisted Structured Light) as a new approach to achieve multiwavelength image projection using flexible image guide fibers, which enables a variety of applications for in situ biofabrication ...
Parth Chansoria, Michael Winkelbauer, Shipin Zhang, Jakub Janiak, Hao Liu, Dimitar Boev, Andrea Morandi, Rachel Grange, Marcy Zenobi‐Wong   +8 more
wiley   +1 more source

Can the application of computed tomography laser mammography (CTLM) in dense breast (category 3,4 according to ACR) examinations combined with x-ray mammography enhance the detection of breast cancer? [PDF]

, 2009
Background: The aim of this study was an attempt to answer the question whether laser mammography in dense breast (classified as category 3,4 according to ACR) examination together with x-ray mammography can enhance the detection of breast cancer ...
Adamiak, Dagmara, Bobek-Billewicz, Barbara, Gorczewski, Kamil, Sczasny, Monika, Stasiak-Preis, Gabriela, Steinhof-Radwańska, Katarzyna, Stobiecka, Ewa   +6 more
core