Results 41 to 50 of about 39,341 (170)

Genetic causes of hypercalciuric nephrolithiasis. [PDF]

, 2008
Renal stone disease (nephrolithiasis) affects 3-5% of the population and is often associated with hypercalciuria. Hypercalciuric nephrolithiasis is a familial disorder in over 35% of patients and may occur as a monogenic disorder that is more likely to ...
Michael J. Stechman, Rajesh V. Thakker, Thakker, Rajesh, Loh, NY, Stechman, MJ, Nellie Y. Loh, Thakker, RV   +6 more
core   +1 more source

Additive Association of <italic>ABCG2</italic> rs4148155 and <italic>SLC22A12</italic> rs75786299 Polymorphisms with Hyperuricemia, Gout, and Nephrolithiasis: A Hospital-Based, Case-Control Study

Kidney Diseases
Introduction: This study aimed to investigate the interaction between the ABCG2 rs4148155 and SLC22A12 rs75786299 variants and their association with incident gout and nephrolithiasis in the Taiwanese population to better understand the ...
Ching-Tsai Lin, I-Chieh Chen, Yen-Ju Chen, Ying-Cheng Lin, Jui-Chun Chang, Tsai-Jung Wang, Wen-Nan Huang, Yi-Hsing Chen, Chia-Yi Wei, Ching-Heng Lin, Yi-Ming Chen   +10 more
doaj   +1 more source

A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. [PDF]

PLoS Genetics, 2012
Nephrolithiasis is a common nephrologic disorder with complex etiology. To identify the genetic factor(s) for nephrolithiasis, we conducted a three-stage genome-wide association study (GWAS) using a total of 5,892 nephrolithiasis cases and 17,809 ...
Yuji Urabe, Chizu Tanikawa, Atsushi Takahashi, Yukinori Okada, Takashi Morizono, Tatsuhiko Tsunoda, Naoyuki Kamatani, Kenjiro Kohri, Kazuaki Chayama, Michiaki Kubo, Yusuke Nakamura, Koichi Matsuda   +11 more
doaj   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Education of patient with nephrolithiasis [PDF]

, 2018
Bakalářská práce se zaměřuje na edukaci pacienta s nefrolitiázou.Teoretická část práce obsahuje anatomii a fyziologii vývodných cest močových, charakteristiku nefrolitiázy včetně její epidemiologie, klinických příznaků, diagnostických postupů, terapie a ...
Čížková, Hana
core   +1 more source

Association of Urinary pH With Overall Survival in Patients With Stage IV Cancer: A Single‐Center Retrospective Cohort Study

Cancer Nexus, EarlyView.
ABSTRACT Objective This single‐center retrospective cohort study evaluated whether, among patients with stage IV cancer who participated in a pragmatic “alkalization therapy”—defined as a low potential renal acid load diet plus oral sodium bicarbonate and/or potassium/sodium citrate—urinary pH was associated with long‐term survival.
Shion Kachi, Kazuyuki Suzuki, Reo Hamaguchi, Ryoko Narui, Hiromasa Morikawa, Hiromi Wada   +5 more
wiley   +1 more source

Prevalence of nephrolithiasis in patients with ileal bladder substitutes

, 2008
OBJECTIVES: To assess the effect of ileal bladder substitutes with preservation of the ileocecal valve and distal 25 cm of ileum on nephrolithiasis. METHODS: We reviewed a consecutive series of 518 patients (44 women and 474 men) with ileal orthotopic ...
Hernandez, Adrian V, Reinhardt, Karsten, Müller, Roger M, Zehnder, Pascal, Dhar, Nivedita Bhatta, Studer, Urs E, Giannarini, Gianluca   +6 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Multiomics Mendelian randomization integrating pQTL, eQTL and mQTL data revealed BTN3A2 as a potential drug target for nephrolithiasis

Scientific Reports
Nephrolithiasis has a high recurrence rate and imposes a heavy burden on patients and society. Therefore, there is an urgent need to explore new effective targets for nephrolithiasis prevention and treatment.
Shanshan Sun, Yutao Wang, Qingzhuo Dong, Jianbin Bi, Yang Fu   +4 more
doaj   +1 more source

Correlation of Stone Size and Urine Leukocytes in Nephrolithiasis Patients at Ulin General Hospital Banjarmasin

Berkala Kedokteran, 2021
: Nephrolithiasis (Kidney Stone) is a condition where there is stone in the kidney that are formed due to disturbance of the balance between solubility and deposition of salt in urine.
Noorsyifa Safitri Tahir, Eka Yudha Rahman, Dewi Indah Noviana Pratiwi, Heru Prasetya, Siti Kaidah   +4 more
doaj   +1 more source