Results 101 to 110 of about 328,619 (354)

Further investigation of confirmed urinary tract infection (UTI) in children under five years: a systematic review. [PDF]

, 2005
Background: Further investigation of confirmed UTI in children aims to prevent renal scarring and future complications. Methods: We conducted a systematic review to determine the most effective approach to the further investigation of confirmed urinary ...
A Biggi, A Fretzayas, A Gervaix, A Haberlik, A Hitzel, A Hitzel, A Piepsz, AL Valentini, AR Bergius, B Boudailliez, B Jakobsson, B Mucci, BA Jantausch, BP Barry, C Antachopoulos, C De Sadeleer, C Prat, C Radmayr, D Baronciani, D Benador, D Landau, D Landau, D Morin, D Siamplis, DJ Roebuck, E Stokland, E Stokland, E Stokland, ED Evans, F Castello Girona, F Guermazi, FE Pickworth, G Alzen, G Capa Kaya, G Krzemien, G Piaggio, G Zamir, GA McLorie, GN Sfakianakis, GW LeQuesne, HC Scherz, HJ Mentzel, I Gordon, I Gordon, Ian S Watt, IG Verber, J Larcombe, J Stock, J Winberg, JG Lijmer, JL Fleiss, Jos Kleijnen, JR MacKenzie, Julie Cooper, K Everaert, K Mage, K Schneider, L Von Rohden, LE Moses, M el Hajjar, M Hellstrom, M Ilyas, M Nakamura, M Salih, M Uhl, M Wennerstrom, M Wennerstrom, Marie E Westwood, MD Muro, MP Andrich, MP Lavocat, MR Ditchfield, MV Merrick, N Buyan, N Le Saux, OJ Muensterer, P Whiting, Penny F Whiting, PJ Hedman, PT Dick, PT Dick, R DerSimonian, R Oostenbrink, RF Galbraith, RL McEwing, RM Kessler, S Bykov, S Jequier, S Mahant, SH Sacks, SJ Vernon, SM Tan, T Berrocal, T Berrocal Frutos, T Dura Trave, U Alon, V Smolkin, V Sreenarasimhaiah, WH Foresman, Working Group of the Research Unit of the Royal College of Physicians, ZE Bircan   +100 more
core   +3 more sources

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

Arthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Linear Mixed-Effects Models for Non-Gaussian Repeated Measurement Data [PDF]

arXiv, 2018
We consider the analysis of continuous repeated measurement outcomes that are collected through time, also known as longitudinal data. A standard framework for analysing data of this kind is a linear Gaussian mixed-effects model within which the outcome variable can be decomposed into fixed-effects, time-invariant and time-varying random-effects, and ...
arxiv  

EasierPath: An Open-source Tool for Human-in-the-loop Deep Learning of Renal Pathology [PDF]

arXiv, 2020
Considerable morphological phenotyping studies in nephrology have emerged in the past few years, aiming to discover hidden regularities between clinical and imaging phenotypes. Such studies have been largely enabled by deep learning based image analysis to extract sparsely located targeting objects (e.g., glomeruli) on high-resolution whole slide ...
arxiv  

Biological Pathways and Potential Targets for Prevention and Therapy of Chronic Allograft Nephropathy [PDF]

, 2014
Renal transplantation (RT) is the best option for patients with end-stage renal disease, but the half-life is limited to a decade due to progressive deterioration of renal function and transplant failure from chronic allograft nephropathy (CAN), which is
Haylor, John, Shrestha, Badri Man
core   +3 more sources

Podcasts in health education—Insights from a scoping review and survey

Anatomical Sciences Education, EarlyView.
Abstract Podcasts have rapidly emerged as a powerful tool for health communication, especially since the COVID‐19 pandemic. While evidence shows that podcasts can enhance student knowledge, confidence, and flexibility in learning, their educational impact is primarily studied within formal academic contexts.
Matthew J. Barton, Mari Okada, Michael Todorovic   +2 more
wiley   +1 more source

Interactivity and Transparency in Medical Risk Assessment with Supersparse Linear Integer Models [PDF]

arXiv, 2019
Scoring systems are linear classification models that only require users to add or subtract a few small numbers in order to make a prediction. They are used for example by clinicians to assess the risk of medical conditions. This work focuses on our approach to implement an intuitive user interface to allow a clinician to generate such scoring systems ...
arxiv  

Indirect Measurement of Hepatic Drug Clearance by Fitting Dynamical Models [PDF]

arXiv, 2020
We present an indirect signal processing-based measurement method for biological quantities in humans that cannot be directly measured. We develop the method by focusing on estimating hepatic enzyme and drug transporter activity through breath-biopsy samples clinically obtained via the erythromycin breath test (EBT): a small dose of radio-labeled drug ...
arxiv  

Changes in renal WT-1 expression preceding hypertension development [PDF]

, 2016
Background: Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information.
Abud, María Angélica, Calvo, Juan Pablo, Casarotto, Mariana, Cuello Carrión, Fernando Darío, Ferder, León, Fornes, Miguel Walter, García, Isabel Mercedes, Manucha, Walter Ariel Fernando, Mazzei, Luciana Jorgelina   +8 more
core   +2 more sources

Effect of hydration schedules on dose‐limiting toxicity in patients with head and neck squamous cell carcinoma treated with cisplatin

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to determine if head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin chemoradiotherapy and short hydration (SH) experience less dose‐limiting toxicity (DLT) and receive more cisplatin than those with medium hydration (MH) or long hydration (LH).
Anouk W. M. A. Schaeffers, Cassimy B. van Neerven, Dorieke van Balen, Mirjam Crul, Marije Slingerland, Saskia A. C. Luelmo, Jan Paul de Boer, Jens Voortman, Arjan D. van Zuilen, Remco de Bree, Lot A. Devriese   +10 more
wiley   +1 more source