Results 161 to 170 of about 35,134 (335)

Pegaptanib sodium for ocular vascular disease

Indian Journal of Ophthalmology, 2007
Pegaptanib sodium (Macugen™) is a selective RNA aptamer that inhibits vascular endothelial growth factor (VEGF) 165 , the VEGF isoform primarily responsible for pathologic ocular neovascularization and vascular permeability, while sparing the ...
Shukla Dhananjay, Namperumalsamy Perumalsamy, Goldbaum Mauro, Cunningham Jr Emmett   +3 more
doaj  

Unilateral Optic Disc Neovascularization in a Patient with Optic Disc Pit Depending on Proliferative Diabetic Retinopathy

Bezmiâlem Science
Optic disc pit is an excavation of the optic disc that usually develops congenital or rarely acquired, mostly located in the inferotemporal part of the disc. It is usually asymptomatic but sometimes might be symptomathic with maculopathy development.
Atilla ŞAHİN, Cansu EKİNCİ ASLANOĞLU, Hakan ÖZDEMİR   +2 more
doaj   +1 more source

380 Dietary Arg-Gln Dipeptide or Dha Reduces Pathological Neovascularization (NV) and Promotes Retinal Vessel Re-Growth (VR) in Mouse Model of Rop [PDF]

, 2010
Sergio Li Calzi, Lynn Shaw, N Li, Julia V. Busik, Kristin L. Morris, Josef Neu, M.B. Grant   +6 more
openalex   +1 more source

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Advanced Science, EarlyView.
A hyaluronic acid methacrylate (HAMA) hydrogel incorporating DNA tetrahedrons loaded with Asiatic acid (TDN@AA) was developed. HM‐TDN@AA promotes angiogenesis of endothelial cells (ECs), inhibits osteoclastogenesis from bone marrow–derived macrophages (BMDMs), and enhances osteogenesis of mesenchymal stem cells (MSCs) via STAT3‐mediated mitochondrial ...
Yiwen Huang, Yiming Zhang, Yisheng Feng, Qixiang Yang, Beiyuan Gao, Haiyang Xu, Cheng Huang, Kaili Lin, Yuanzhi Xu, Peiqi Zhu   +9 more
wiley   +1 more source

Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy

Advanced Science
Activation of hypoxia‐inducible factor 1α (HIF1α) contributes to blood‐retinal barrier (BRB) breakdown and pathological neovascularization responsible for vision loss in ischemic retinal diseases.
So‐Yeon Kim, Nam Gu Yoon, Jin Young Im, Ji Hye Lee, Juhee Kim, Yujin Jeon, Young Jae Choi, Jong‐Hwa Lee, Akiyoshi Uemura, Dong Ho Park, Byoung Heon Kang   +10 more
doaj   +1 more source

Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration [PDF]

Xin Wang, Liang Xu, Shiya Huang, Mingyan Wei, Yuan Xu, Xiao Dong Chen, Yuxin Miao, Rongrong Zong, Xiang Lin, Shiying Li, Zuguo Liu, Chen Qian   +11 more
openalex   +1 more source

Pemafibrate Prevents Retinal Pathological Neovascularization by Increasing FGF21 Level in a Murine Oxygen-Induced Retinopathy Model [PDF]

, 2019
Yohei Tomita, Nobuhiro Ozawa, Yukihiro Miwa, Ayako Ishida, M Ohta, Kazuo Tsubota, Toshihide Kurihara   +6 more
openalex   +1 more source

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

Inhibition of Pathological Mitochondrial Fission in Retinal Pigment Epithelium Mitigates Choroidal Neovascularization [PDF]

Hiroto Yasuda, Shinsuke Nakamura, Aimi Shirakawa, Yoshiki Kuse, Masamitsu Shimazawa   +4 more
openalex   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source