Results 121 to 130 of about 35,134 (335)

Intravitreal ranibizumab (Lucentis®) for the treatment of myopic choroidal neovascularization [PDF]

, 2018
Background: Macular choroidal neovascularization (CNV) is one of the most vision-threatening complications of myopia, which can lead to severe vision loss.
Ambresin, Aude, Konstantinidis, Lazaros, Mantel, Irmela, Pournaras, Jean-Antoine, Zografos, Leonidas   +4 more
core  

Method for Angiographically Guided Fine-Needle Diathermy in the Treatment of Corneal Neovascularization [PDF]

, 2016
Purpose: To describe a method to assess corneal neovascular (CoNV) complexes and identify feeder vessels for selective arterial fine-needle diathermy (FND). Methods: In patients with CoNV, color photography and corneal indocyanine green angiography (ICGA)
Ahmad, S, Brunner, M, Kaye, SB, Romano, V, Steger, B, Willoughby, CE   +5 more
core   +1 more source

Microglia in pathological neovascularization in the retina

, 2017
INTRODUCTION. Mononuclear phagocytes (e.g. microglia, macrophages) have been characterized as potential mediators of retinal neovascularization and degeneration. In vivo assessments of mononuclear phagocyte behavior in animals provides an important insight into disease that improves the understanding of pathological mechanisms and helps to approach new
openaire   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Mixed origin of neovascularization of human endometrial grafts in immunodeficient mouse models [PDF]

, 2009
peer reviewedBACKGROUND: In vivo mouse models have been developed to study the physiology of normal and pathologic endometrium. Although angiogenesis is known to play an important role in endometrial physiology and pathology, the origin of neovasculature
A. Beliard, Abulafia, Asahara, Becker, BRUNER-TRAN, C. Galant, Critchley, Debbage, Di Carlo, Donnez, E. Marbaix, Eggermont, F. Frankenne, Fraser, Galili, Galili, Gargett, Gordon, Grummer, Hickey, Hull, J.-M. Foidart, Jaffe, Kawashima, KRIKUN, M. Nisolle, M.-L. Alvarez Gonzalez, McCluggage, Mints, Murphy, Nap, Nisolle, Pe a, Risau, Rydberg, Saito, Smith, Story, Van Cauwenberge, Zeng   +39 more
core   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy [PDF]

, 2016
Diabetic retinopathy (DR) affects approximately one-third of diabetic patients and, if left untreated, progresses to proliferative DR (PDR) with associated vitreous hemorrhage, retinal detachment, iris neovascularization, glaucoma and irreversible ...
Bassuk, Alexander G., Grant, Maria B., Hsu, Chun Wei, Janisch, Kerstin M., Li, Yao, Mahajan, MaryAnn, Mahajan, Minit B., Nagasaki, Takayuki, Tosi, Joaquin, Tsang, Stephen H., Wert, Katherine, Yan, Yuanqing, Zhang, Lijuan   +12 more
core   +2 more sources

Thiazolidinediones Reduce Pathological Neovascularization in Ischemic Retina Via an Adiponectin-Dependent Mechanism [PDF]

, 2009
Akiko Higuchi, Koji Ohashi, Rei Shibata, Saki Sono-Romanelli, Kenneth Walsh, Noriyuki Ouchi   +5 more
openalex   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Stem Cell Therapy for Retinopathy of Prematurity [PDF]

, 2013
Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness that severely affecting the quality of life of these children. Few treatment options are available but without favorable outcomes.
Fu, ZJ, Lai, AKW, Lo, ACY
core   +1 more source