Results 71 to 80 of about 323,772 (303)

Lysozyme nephropathy in chronic myelomonocytic leukemia

Clinical Case Reports, 2019
Lysozyme nephropathy is a frequently unrecognized cause of renal disease in chronic myelomonocytic leukemia and may serve as a novel indication for treatment in this patient population.
Ami B. Patel, Rodney R. Miles, Michael W. Deininger   +2 more
doaj   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

A Call for an Ethics and Governance Action Plan to Harness the Power of Artificial Intelligence and Digitalization in Nephrology

, 2021
Digitalization in nephrology has progressed in a manner that is disparate and siloed, even though learning (under a broader Learning Health System initiative) has been manifested in all the main areas of clinical application.
Ho, WLC, Caals, K
core   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Point-of-Care Ultrasound in Nephrology: A Message from Young Nephrologists

Point-of-care ultrasound (POCUS) is emerging as a valuable adjunct tool to medical history and physical examination, enhancing the diagnosis and management of diseases.
Şafak Mirioğlu, Kumru, Gizem, Hugo Diniz, Helvaci, Özant, Dinçer, Mevlüt Tamer, Berke, Ilay, Yelda Deligöz Bildacı, Mevlüt Tamer Dinçer, Mirioğlu , Şafak, Deligöz Bildaci, Yelda, Diniz, Hugo, İlay Berke, Özant Helvacı, Gizem Kumru   +13 more
core   +1 more source

Malnutrition and Muscle Loss Mediate the Association Between NT-proBNP and Mortality in Hospitalized Older Adults

Clinical Interventions in Aging
Jun Tao,1,2 Xiaoyan Zhang,2 Niansong Wang,1 Dongsheng Cheng1 1Department of Nephrology, Shanghai Sixth People’s Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Geriatrics ...
Tao J, Zhang X, Wang N, Cheng D
doaj  

Next Generation Sequencing: A Tool for This Generation of Nephrologists [PDF]

European Medical Journal, 2016
The emergence of next generation sequencing (NGS) techniques has made the sequencing of whole genomes, transcriptomes, and epigenomes faster and more readily available than previous methods such as Sanger sequencing, which was developed in the 1970s.
Lea Landolt, Philipp Strauss, Hans-Peter Marti, Øystein Eikrem   +3 more
doaj  

СТРАНИЦЫ ИСТОРИИ НЕФРОЛОГИИ ДОНА ПЕРВОЙ ПОЛОВИНЫ XX ВЕКА

Архивъ внутренней медицины, 2013
In this article you can find main stages of development of nephrology in first half of XX century in Rostov aria. Information about professors, which work was concentrated on nephrology pathology provided in article. Among them: Z.V.
М. М. Батюшин, В. П. Терентьев   +1 more
doaj   +1 more source

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source