Results 91 to 100 of about 323,772 (303)

Interpretable Machine Learning Analysis of Inflammatory Biomarkers for Predicting Arteriovenous Fistula Stenosis in Hemodialysis Patients: A Retrospective Cohort Study

International Journal of General Medicine
Xia Wang,* Peng Shu,* Zhuping Wen, Qian Xie, Fang Xu Department of Nephrology, The Central Hospital of Wuhan, Wuhan, Hubei,People’s Republic of China*These authors contributed equally to this workCorrespondence: Fang Xu, Email ...
Wang X, Shu P, Wen Z, Xie Q, Xu F
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Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Gestational Diabetic Ketoacidosis Complicated by a Probable Postpartum Functional Neurological Disorder Following Severe Preeclampsia and Intrauterine Fetal Demise: A Case Report

International Medical Case Reports Journal
Migisha Kazeneza Patrick,1 Célestin Kaputu-Kalala-Malu Snr,2 Antoine Osongo Onanga W.,1 Baguma Mahemu Paulin,3 Koko Mihigo Francine Snr,1 Zanga Kitutu Jean,4 Baanitse Munihire Jeannot51Obstetrics and Gynecology Department, Sapientia Catholic University ...
Patrick MK, Kaputu-Kalala-Malu Snr C, Onanga W. AO, Paulin BM, Francine Snr KM, Jean ZK, Jeannot BM   +6 more
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Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

ADNP‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman, Ana Kolevzon, Paige Siper, Tess Levy, Jeffrey M. Saland, Yitzchak Frank, Robert Rapaport, Kayla Kupietzky, William E. Bennett Jr, Bruce Gelb, Sandra Bedrosian Sermone, Alexander Kolevzon   +11 more
wiley   +1 more source

Expanding Community Nephrology Exposure in Nephrology Training Programs

Kidney News Welcomes Editorial Fellows In July, three nephrology fellows were selected to join the
Susan Jeevana Thanabalasingam
core   +1 more source

A Novel Constitutional TUBB Variant Associated With Familial Malformations of Cortical Development

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Most pathogenic tubulin variants arise de novo in sporadic patients, causing severe brain malformations and significant neurodevelopmental impairment. The resulting reproductive disadvantage typically prevents these mutations from being transmitted to offspring.
Elena Cellini, Davide Mei, Mara Cavallin, Simona Fiori, Luciana Tramacere, Maria Elena Melica, Giulia Antonelli, Simona Virdò, Elena Parrini, Renzo Guerrini   +9 more
wiley   +1 more source

Nursing Diagnoses and Interventions in the Field of Action for Patients Undergoing Renal Replacement Therapy: A Scoping Review

Nursing Open
Aim To identify the primary nursing diagnoses and interventions related to patients with chronic kidney disease undergoing renal replacement therapy, organised according to Marjory Gordon's functional health patterns through a scoping review.
Miguel Angel Cuevas‐Budhart, José Ramón Paniagua Sierra, Renata Cedillo‐Flores, Sonsoles Hernandez‐Iglesias, Almudena Crespo Cañizarez, Maria Alina Renghea, José Antonio Herrero Calvo, Vicente Beneit Montesinos, Mercedes Gómez Del Pulgar G   +8 more
doaj   +1 more source

Pharmacokinetics and Safety with Bioequivalence of Isosorbide Mononitrate Sustained-Release Tablets in Chinese Healthy Volunteers: Bioequivalence Study

Drug Design, Development and Therapy
Binbin Wu,1 Wei Wang,2 Qikun Zhang,3 Guigui Yu,1 Jingjing Lin,1 Ting Zhang,1 Luxi Ye,1 Keli Wang,4 Wanggang Zhang,5,* Xinyi Wu5,* 1Department of Nephrology, Zhejiang Hospital, Hangzhou, 310030, People’s Republic of China; 2Department of ...
Wu B, Wang W, Zhang Q, Yu G, Lin J, Zhang T, Ye L, Wang K, Zhang W, Wu X   +9 more
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