Results 191 to 200 of about 150,746 (305)

Severe Pediatric Ocular Surface Disease: Multimodal Approach and Treatment. [PDF]

Pediatr Rep
Vilaverde L, Ribeiro BB, Parreira R, Gomes M, Menéres P, Barbosa I.   +5 more
europepmc   +1 more source

Recent Advances in Cryogel Applications for Musculoskeletal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

Gene Therapy for Corneal Diseases. [PDF]

BioTech (Basel)
Bhujel B, Eah KS, Kang SS, Chung HS, Kim JY.   +4 more
europepmc   +1 more source

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

Immunomodulatory, Antibacterial, Antioxidative and EGF‐Delivering Hydrogel Remodels Wound Microenvironment for Infected Diabetic Wound Healing

National Materials, EarlyView.
In this study, we engineered an antibacterial, antioxidative and epidermal grow factor‐encapsulated multifunctional hydrogel for the repair of chronic and refractory wounds. The hydrogel markedly promoted wound healing in rat models of diabetic foot ulcers and infected wounds by modulating wound microenvironment.
Zheng Zou, Yang Gao, Desheng Qi, Zhen Zhang, Chaoliang He, Xuesi Chen   +5 more
wiley   +1 more source

Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy. [PDF]

Optom Vis Sci
Guro M, Wang H, Phu J, Sapoznik KA, Shah H, Zhang ML, Kalloniatis M.   +6 more
europepmc   +1 more source

Clinical prognostic risk model optimization based on vascular density in neuroblastoma

Pediatric Investigation, EarlyView.
This study integrates lymphatic vessel density with the International Neuroblastoma Risk Group (INRG) risk classification to develop a more accurate clinical prognostic model for neuroblastoma, demonstrating superior discrimination, calibration, and clinical net benefit compared with the INRG risk classification alone.
Qiaoyin Liu, Jialin Cui, Dong Ren, Lei Yang, Xinyu Wang, Jiatong Xu, Yifan Liu, Cong Zhang, Haoyu Xu, Lejian He, Huanmin Wang, Haiyan Cheng, Guoshuang Feng, Xin Ni, Shengcai Wang, Yaqiong Jin   +15 more
wiley   +1 more source

Two‐year ultrasound follow‐up of patellar tendon, Achilles tendon and plantar fascia in collegiate athletes: Persistence of sonographic abnormalities and symptom development

PM&R, EarlyView.
Abstract Purpose To prospectively evaluate sonographic changes of the Achilles tendon, patellar tendon, and plantar fascia in a cohort of collegiate athletes over multiple seasons. Methods Longitudinal sonographic assessment was conducted in a cohort of National Collegiate Athletic Association Division I collegiate athletes.
William Reed Cone Le Beaumont, Derek C. Stokes, Curran Reddy, Luke A. Johnson, Kory Ford, Daniel M. Cushman   +5 more
wiley   +1 more source

Pericyte Snai1 ablation prevents pathological angiogenesis in retinopathy via extracellular matrix remodelling-mediated inhibition of endothelial cell activation. [PDF]

Exp Mol Med
Zhang Q, Tang B, Su Y, Liu P, Liang L, Yang Z, Zhang P, Tian C, Wen T, Duan Y, Jia D, Zhou Y, Dou G, Han H, Wang Y, Sun J, Yan X.   +16 more
europepmc   +1 more source