Results 111 to 120 of about 97,146 (264)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Adopted parameter values for the neovascularization simulations.

, 2018
Adopted parameter values for the neovascularization simulations.
Philip K. Maini (108832), Helen M. Byrne (224868), James A. Grogan (4925707), Joe M. Pitt-Francis (3743929), Anthony J. Connor (4925710)   +4 more
core   +1 more source

Hydrogel‐Based Bioelectronics: From Therapy and Sensing to Neuromorphic Computation

FlexTech, EarlyView.
This review establishes a material–conduction–property–application framework connecting hydrogel chemistry and charge transport with therapy, sensing, closed‐loop feedback, and neuromorphic computation. ABSTRACT Bioelectronics establish bidirectional communication between living systems and electronic devices, providing an enabling platform for ...
Jianlong Hong, Jiaqi Lu, Yijun Hao, Ning Ren, Shuhan He, Haobo Qi, Jingfeng Xu, Chengkuo Lee   +7 more
wiley   +1 more source

Neovascularization in Tissue Engineering

, 2012
A prerequisite for successful tissue engineering is adequate vascularization that would allow tissue engineering constructs to survive and grow. Angiogenic growth factors, alone and in combination, have been used to achieve this, and gene therapy has ...
Dominique Shum-Tim, Jennifer C.-Y. Chung, Jennifer Chung, Jennifer C. -y. Chung   +3 more
core   +1 more source

Engineering an artificial trachea: Quantitative benchmarks and modular strategies for mechanics, epithelialization, and vascular integration

FlexMat, EarlyView.
In this work, we first examine the limitations of surgical repair and stenting, including migration, granulation, mucus plugging, and infection. We then translate these failures into engineering constraints involving geometry, mechanics, fixation, degradation, junctional stress, and remodeling.
Yiwei Xu, Hanqing Dai, Qianwang Ye, Wanlu Zhang, Na Wang, Lei Xiong, Ruiqian Guo   +6 more
wiley   +1 more source

Hypercapnia prevents neovascularization via nitrative stress.

, 2006
Neovascularization after an ischemic insult is a beneficial attempt to salvage the injured tissue. Yet, despite the production of angiogenic factors within ischemic tissues, compensatory growth of new vessels fails to provide adequate vascularization ...
Sylvain Chemtob, Sennlaub, Florian, Tang Zhu, Zhu, Tang, Florian Sennlaub, Hardy, Pierre, Sirinyan, Mirna, Checchin, Daniella, Daniella Checchin, Sonia Brault, Mirna Sirinyan, Elsa Kermorvant-Duchemin, Chemtob, Sylvain, Pierre Hardy, Kermorvant-Duchemin, Elsa, Balazy, Michael, Michael Balazy, Brault, Sonia   +17 more
core   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Sema3f Protects Against Subretinal Neovascularization In Vivo

, 2017
Pathological neovascularization of the outer retina is the hallmark of neovascular age-related macular degeneration (nAMD). Building on our previous observations that semaphorin 3F (Sema3f) is expressed in the outer retina and demonstrates anti ...
Samuel B. Burnim, Ludwig, Franziska, Reuer, Tristan, Yan Gong, Andreas Stahl, Ye Sun, Schlunck, Günther, Walz, Johanna M., Raffael Liegl, Daniel Böhringer, Burnim, Samuel B., Anima Bühler, Günther Schlunck, Bühler, Anima, Zhang, Peipei, Liu, Chi-Hsiu, Tristan Reuer, Smith, Lois E.H., Liegl, Raffael, Peipei Zhang, Stahl, Andreas, Sun, Ye, Hansjürgen Agostini, Chi-Hsiu Liu, Johanna M. Walz, Lange, Clemens, Steven S. Meng, Clemens Lange, Agostini, Hansjürgen, Böhringer, Daniel, Cakir, Bertan, Meng, Steven S., Gong, Yan, Lois E.H. Smith, Bertan Cakir, Franziska Ludwig   +35 more
core   +1 more source

Research progress on the use of the optical coherence tomography system for the diagnosis and treatment of central nervous system tumors

Ibrain, Volume 11, Issue 1, Page 3-18, Spring 2025.
With the advantages of high‐resolution imaging, efficient image acquisition, intraoperative real‐time detection, and radiation‐free and noninvasive characteristics, optical coherence tomography (OCT) provides accurate diagnosis and effective intraoperative guidance for the minimally invasive diagnosis and treatment of central nervous system (CNS ...
Jiuhong Li, Ziba Ayi, Gonggong Lu, Haibo Rao, Feilong Yang, Jing Li, Jiachen Sun, Junlin Lu, Xulin Hu, Si Zhang, Xuhui Hui   +10 more
wiley   +1 more source

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source