Results 61 to 70 of about 134,203 (255)

FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice

, 2017
Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration.
Zhongjie Fu, Samuel B. Burnim, Yan Gong, Nicholas J. Saba, Raffael Liegl, Morss, P. C., Saswata Talukdar, Liu, C. H., Gong, Y., Liegl, R., Fredrick, T. W., Hellström, Ann,, Meng, S. S., Chi-Hsiu Liu, Zhongxiao Wang, Ann Hellstrom, Steven S. Meng, Talukdar, S., Burnim, S. B., Wang, Z. X., Saba, N. J., Smith, L. E. H., Thomas W. Fredrick, Peyton C. Morss, Fu, Z. J., Lois E.H. Smith   +25 more
core   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Propranolol inhibition of beta-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy

, 2012
PURPOSE: Retinopathy of prematurity (ROP) is a leading cause of blindness in children and is, in its most severe form, characterized by uncontrolled growth of vision-threatening pathologic vessels.
Stahl, Andreas, Hellström, Ann,, Hurst, Christian G., Smith, Lois E. H., Pei, D. T., Xu, Dan, Hurst, C. G., Hatton, Colman J., Juan, Aimee M., Joyal, Jean-Sébastien, Chen, J., Xu, D., Stahl, A., Smith, L. E., Joyal, J. S., Juan, A. M., Hatton, C. J., Pei, Dorothy T., Hellström, Ann, Chen, Jing   +19 more
core   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Induction of Neovascularization by Activated Human Monocytes

, 1986
Neovascularization, the process of new blood vessel growth, is an important feature of many pathologic and physiologic processes. Monocytes were isolated from citrated blood buffy coat of healthy adult human donors on Ficoll-Hypaque gradients ...
Peter J Polverini, Alisa E Koch, S Joseph Leibovich   +2 more
core   +1 more source

Atlas‐Guided CD55‐Enriched Neutrophil Extracellular Vesicles for Complement–Macrophage Modulation in Diabetic Wounds

Advanced Science, EarlyView.
ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu   +12 more
wiley   +1 more source

The role of anti-VEGF agents in myopic choroidal neovascularization: Current standards and future outlook [PDF]

, 2016
Introduction The global prevalence of pathologic myopia is 0.9-3.1%, and visual impairment is found in 0.1-0.5% of European and 0.2-1.4% of Asian studies. Myopic choroidal neovascularization (mCNV) affects 5.2-11.3% of pathologic myopia patients and is a
Rückert, Rene, Munk, Marion, Zinkernagel, Martin, Ebneter, Andreas, Wolf, Sebastian, Rückert R, Ebneter A, Wolf S, Munk MR, Zinkernagel M   +9 more
core   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization

, 2018
Purpose: Neurofibromatosis type 1 (NF1) is the result of inherited mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin.
Stephen B. Haigh, Brian K. Stansfield, Weintraub, Neal L., Chintan Patel, Hudson, Farlyn Z., David A. Ingram, Ingram, David A., Rojas, Modesto, Fulton, David J., Stansfield, Brian K., Rebekah Tritz, Hanfang Zhang, Xu, Zhimin, Caldwell, Ruth B., Patel, Chintan, Modesto Rojas, Tritz, Rebekah, Neal L. Weintraub, Zhang, Hanfang, Bordán, Zsuzsanna, Zsuzsanna Bordán, Farlyn Z. Hudson, David J. Fulton, Zhimin Xu, Haigh, Stephen B., Ruth B. Caldwell   +25 more
core   +1 more source

Rational Surface Engineering Reduces Advanced Glycation End‐Product Adsorption and Improves Implant Integration

Advanced Science, EarlyView.
Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le, Wenhao Chen, Tengxiao Huang, Tien Thanh Nguyen, Markos Negash Alemie, Xuan Duy Do, Giles Best, Jordan Li, Jitraporn Vongsvivut, Vi‐Khanh Truong, Weiwei Li, Yunpeng Zhao, Richard Bright, Krasimir Vasilev   +13 more
wiley   +1 more source