Results 261 to 270 of about 35,226 (335)

Efficacy and safety of fruquintinib combined with albumin‐bound paclitaxel as second‐line therapy for advanced gastric cancer following failure of PD‐1 inhibitor‐containing treatment (TACTIC GC‐01): A phase II single‐arm study

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Anti‐angiogenic drugs have shown promising efficacy as a second‐line treatment for advanced gastric cancer. However, it remains unclear how alterations in the tumor microenvironment following first‐line immunotherapy may impact tumor angiogenesis and influence subsequent therapeutic outcomes. This single‐arm study prospectively explored the
Xiaoting Ma   +11 more
wiley   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

open access: yesiNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi   +14 more
wiley   +1 more source

Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models. [PDF]

open access: yesSci Rep
Bradley A   +9 more
europepmc   +1 more source

Sequential ultrasound‐driven dynamic control of macrophage polarization combined with hydrogel for mechano‐chemical synergistic tissue repair

open access: yesInterdisciplinary Medicine, EarlyView.
This study presents an innovative therapeutic strategy that integrates sequential ultrasound therapy with an injectable oxidized dextran‐metformin (ODE‐Met) hydrogel to dynamically regulate macrophage polarization and promote angiogenesis for inflamed tissue repair.
Fulong Man   +12 more
wiley   +1 more source

Vat photopolymerization‐based bioprinting: Shaping next‐generation tissues with light

open access: yesInterdisciplinary Medicine, EarlyView.
Vat photopolymerization‐based bioprinting is revolutionizing biofabrication by enabling high‐precision construction of biological structures. This review systematically examines photopolymerization mechanisms and variants in printing techniques, discusses design principles and composition of bio‐inks, and highlights recent progress toward next ...
Wei Long Ng   +4 more
wiley   +1 more source

Endothelial MEMO1 Regulates Angiogenic Signaling in a Model of Retinopathy of Prematurity. [PDF]

open access: yesFASEB Bioadv
Ramshekar A   +10 more
europepmc   +1 more source

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