Results 81 to 90 of about 26,345 (302)

Management of Choroidal Neovascularization Secondary to Pathological Myopia

Asia-Pacific Journal of Ophthalmology, 2014
Choroidal neovascularization (CNV) secondary to pathological myopia is an important cause of significant visual impairment in young adults. High myopia is particularly prevalent in Asian population. New scientific contributions have been made to the understanding of high myopia and myopic CNV.
Mary, Ho, David T L, Liu, Alvin L, Young, Dennis S C, Lam   +3 more
openaire   +2 more sources

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Use of ranibizumab for the treatment of subretinal neovascularization in pathologic myopia: a prospective study

Journal of Ophthalmology, 2016
Purpose: To determine the efficacy of ranibizumab as a treatment for subretinal neovascularization (SRNV) in pathologic myopia. Materials and Methods: This was an uncontrolled, prospective cohort study, involving 66 pathologic myopic eyes (65 patients)
О.M. Blavatska, T.B. Kustry, A.R. Korol
doaj   +1 more source

Metabolomic Profiling of Aqueous Humor from Pathological Myopia Patients with Choroidal Neovascularization [PDF]

, 2023
Qiaoling Wei, Zhiqiang Yu, Xianjin Zhou, Ruowen Gong, Rui Jiang, Gezhi Xu, Wei Liu   +6 more
openalex   +1 more source

Synergistic Sunlight‐Activated Photodynamic and Near‐Infrared‐Induced Mild Photothermal Therapy for Infected Wound Healing Using Functionalized Nano‐Bi2WO6 Composites

Advanced Science, EarlyView.
This work proposes a multifunctional Bi2WO6:Yb,Er@CuS@CS nanocomposite that integrates photodynamic therapy (PDT), near‐infrared‐triggered photothermal therapy (PTT), and Cu2+ release for infected wound repair. The nanocomposite demonstrates enhanced antibacterial efficacy via combined PDT, PTT, and Cu2+ release, effective immunomodulatory by mild ...
Yihao Sun, Liangrui He, Zhijun Shen, Yuxin Zhang, Yizhang Tang, Xujiang Yu, Jisi Zheng, Moran Huang, Wanwan Li, Lei Wang   +9 more
wiley   +1 more source

Microglia in pathological neovascularization in the retina

, 2017
INTRODUCTION. Mononuclear phagocytes (e.g. microglia, macrophages) have been characterized as potential mediators of retinal neovascularization and degeneration. In vivo assessments of mononuclear phagocyte behavior in animals provides an important insight into disease that improves the understanding of pathological mechanisms and helps to approach new
openaire   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

Morphologic Features of Myopic Choroidal Neovascularization in Pathologic Myopia on Swept-Source Optical Coherence Tomography [PDF]

, 2020
Jiamin Xie, Qiuying Chen, Jiayi Yu, Hao Zhou, Jiangnan He, Weijun Wang, Ying Fan, Xun Xu   +7 more
openalex   +1 more source

Multifunctional Bioactive Scaffold Facilitating BMSCs‐Driven Osteogenesis and Vascularization in Critical‐Sized Bone Defect Repair

Advanced Science, EarlyView.
A dual‐network bFGF@CB‐gel integrates: i) ChSMA scaffold (mechanical support/BMSCs delivery); ii) BC carrier (sustained bFGF release via EGFL/Itga2b and COMP/PI3K/AKT for adhesion/osteogenesis); iii) bFGF/PI3K/AKT/eNOS for angiogenesis. This rational, synergistic design addresses CSD bone regeneration challenges.
Yunze Feng, Bingzhi Chen, Yu Xu, Xin Xu, Bingtao Hu, Tongbo Li, Dingxin Zhang, Baoshuai Bai, Chen Liu, Wanlong Xu, Le Li, Wencan Zhang, Haipeng Si   +12 more
wiley   +1 more source