Results 51 to 60 of about 4,888 (207)

Rescue of Epilepsy‐Associated Mutations of the Highly Conserved Glycine Residue 443 in the Human GABA Transporter 1

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Mutations in the human GABA transporter 1 (hGAT‐1) gene impair GABA transport, leading to developmental disorders like epilepsy and autism. These mutations often disrupt protein folding. Pharmacochaperones can rescue transporter expression and function in heterologous cell lines and in Drosophila melanogaster, thus offering potential therapeutic ...
Nikita Shah, Vasylyna Kovalchuk, Rocco Zerlotti, Kim Cole, Andre Bazzone, Harald H. Sitte, Thomas Hummel, Ameya S. Kasture, Sonja Sucic   +8 more
wiley   +1 more source

Advanced Materials for Biological Field‐Effect Transistors (Bio‐FETs) in Precision Healthcare and Biosensing

Advanced Healthcare Materials, Volume 14, Issue 13, May 16, 2025.
This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey, Manish Bhaiyya, Prakash Rewatkar, Jitendra B. Zalke, Nitin P. Narkhede, Hossam Haick   +5 more
wiley   +1 more source

About Insipidus Syndrome in Pediatric Practice

Zdorovʹe Rebenka, 2013
В статье приведены данные об этиологии, патогенезе, клинике и дифференциальной диагностике инсипидарного синдрома, а также описан случай собственного клинического наблюдения нефрогенного несахарного диабета у мальчика 17 лет.
M.S. Ostropolets, G.V. Golubytska, S.S. Pylneva   +2 more
doaj   +1 more source

Editorial Introduction: Advancing Pediatric Endocrinology Through Multidimensional Insights

Clinical Endocrinology, Volume 103, Issue 4, Page 427-428, October 2025.
Tony Huynh
wiley   +1 more source

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, Volume 12, Issue 19, May 22, 2025.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Contextualizing guidelines for the health system of Cyprus: Experiences and lessons learnt

Clinical and Public Health Guidelines, Volume 2, Issue 2, April 2025.
Abstract Background Cyprus is undergoing a major health reform with the recent establishment of the General Healthcare System (GHS). The GHS offers equal healthcare access through one primary insurer (Health Insurance Organization [HIO]) and benefits from a wide collaborative network of public and private healthcare providers.
Panayiotis Kouis, Hugh McGuire, Monika Kyriacou, Anneza Yiallourou, Anastasis Sioftanos, Ourania Kolokotroni, Haris Achilleos, Craig Grime, Pilar Pinilla‐Dominguez, Giorgos Giallouros, Christina Englezou, Contextualization group, George Athanasiou, Elias Avraam, Mary Avraamidou, Anastasios Bagourdis, Charis Charilaou, Stelios Christodoulou, Natasa Christofides, Theodoros Christophides, Vasilis Constantinidis, Dimitris Dimitriou, Stella Eleftheriadou, Christina Flourou, Savvas Frangos, Kyriakos Frantzeskou, Costas Hoplaros, Kyriakos Ioannou, Nikolaos Kadoglou, Chara Kalogirou, Vasileios Karathanos, Andreas Kostis, Andreas Kousios, Ekaterini Lambrinou, Emily Mavrokordatou, Michael Michael, Nicos Mitsides, Chrystalleni Mylonas, Georgia Orphanou, Elias Papasavvas, Doros Polydorou, Stavros Stavrou, Elena Theofanous, Despo Theodorou, Giannis Thrasyvoulou, Chryssa Tziakouri‐Shakalli, Theodora Vassiliou, Alexis Vrachimis, Panayiotis K. Yiallouros, Georgios K. Nikolopoulos   +49 more
wiley   +1 more source

Kidney function decline improves after lithium discontinuation

Journal of Internal Medicine, Volume 297, Issue 3, Page 289-299, March 2025.
Abstract Background Long‐term lithium treatment decreases kidney function. However, it remains unclear whether stopping lithium improves kidney function. Objectives To study kidney function in patients who stopped and subsequently restarted lithium treatment. Methods Mirror‐image design using data from the LiSIE retrospective cohort study.
Filip Fransson, Ursula Werneke, Louise Öhlund, P. Andreas Jonsson, Michael Ott   +4 more
wiley   +1 more source

Primary Amenorrhea in a 15‐Year‐Old Girl Leading to the Diagnosis of Bardet‐Biedl Syndrome: A Case Report

Clinical Case Reports, Volume 13, Issue 1, January 2025.
ABSTRACT This case report highlights the clinical complexity of Bardet‐Biedl syndrome, a rare autosomal recessive disorder, emphasizing reproductive anomalies to aid in diagnosis and management. It underscores the importance of thorough assessment and advocates for genetic testing to optimize care, despite current financial, and laboratory constraints.
Azka Noor, Digbijay Kunwar, Zahra Tasneem, Saad Ameer Ishaq   +3 more
wiley   +1 more source

Serum Antidiuretic Hormone Level in Nocturnal Enuretic School Children in a Tertiary Care Hospital in Bangladesh: A Cross‐Sectional Study

Health Science Reports, Volume 8, Issue 1, January 2025.
ABSTRACT Background and Aims Primary nocturnal enuresis (PNE) is a common pediatric condition characterized by involuntary nighttime bed wetting. Primary monosymptomatic nocturnal enuresis (PMNE) is associated with altered antidiuretic hormone (ADH) secretion and lacks lower urinary tract symptoms.
Jannatul Fardous, Anjuman Ara, Md. Iqbal Hossain, Asma Labony, Tanjila Afrin, Rezwana Ashraf, Reaz Uddin, Habiba Jesmin, Md. Kabir Alam, Mohammad Ashraful Amin, Anwar Hossain Khan, Zahid Hasan Khan   +11 more
wiley   +1 more source

Orally administered prednisolone decreases plasma arginine vasopressin and serum copeptin concentrations in healthy dogs

Journal of Veterinary Internal Medicine, Volume 39, Issue 1, January/February 2025.
Abstract Background The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood. Objective Investigate plasma AVP (pAVP) and serum CoP (sCoP) concentrations in healthy dogs before, during, and after abrupt discontinuation of a long‐term course of orally administered prednisolone.
Mathieu Victor Paulin, Dorsa Mehrabanpour, Suraj Unniappan, Elisabeth C. R. Snead   +3 more
wiley   +1 more source