Results 11 to 20 of about 224,992 (367)

The immune cell landscape in kidneys of patients with lupus nephritis [PDF]

Nature Immunology, 2019
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control
A. Arazi, Deepak A. Rao, C. Berthier, A. Davidson, Yanyan Liu, P. Hoover, A. Chicoine, T. Eisenhaure, A. Jonsson, Shuqiang Li, David J. Lieb, Fan Zhang, Kamil Slowikowski, E. Browne, A. Noma, Danielle Sutherby, S. Steelman, D. Smilek, Patti Tosta, W. Apruzzese, E. Massarotti, M. Dall'Era, Meyeon Park, D. Kamen, R. Furie, F. Payan-Schober, W. Pendergraft, E. McInnis, J. Buyon, M. Petri, C. Putterman, K. Kalunian, E. Woodle, J. Lederer, David A Hildeman, C. Nusbaum, S. Raychaudhuri, M. Kretzler, J. Anolik, M. Brenner, D. Wofsy, N. Hacohen, B. Diamond   +42 more
semanticscholar   +3 more sources

In Patients with Membranous Lupus Nephritis, Exostosin-Positivity and Exostosin-Negativity Represent Two Different Phenotypes.

Journal of the American Society of Nephrology, 2021
BACKGROUND In patients with secondary (autoimmune) membranous nephropathy, two novel proteins, Exostosin 1 and Exostosin 2 (EXT1/EXT2), are potential disease antigens, biomarkers, or both.
A. Ravindran, M. Casal Moura, F. Fervenza, S. Nasr, M. Alexander, M. Fidler, Loren P. Herrera hernandez, Pingchuan Zhang, J. Grande, L. Cornell, Louann Gross, V. Negron, Grace E Jenson, B. Madden, M. C. Charlesworth, S. Sethi   +15 more
semanticscholar   +1 more source

A Patient with Henoch-Schönlein Purpura with Intussusception and intractable Nephritis [PDF]

Childhood Kidney Diseases, 2016
Henoch-Schönlein purpura (HSP) is the most common vasculitis in children, mainly affecting the small vessels of the skin, joints, gastrointestinal tract, and kidneys.
Min Kyoung Seo, Jeong Hong, Hyun Ee Yim, Ki Soo Pai   +3 more
doaj   +1 more source

Lupus nephritis: clinical presentations and outcomes in the 21st century

Rheumatology, 2020
Lupus nephritis (LN) is a frequent and severe manifestation of SLE. Along the decades, the epidemiology of LN and its clinical presentation have been changing.
M. Gasparotto, M. Gatto, V. Binda, A. Doria, G. Moroni   +4 more
semanticscholar   +1 more source

Phase II Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis

Arthritis & Rheumatology, 2020
To assess the safety, mechanism of action, and preliminary efficacy of rituximab followed by belimumab in the treatment of refractory lupus nephritis (LN).
Y. Atisha-Fregoso, S. Malkiel, Kristina M. Harris, M. Byron, L. Ding, S. Kanaparthi, William T. Barry, W. Gao, Kristin Ryker, Patti Tosta, A. Askanase, S. Boackle, W. Chatham, D. Kamen, David Karp, K. Kirou, S. Sam Lim, B. Marder, M. McMahon, Samir V. Parikh, W. Pendergraft, Amber S. Podoll, A. Saxena, D. Wofsy, B. Diamond, Dawn Smilek, C. Aranow, M. Dall'era   +27 more
semanticscholar   +1 more source

ACIDOSIS IN NEPHRITIS [PDF]

Journal of the American Medical Association, 1920
The subject of acidosis in nephritis is one of such practical importance that it deserves emphasis from a clinical standpoint. Many significant observations bearing on this general topic have accumulated during the last ten years. In the study of this question, Van Slyke's simple method 1 of determining the alkali reserve of the body with the aid of ...
Victor C. Myers, Arthur F. Chace
openaire   +2 more sources

The involvement of T regulatory lymphocytes in a cohort of lupus nephritis patients: a pilot study [PDF]

, 2015
T regulator lymphocytes (Tregs) play a key role in the maintenance of immune tolerance and in the development of autoimmune diseases. Expression of Foxp3 is specific for Tregs, and can be used for the identification of these cells.
Afeltra, Antonella, Amoroso, Antonio, Barbano, Biagio, Cianci, Rosario, Gigante, Antonietta, Liberatori, Marta, Margiotta, Domenico Paolo Emanuele, ROSSI FANELLI, Filippo, Taffon, Chiara   +8 more
core   +1 more source

Lupus nephritis management guidelines compared [PDF]

, 2015
In the past years, many (randomized) trials have been performed comparing the treatment strategies for lupus nephritis. In 2012, these data were incorporated in six different guidelines for treating lupus nephritis.
Bajema, IM, Bertsias, GK, Boumpas, DT, Gordon, C, Jayne, DR, Lightstone, L, Tesar, V, Wilhelmus, S   +7 more
core   +1 more source

Uso de micofenolato mofetil em pacientes com lúpus eritematoso sistêmico juvenil e nefrite refratária Use of mycophenolate mofetil in patients with juvenile systemic lupus erythematosus and refractory nephritis

Revista Brasileira de Reumatologia, 2004
O micofenolato mofetil (MFM) é uma droga imunossupressora utilizada no tratamento de doenças auto-imunes, incluindo o lúpus eritematoso sistêmico juvenil, particularmente nos casos de nefrite lúpica refratária à terapia com corticosteróides ...
Ricardo Maisse Suehiro, Bernadete Lourdes Liphaus, Mércia Moreira Facó, Lúcia Maria Mattei Arruda Campos, Clovis Artur Almeida Silva   +4 more
doaj   +1 more source

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance IgG antibodies are a key component of adaptive humoral immunity but can cause organ damage if they bind self-antigen, as occurs in the autoimmune disease systemic lupus erythematosus (SLE).
Chenzhi Jing, Tomas Castro-Dopico, N. Richoz, Z. Tuong, J. Ferdinand, Laurence S. C. Lok, K. Loudon, G. Banham, R. Mathews, Zaeem Cader, Susan F. Fitzpatrick, Kathleen R. Bashant, M. Kaplan, A. Kaser, R. Johnson, M. Murphy, R. Siegel, M. Clatworthy   +17 more
semanticscholar   +1 more source