Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao +10 more
wiley +1 more source
Microglia in retinal vascular diseases: inflammatory mechanism and therapeutic target. [PDF]
Xu J +6 more
europepmc +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
Palladium-103 brachytherapy with continuous periodic intravitreal Anti-VEGF bevacizumab for ciliary body medulloepithelioma. [PDF]
Wingate SL, Finger PT.
europepmc +1 more source
Metrnl: A Novel Therapeutic Target in Atherosclerosis
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source
Enhancing Regenerative Outcomes: Histopathological Comparison of Calcium Hydroxylapatite Alone and Combined With Platelet-rich Fibrin: A 6-week Study. [PDF]
Hernández J +5 more
europepmc +1 more source
Association between periodontitis and exudative retinal detachment: A population‐based cohort study
Abstract Background To investigate whether periodontitis, a common bacterial‐induced inflammatory condition, serves as a risk factor for exudative retinal detachment (ERD), which results from fluid entering the subretinal space due to damage to the retinal pigment epithelium or leaky intraocular vessels, typically associated with inflammatory ...
Earl Fu +5 more
wiley +1 more source
Closing the Left Atrial Appendage Does Not Always Close the Story: Lessons From a Giant Left Atrial Appendage After Surgical Closure. [PDF]
Nagaoka E.
europepmc +1 more source
Biomarkers of native liver survival and portal hypertension in biliary atresia
Abstract Objective To evaluate the prognostic value of noninvasive markers Aspartate Aminotransferase to Platelet Ratio Index (APRi) and Infantile Biliary Atresia Liver Fibrosis score (iBALF), as well as the histological Ishak fibrosis score, as predictors of native liver survival (NLS) and portal hypertension (PH) in children with biliary atresia (BA)
Karyne Sumico de Lima Uyeno Jordão +2 more
wiley +1 more source

