Results 131 to 140 of about 35,134 (335)

Two-year outcomes of intravitreal bevacizumab for choroidal neovascularization associated with a dome-shaped macula in pathologic myopia [PDF]

, 2016
Ji Hwan Lee, S C Lee, Seonghee Choi, Hyoung Jun Koh, Sung Soo Kim, Christopher Seungkyu Lee   +5 more
openalex   +1 more source

β-LGND2, an ERβ Selective Agonist, Inhibits Pathologic Retinal Neovascularization

Investigative Opthalmology & Visual Science, 2012
The goal of our study was to evaluate the in vitro and in vivo anti-angiogenic effects of ERβ selective agonist, β-LGND2, using human retinal microvascular endothelial cell (HRMVEC) cultures and a mouse model for oxygen-induced retinopathy (OIR).The selectivity of β-LGND2 was determined using binding and transactivation assays.
Anand, Giddabasappa, Jeetendra R, Eswaraka, Christina M, Barrett, Matthew N, Bauler, Zhongzhi, Wu, Muralimohan, Yepuru, Duane D, Miller, James T, Dalton   +7 more
openaire   +2 more sources

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Hepatocellular carcinoma may display elevated nestin expression in endothelial cells: experimental study

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Nestin, a class VI intermediate filament protein, is highly expressed in the portal mesenchyme and sinusoidal endothelium of the human fetal liver, but scarcely expressed in adult portal vessel endothelium.
Adriano Barreto Nogueira, Ariel Barreto Nogueira, Anderson Lino Costa, Fabiana Roberto Lima, Sheila Aparecida Siqueira, Manoel Jacobsen Teixeira   +5 more
doaj   +1 more source

Comparación de las tasas de progresión de la maculopatía miópica entre población caucásica y asiática [PDF]

, 2019
Describir el patrón y calcular la tasa de progresión de la Maculopatía Miópica en una serie española de pacientes con Miopía Patológica y comparar los resultados con los de una serie japonesa.
Fuente Gómez, Daniel de la
core  

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

DNA‐Inspired Multi‐Functional Double‐Cross‐Linking Self‐Healing Hydrogel Promotes the Healing of Diabetic Wounds

Advanced Science, EarlyView.
A self‐healing hydrogel crosslinked with dynamic nucleobase‐mimetic bonds delivers curcumin‐loaded exosomes. It promotes diabetic wound healing via a synergistic combination of antibacterial, anti‐inflammatory, pro‐angiogenic, and immunomodulatory mechanisms, providing a comprehensive therapeutic approach.
Pu Yang, Yue Hu, Yikun Ju, Naihsin Hsiung, Juyi Ye, Anquan Jian, Lanjie Lei, Bairong Fang   +7 more
wiley   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Influence of subretinal fluid in advanced stage retinopathy of prematurity on proangiogenic response and cell proliferation [PDF]

, 2014
Purpose The clinical phenotype of advanced stage retinopathy of prematurity (ROP, stages 4 and 5) cannot be replicated in an animal model. To dissect the molecular events that can lead up to advanced ROP, we examined subretinal fluid (SRF) and surgically
Cyr, Desireé, Hirose, Tatsuo, Lam, Godfrey, Lashkari, Kameran, Ma, Jie, Mehta, Manisha, Ng, Tat Fong, Tawansy, Khaled A., Taylor, Andrew W.   +8 more
core